Monitoring And Counteracting Functional Deterioration In Parkinsons Disease A Multilevel Integrative Approach In A Primate Model System
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Author | : |
Publisher | : |
Total Pages | : 21 |
Release | : 2006 |
Genre | : |
ISBN | : |
It is still largely unknown what the general course is in the progression of Parkinson's disease (PD). Presumably more than one factor is responsible. There is evidence suggesting that metabolic compromise, excitotoxicity and oxidative stress are involved in the neurodegenerative process causing PD. To investigate the connection of excitotoxicity and oxidative stress with metabolic compromise in the development of the disease, anti-excitotoxic treatment with riluzole and anti-oxidant treatment with EGCG will be compared to untreated controls and to a standard treatment with L-DOPA in a MPTP induced Parkinson model. We hypothesize that critical changes indicating the nature of the gradual patho-physiological changes leading to PD will be revealed if anti-oxidants or anti-excitatory treatments are given in a situation where the brain is susceptible to develop PD. The comparison, of the results on the different levels of research, between the neuroprotective regimes and the symptom control drug L-DOPA will give insight in the relative role of the different markers for neuroprotection and behavioral output. In particular relatively new technologies such as differential proteomics and sleep research will yield novel insights. In this report period new test methods were developed, the use of brain imaging or neurophysiology was validated and the dose range finding of the test compounds was performed. The highest sign-free dose will be used in the neuroprotective experiments.
Author | : Leonard A. Rosenblum |
Publisher | : Elsevier |
Total Pages | : 464 |
Release | : 2013-11-06 |
Genre | : Nature |
ISBN | : 1483275973 |
The Squirrel Monkey is devoted to the common South American squirrel monkey, Saimiri sciureus. In light of the growing number of squirrel monkeys being established each year in many laboratories, there appeared the need to pool existing knowledge in concise form. The present volume, the first of its kind on any single primate, attempts to meet this need. The topics that have been selected cover thoroughly areas of research in which Saimiri has been utilized. This material ranges widely from taxonomy and behavioral studies through husbandry and clinical management of the species, to investigations in aerospace medicine and in a number of basic biological sciences. Since the problems encountered in the squirrel monkey, though sometimes taking a particular form, are not unique in principle, the authors have attempted to provide an appropriate phylogenetic context for their material. It is hoped as a result that this compendium may serve as a valuable source of information during various phases of work on other subjects of primatological and comparative biological investigation as well.
Author | : Institute of Medicine |
Publisher | : National Academies Press |
Total Pages | : 180 |
Release | : 1991-02-01 |
Genre | : Computers |
ISBN | : 0309044979 |
Significant advances in brain research have been made, but investigators who face the resulting explosion of data need new methods to integrate the pieces of the "brain puzzle." Based on the expertise of more than 100 neuroscientists and computer specialists, this new volume examines how computer technology can meet that need. Featuring outstanding color photography, the book presents an overview of the complexity of brain research, which covers the spectrum from human behavior to genetic mechanisms. Advances in vision, substance abuse, pain, and schizophrenia are highlighted. The committee explores the potential benefits of computer graphics, database systems, and communications networks in neuroscience and reviews the available technology. Recommendations center on a proposed Brain Mapping Initiative, with an agenda for implementation and a look at issues such as privacy and accessibility.
Author | : Intergovernmental Panel on Climate Change (IPCC) |
Publisher | : Cambridge University Press |
Total Pages | : 755 |
Release | : 2022-04-30 |
Genre | : Science |
ISBN | : 9781009157971 |
The Intergovernmental Panel on Climate Change (IPCC) is the leading international body for assessing the science related to climate change. It provides policymakers with regular assessments of the scientific basis of human-induced climate change, its impacts and future risks, and options for adaptation and mitigation. This IPCC Special Report on the Ocean and Cryosphere in a Changing Climate is the most comprehensive and up-to-date assessment of the observed and projected changes to the ocean and cryosphere and their associated impacts and risks, with a focus on resilience, risk management response options, and adaptation measures, considering both their potential and limitations. It brings together knowledge on physical and biogeochemical changes, the interplay with ecosystem changes, and the implications for human communities. It serves policymakers, decision makers, stakeholders, and all interested parties with unbiased, up-to-date, policy-relevant information. This title is also available as Open Access on Cambridge Core.
Author | : Jancy C. McPhee |
Publisher | : U. S. National Aeronautics & Space Administration |
Total Pages | : 396 |
Release | : 2009 |
Genre | : Biography & Autobiography |
ISBN | : |
Author | : Nancy Y. Ip |
Publisher | : Springer Science & Business Media |
Total Pages | : 326 |
Release | : 2009-02-28 |
Genre | : Medical |
ISBN | : 0387788875 |
Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during both developmental stages and in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may serve as therapeutic treatment for a number of neurodegenerative diseases.
Author | : Allison B. Kaufman |
Publisher | : Cambridge University Press |
Total Pages | : 1032 |
Release | : 2021-07-22 |
Genre | : Psychology |
ISBN | : 110856125X |
This handbook lays out the science behind how animals think, remember, create, calculate, and remember. It provides concise overviews on major areas of study such as animal communication and language, memory and recall, social cognition, social learning and teaching, numerical and quantitative abilities, as well as innovation and problem solving. The chapters also explore more nuanced topics in greater detail, showing how the research was conducted and how it can be used for further study. The authors range from academics working in renowned university departments to those from research institutions and practitioners in zoos. The volume encompasses a wide variety of species, ensuring the breadth of the field is explored.
Author | : |
Publisher | : |
Total Pages | : 338 |
Release | : 2000 |
Genre | : Health promotion |
ISBN | : |
Author | : Matilda van den Bosch |
Publisher | : Oxford University Press |
Total Pages | : 361 |
Release | : 2018-01-05 |
Genre | : Medical |
ISBN | : 019103875X |
Human beings have always been affected by their surroundings. There are various health benefits linked to being able to access to nature; including increased physical activity, stress recovery, and the stimulation of child cognitive development. The Oxford Textbook of Nature and Public Health provides a broad and inclusive picture of the relationship between our own health and the natural environment. All aspects of this unique relationship are covered, ranging from disease prevention through physical activity in green spaces to innovative ecosystem services, such as climate change adaptation by urban trees. Potential hazardous consequences are also discussed including natural disasters, vector-borne pathogens, and allergies. This book analyses the complexity of our human interaction with nature and includes sections for example epigenetics, stress physiology, and impact assessments. These topics are all interconnected and fundamental for reaching a full understanding of the role of nature in public health and wellbeing. Much of the recent literature on environmental health has primarily described potential threats from our natural surroundings. The Oxford Textbook of Nature and Public Health instead focuses on how nature can positively impact our health and wellbeing, and how much we risk losing by destroying it. The all-inclusive approach provides a comprehensive and complete coverage of the role of nature in public health, making this textbook invaluable reading for health professionals, students, and researchers within public health, environmental health, and complementary medicine.
Author | : Joseph R. Geraci |
Publisher | : National Aquarium in Baltimore |
Total Pages | : 386 |
Release | : 2005 |
Genre | : Marine mammals |
ISBN | : 0977460908 |
Comprehensive manual for understanding and carrying out marine mammal rescue activities for stranded seals, manatees, dolphins, whales, or sea otters.