This paper aims to develop specific strategies for reforming the Agricultural Research Council of Nigeria (ARCN) for achieving greater efficiency, effectiveness, impact, and sustainability through its constituent institutions. Based on a two-year consultative and interactive process of internal discussion, external learning, and analysis of various restructuring options, this paper proposes specific interventions for promoting results-based approaches to priority setting, resource mobilization and allocation, effective implementation of research programs, enhanced and timely delivery of results, mon-itoring and evaluation, impact assessment, and improved networking among domestic and international partners. The paper recommends a phased approach to ARCN reforms, beginning with organizational transformation and capacity strengthening at all levels. In addition, issues, challenges, and opportunities for sustainable funding, integration of re-search, extension, education, and the regulatory mandates of ARCN are discussed. Finally, an implementation plan for restructuring ARCN is presented.