Molecular Basis of Aging

Molecular Basis of Aging
Author: Alvaro Macieira-Coelho
Publisher: CRC Press
Total Pages: 577
Release: 2017-11-22
Genre: Medical
ISBN: 1351359975
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Using a new, integrative approach, Molecular Basis of Aging describes the aging phenomenon within mammalian organisms from the perspective of changes in information storage and coordination between hierarchical orders of structure. This unique approach provides the reader with a thorough insight into the evolution of molecular, cellular, tissue, and organ systems and processes in mammals. This informative volume contains up-to-date reviews of:

Molecular Basis of Aging

Molecular Basis of Aging
Author: Arun K. Roy
Publisher:
Total Pages: 424
Release: 1984
Genre: Science
ISBN:
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Molecular Basis of Aging is a collection of papers that discuss the molecular aspects of aging in the light of molecular biology, biochemical gerontology, and genetics. Each chapter of the book contains a different study about the topic, which includes the effects of aging on DNA synthesis; the amplification of extrachromosomal circular copies and mitochondrial DNA during aging; and the altered actions of hormones and neurotransmitters during aging. The book also encompasses the loss of responsiveness to growth factors in cell senescence; the integration of cellular-molecular and neuroendocrin ...

Molecular Basis of Aging

Molecular Basis of Aging
Author: A Roy
Publisher: Elsevier
Total Pages: 411
Release: 2012-12-02
Genre: Science
ISBN: 0323151558
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Molecular Basis of Aging is a collection of papers that discuss the molecular aspects of aging in the light of molecular biology, biochemical gerontology, and genetics. Each chapter of the book contains a different study about the topic, which includes the effects of aging on DNA synthesis; the amplification of extrachromosomal circular copies and mitochondrial DNA during aging; and the altered actions of hormones and neurotransmitters during aging. The book also encompasses the loss of responsiveness to growth factors in cell senescence; the integration of cellular-molecular and neuroendocrine concepts of aging; changes and inactivation of enzymes during aging; and the relationship of aging with free radicals. The text is recommended for molecular biologists, biochemists, and gerontologists who wish to study further the effects of aging on the body on a molecular level.

Molecular Basis and Emerging Strategies for Anti-aging Interventions

Molecular Basis and Emerging Strategies for Anti-aging Interventions
Author: Syed Ibrahim Rizvi
Publisher: Springer
Total Pages: 386
Release: 2018-11-02
Genre: Medical
ISBN: 9811316996
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This book describes the nature of aging, age-related disorders, and the molecular principles of emerging strategies for anti-aging interventions, while also discussing the discovery of targets for geroprotective drugs. Although significant medical advances in the treatment and eradication of life-threatening conditions such as cardiovascular and infectious disease have been made over the past five decades, the prevalence of age-related disorders still remains high in older populations. Intervening into aging is the next frontier in contemporary medicine, and will be of increasing importance over time, as other sources of poor health are combated more and more successfully. Given the universal interest in anti-aging strategies, the book will appeal to a very broad audience. It addresses a diverse range of anti-aging interventions – including stem cells, autophagy, senolytics, anti-inflammatory methods, and telomerase induction – that will be of interest to scientists and researchers from various disciplines in the life sciences.

