Modular Protein Domains
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Author | : Giovanni Cesareni |
Publisher | : John Wiley & Sons |
Total Pages | : 524 |
Release | : 2006-03-06 |
Genre | : Science |
ISBN | : 3527605894 |
Since the full functionality of any given protein can only be understood in terms of its interaction with other, often regulatory proteins, this unique reference source covers all relevant protein domains, including SH2, SH3, PDZ, WW, PTB, EH, PH and PX. Its user-oriented concept combines broad coverage with easy retrieval of essential information, and includes a special section on Web-based tools and databases covering protein modules and functional peptide motifs. Essential for the study of protein-protein interactions in vivo or in silico, and a prerequisite for successful functional proteomics studies. With a prologue by Sir Tom Blundell.
Author | : Jin Xiong |
Publisher | : Cambridge University Press |
Total Pages | : 360 |
Release | : 2006-03-13 |
Genre | : Science |
ISBN | : 113945062X |
Essential Bioinformatics is a concise yet comprehensive textbook of bioinformatics, which provides a broad introduction to the entire field. Written specifically for a life science audience, the basics of bioinformatics are explained, followed by discussions of the state-of-the-art computational tools available to solve biological research problems. All key areas of bioinformatics are covered including biological databases, sequence alignment, genes and promoter prediction, molecular phylogenetics, structural bioinformatics, genomics and proteomics. The book emphasizes how computational methods work and compares the strengths and weaknesses of different methods. This balanced yet easily accessible text will be invaluable to students who do not have sophisticated computational backgrounds. Technical details of computational algorithms are explained with a minimum use of mathematical formulae; graphical illustrations are used in their place to aid understanding. The effective synthesis of existing literature as well as in-depth and up-to-date coverage of all key topics in bioinformatics make this an ideal textbook for all bioinformatics courses taken by life science students and for researchers wishing to develop their knowledge of bioinformatics to facilitate their own research.
Author | : |
Publisher | : |
Total Pages | : 0 |
Release | : 2002 |
Genre | : Cells |
ISBN | : 9780815332183 |
Author | : Lei Yang |
Publisher | : Academic Press |
Total Pages | : 364 |
Release | : 2018-11-30 |
Genre | : Technology & Engineering |
ISBN | : 012813478X |
Biomaterials in Translational Medicine delivers timely and detailed information on the latest advances in biomaterials and their role and impact in translational medicine. Key topics addressed include the properties and functions of these materials and how they might be applied for clinical diagnosis and treatment. Particular emphasis is placed on basic fundamentals, biomaterial formulations, design principles, fabrication techniques and transitioning bench-to-bed clinical applications. The book is an essential reference resource for researchers, clinicians, materials scientists, engineers and anyone involved in the future development of innovative biomaterials that drive advancement in translational medicine. - Systematically introduces the fundamental principles, rationales and methodologies of creating or improving biomaterials in the context of translational medicine - Includes the translational or commercialization status of these new biomaterials - Provides the reader with enough background knowledge for a fundamental grip of the difficulties and technicalities of using biomaterial translational medicine - Directs the reader on how to find other up-to-date sources (i.e. peer reviewed journals) in the field of translational medicine and biomaterials
Author | : Wolfgang Maret |
Publisher | : Royal Society of Chemistry |
Total Pages | : 990 |
Release | : 2014-07-09 |
Genre | : Science |
ISBN | : 1782622829 |
Metal ions play key roles in biology. Many are essential for catalysis, for electron transfer and for the fixation, sensing, and metabolism of gases. Others compete with those essential metal ions or have toxic or pharmacological effects. This book is structured around the periodic table and focuses on the control of metal ions in cells. It addresses the molecular aspects of binding, transport and storage that ensure balanced levels of the essential elements. Organisms have also developed mechanisms to deal with the non-essential metal ions. However, through new uses and manufacturing processes, organisms are increasingly exposed to changing levels of both essential and non-essential ions in new chemical forms. They may not have developed defenses against some of these forms (such as nanoparticles). Many diseases such as cancer, diabetes and neurodegeneration are associated with metal ion imbalance. There may be a deficiency of the essential metals, overload of either essential or non-essential metals or perturbation of the overall natural balance. This book is the first to comprehensively survey the molecular nature of the overall natural balance of metal ions in nutrition, toxicology and pharmacology. It is written as an introduction to research for students and researchers in academia and industry and begins with a chapter by Professor R J P Williams FRS.
Author | : Kuriyan, John |
Publisher | : W.W. Norton & Company |
Total Pages | : 15 |
Release | : 2012-07-25 |
Genre | : Science |
ISBN | : 0815341881 |
This textbook provides an integrated physical and biochemical foundation for undergraduate students majoring in biology or health sciences. It is particularly suitable for students planning to enter the pharmaceutical industry. This new generation of molecular biologists and biochemists will harness the tools and insights of physics and chemistry to exploit the emergence of genomics and systems-level information in biology, and will shape the future of medicine.
Author | : Jacqueline M. Matthews |
Publisher | : Springer Science & Business Media |
Total Pages | : 184 |
Release | : 2012-09-04 |
Genre | : Medical |
ISBN | : 1461432294 |
This volume has a strong focus on homo-oligomerization, which is surprisingly common. However, protein function is so often linked to both homo- and hetero-oligomerization and many heterologous interactions likely evolved from homologous interaction, so this volume also covers many aspects of hetero-oligomerization.
Author | : Anthony J. Pawson |
Publisher | : Springer Science & Business Media |
Total Pages | : 375 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 3642804810 |
This volume in the series Current Topics in Microbiology and Immunology focuses on protein modules in signal transduction. Topics covered include: functions of SH2 and SH3 domains; structure and function of LIM domains; and the IRS-signalling system.
Author | : Jennifer J. McManus |
Publisher | : Humana |
Total Pages | : 266 |
Release | : 2020-08-08 |
Genre | : Science |
ISBN | : 9781493996803 |
This volume explores experimental and computational approaches to measuring the most widely studied protein assemblies, including condensed liquid phases, aggregates, and crystals. The chapters in this book are organized into three parts: Part One looks at the techniques used to measure protein-protein interactions and equilibrium protein phases in dilute and concentrated protein solutions; Part Two describes methods to measure kinetics of aggregation and to characterize the assembled state; and Part Three details several different computational approaches that are currently used to help researchers understand protein self-assembly. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Protein Self-Assembly: Methods and Protocols is a valuable resource for researchers who are interested in learning more about this developing field.
Author | : Gregory A. Petsko |
Publisher | : New Science Press |
Total Pages | : 220 |
Release | : 2004 |
Genre | : Proteins |
ISBN | : 0878936637 |
Each title in the 'Primers in Biology' series is constructed on a modular principle that is intended to make them easy to teach from, to learn from, and to use for reference.