Mutagenicity
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| Author | : Ashutosh Kumar |
| Publisher | : Academic Press |
| Total Pages | : 352 |
| Release | : 2017-09-26 |
| Genre | : Science |
| ISBN | : 0128092602 |
Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation. - Presents an up-to-date and in-depth review of the current state of mutagenesis research - Draws upon the combined experience and expertise of an international group of highly respected editors and chapter authors - Provides an introduction to the concept of mutagenesis with particular consideration given to novel chemicals and materials
| Author | : B.J. Kilbey |
| Publisher | : Elsevier |
| Total Pages | : 876 |
| Release | : 2012-12-02 |
| Genre | : Medical |
| ISBN | : 0444600981 |
The compilation of this book was prompted by the necessity of a bench volume which could provide the necessary background information on materials, experimental design, pitfalls and dificulties, in order to perform a particular test in an acceptable way with a minimal need for additional expert help. This Second Edition updates this information, providing: - a comprehensive bench guide - methods known to be reliable - a broad spectrum of approaches - tips to avoid pitfalls when using unfamiliar techniques - data from population records - safety aspects of mutagens and carcinogens - basic statistical concepts for experiment design This `on the bench' methodological text provides the necessary information for most of the common assays for genetic damage in use. The book includes methods which have been sufficiently used and tested to make their use reliable, but also presents methods which are not widely used at present, but which might prove most useful in screening for mutagenic effects.
| Author | : Samuel S. Epstein |
| Publisher | : MIT Press (MA) |
| Total Pages | : 248 |
| Release | : 1971 |
| Genre | : Chemical mutagenesis |
| ISBN | : |
This is the first book to present recently developed mammalian methodologies for evaluating mutagenic hazards of chemicals such as pesticides.
| Author | : National Research Council |
| Publisher | : Legare Street Press |
| Total Pages | : 0 |
| Release | : 2022-10-27 |
| Genre | : History |
| ISBN | : 9781015691629 |
This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
| Author | : Ernest H.Y. Chu |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 852 |
| Release | : 2012-12-06 |
| Genre | : Science |
| ISBN | : 1461323991 |
During the early 1930s, when I was a graduate student and later a post-doctoral researcher at the National Research Council for the University of Wisconsin at Madison, we had the opportunity to get acquainted with many graduate students from China who were sent to the University for training in modern basic sciences as well as social sciences. The University of Wisconsin continues to graduate a large number of Chinese students. Economic conditions in the 1930s were very precarious for the United States and other parts of the world. Many of us students grew closer together because we were living on similarly tight budgets. As a matter of fact, we subleased a part of our apartment in Madison to some Chinese graduate students. This was a very nice opportunity for us to learn about the scientific and cultural back ground of our Chinese friends. Many of them came from the interior of China and had had very little opportunity to become acquainted with people from a western culture. Living with these students was a very pleasant and educational experience which gave us a good pic ture of the cultural life and educational system of China at that time--an intimate picture that one normally would not see without travelling in that country.
| Author | : OECD |
| Publisher | : OECD Publishing |
| Total Pages | : 12 |
| Release | : 1997-07-21 |
| Genre | : |
| ISBN | : 9264071245 |
The bacterial reverse mutation test uses amino-acid requiring at least five strains of Salmonella typhimurium and Escherichia coli to detect point mutations by base substitutions or frameshifts. The principle of this bacterial reverse mutation test ...
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 791 |
| Release | : 2012-12-02 |
| Genre | : Medical |
| ISBN | : 0323139558 |
Handbook of Hazardous Materials is a one-volume compendium of hazardous materials that discusses the toxic effects of these materials on human health and the global environment. It provides comprehensive coverage of individual toxic elements, covers hazardous material groups, and includes more general articles such as evaluation and testing of carcinogens, transport of pollutants, and inhalation toxicology. The fully referenced articles are presented in alphabetical order. The book features a subject index as well as numerous cross-references.Individual articles are preceded by a topical outline and discuss the origin, prevalence, mechanisms of toxicity and damaging effects of each hazardous material.Comprehensive coverage of individual toxic elements, includingAsbestosAlarLeadMercuryCoverage of hazardous material groups, such asPesticidesFood additivesNitrogen compoundsMore general articles, such asEvaluation and testing of carcinogensTransport of pollutantsInhalation toxicology
| Author | : Ludwig Hothorn |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 158 |
| Release | : 2013-03-08 |
| Genre | : Medical |
| ISBN | : 364248736X |
This book contains selected papers from a workshop on modern statistical methods in toxicology held during the EUROTOX '90 conference in Leipzig. The papers deal with the biostatistical evaluation of the commonly used toxicological assays, i.e. mutagenicity, long-term carcinogenicity, embryotoxicity and chronic toxicity assays. The biological background is considered in detail, and most of the related statistical approaches described. In five overview papers, the present state of the art of the related topics is given, while in several contributed papers new approaches are discussed. The most important features are: - A new view on the per-litter analysis problem in em- bryotoxicity assays. - A highly sophisticated treatment of the so-called muta-tox problem in mutagenicity assays. - A detailed discussion of the multiplicity problem based on the closed testing procedure. This volume provides readers with an overview of modern biostatistical methods for several toxicological assays and is in part intended for direct, practical use.
| Author | : S. Venitt |
| Publisher | : |
| Total Pages | : 378 |
| Release | : 1984 |
| Genre | : Language Arts & Disciplines |
| ISBN | : |
LABORATORY MANUAL. GENETIC TOXICOLOGY. BACTERIA. YEAST. FRUIT FLY. CULTURED MAMMALIAN CELLS. CYTOGENETIC TESTING. RODENTS. DOMINANT LETHAL TEST.
| Author | : OECD |
| Publisher | : OECD Publishing |
| Total Pages | : 16 |
| Release | : 2011-07-28 |
| Genre | : |
| ISBN | : 9264122818 |
This Test Guideline describes an in vivo assay that detects chemicals that may induce gene mutations. In this assay, transgenic rats or mice that contain multiple copies of chromosomally integrated plasmid or phage shuttle vectors are used. The ...