Molecular Basis of Nutrition and Aging

Molecular Basis of Nutrition and Aging
Author: Marco Malavolta
Publisher: Academic Press
Total Pages: 786
Release: 2016-04-15
Genre: Science
ISBN: 0128018275
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Molecular Basis of Nutrition and Aging: A Volume in the Molecular Nutrition Series focuses on the nutritional issues associated with aging and the important metabolic consequences of diet, nutrition, and health. The book is subdivided into four parts that reflect the impact of nutrition from a biomolecular level to individual health. In Part One, chapters explore the general aspects of aging, aging phenotypes, and relevant aspects of nutrition related to the elderly and healthy aging. Part Two includes molecular and cellular targets of nutrition in aging, with chapters exploring lipid peroxidation, inflammaging, anabolic and catabolic signaling, epigenetics, DNA damage and repair, redox homeostasis, and insulin sensitivity, among others. Part Three looks at system-level and organ targets of nutrition in aging, including a variety of tissues, systems, and diseases, such as immune function, the cardiovascular system, the brain and dementia, muscle, bone, lung, and many others. Finally, Part Four focuses on the health effects of specific dietary compounds and dietary interventions in aging, including vitamin D, retinol, curcumin, folate, iron, potassium, calcium, magnesium, zinc, copper, selenium, iodine, vitamin B, fish oil, vitamin E, resveratrol, polyphenols, vegetables, and fruit, as well as the current nutritional recommendations. Offers updated information and a perspectives on important future developments to different professionals involved in the basic and clinical research on all major nutritional aspects of aging Explores how nutritional factors are involved in the pathogenesis of aging across body systems Investigates the molecular and genetic basis of aging and cellular senescence through the lens of the rapidly evolving field of molecular nutrition

Aging at the Molecular Level

Aging at the Molecular Level
Author: Thomas von Zglinicki
Publisher: Springer Science & Business Media
Total Pages: 249
Release: 2013-06-29
Genre: Science
ISBN: 9401706670
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During the last 40 years, the study of the biological basis of aging has progressed tremendously, and it has now become an independent and respectable field of study and research. The essential cause of aging is molecular damage that slowly overwhelms cellular and organismic defense, repair and maintenance systems. In recent years, a wealth of highly sophisticated research has transformed this idea from a credible hypothesis not only to a major theory, but essentially to accepted knowledge. Aging at the Molecular Level examines the key elements in this transformation. Bringing together contributions from an international team of authors, this volume will be of interest to graduates and postgraduates in the fields of medicine and nursing, researchers of different aspects of biogerontology and those in the pharmaceutical, cosmeceutical, nutraceutical and health-care industry.

Epigenetics of Aging

Epigenetics of Aging
Author: Trygve O. Tollefsbol
Publisher: Springer Science & Business Media
Total Pages: 462
Release: 2009-11-11
Genre: Medical
ISBN: 1441906398
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Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.

Molecular Biology of Aging

Molecular Biology of Aging
Author: Leonard Guarente
Publisher: CSHL Press
Total Pages: 610
Release: 2008
Genre: Aging
ISBN: 0879698241
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This volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among specific topics covered are calorie restriction, mitochondria, sirtuins, telomeres, stem cells, and cancer.

A Means to an End

A Means to an End
Author: William R. Clark
Publisher: Oxford University Press
Total Pages: 252
Release: 2002-02-28
Genre: Science
ISBN: 0195348397
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Why do we age? Is aging inevitable? Will advances in medical knowledge allow us to extend the human lifespan beyond its present limits? Because growing old has long been the one irreducible reality of human existence, these intriguing questions arise more often in the context of science fiction than science fact. But recent discoveries in the fields of cell biology and molecular genetics are seriously challenging the assumption that human lifespans are beyond our control. With such discoveries in mind, noted cell biologist William R. Clark clearly and skillfully describes how senescence begins at the level of individual cells and how cellular replication may be bound up with aging of the entire organism. He explores the evolutionary origin and function of aging, the cellular connections between aging and cancer, the parallels between cellular senescence and Alzheimer's disease, and the insights gained through studying human genetic disorders--such as Werner's syndrome--that mimic the symptoms of aging. Clark also explains how reduction in caloric intake may actually help increase lifespan, and how the destructive effects of oxidative elements in the body may be limited by the consumption of antioxidants found in fruits and vegetables. In a final chapter, Clark considers the social and economic aspects of living longer, the implications of gene therapy on senescence, and what we might learn about aging from experiments in cloning. This is a highly readable, provocative account of some of the most far-reaching and controversial questions we are likely to ask in the next century.