This dissertation is devoted to developing multiple access interference (MAI) reduction techniques for multi-carrier multi-user wireless communication networks. In multi-carrier code division multiple access (MC-CDMA) systems, a full multipath diversity can be achieved by transmitting one symbol over multiple orthogonal subcarriers by means of spreading codes. However, in frequency selective fading channels, orthogonality among users can be destroyed leading to MAI. MAI represents the main obstacle to support large number of users in multi-user wireless systems. Consequently, MAI reduction becomes a main challenge when designing multi-carrier multi-user wireless networks. In this dissertation, first, we study MC-CDMA systems with different existing MAI reduction techniques. The performance of the studied systems can be further improved by using a fractionally spaced receivers instead of using symbol spaced receivers. A fractionally spaced receiver is obtained by oversampling received signals in a time domain. Second, a novel circular-shift division multiple access (CSDMA) scheme for multi-carrier multi-user wireless systems is developed. In CSDMA, each symbol is first spread onto multiple orthogonal subcarriers in the frequency domain through repetition codes. The obtained frequency-domain signals are then converted to a time-domain representation. The time-domain signals of different users are then circularly shifted by different numbers of locations. The time-domain circular shifting enables the receiver to extract signals from different users with zero or a small amount of MAI. Our results show that the CSDMA scheme can achieve a full multipath diversity with a performance outperforms that of orthogonal frequency division multiple access (OFDMA). Moreover, multipath diversity of CSDMA can be further improved by employing the time-domain oversampling. Performance fluctuations due to a timing offset between transmitter and receiver clocks in MC-CDMA and CSDMA systems can be removed by employing the time-domain oversampling. Third, we study the theoretical error performance of high mobility single-user wireless communication system with doubly selective (time-varying and frequency-selective) fading channel under impacts of imperfect channel state information (CSI). Throughout this dissertation, intensive computer simulations are performed under various system configurations to investigate the obtained theoretical results, excellent agreements between simulation and theoretical results were observed in this dissertation.