Models Of Scientific Development And The Case Of Nuclear Magnetic Resonance
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Author | : Henk Zandvoort |
Publisher | : Springer Science & Business Media |
Total Pages | : 318 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 940094764X |
From the nineteen sixties onwards a branch of philosophy of science has come to development, called history-oriented philosophy of science. This development constitutes a reaction on the then prevailing logical empiricist conception of scientific knowledge. The latter was increasingly seen as suffering from insurmountable internal problems, like e. g. the problems with the particular "observational-theoretical distinction" on which it drew. In addition the logical empiricists' general approach was increasingly criticized for two external shortcomings. Firstly, the examples of scientific knowledge that the logical empiricists were focusing on were con sidered as too simplistic to be informative on the nature of real life science. Secondly, it was felt that the attention of these philosophers of science was restricted to the static aspects of scientific knowledge, while neglecting its developmental aspects. History-oriented philosophy of science has taken up the challenge implicit in the latter two criticisms, i. e. to develop accounts of science that would be more adequate for understanding the development 1 of real life science. One of the more successful products of this branch of philosophy of science is Lakatos's theory of scientific development, sometimes called the "methodology of scientific research programmes". This theory conceives science as consisting of so called research program mes developing in time, and competing with each other over the issue which one generates the best explan~tions of the phenomena that they address.
Author | : Henk Zandvoort |
Publisher | : |
Total Pages | : 324 |
Release | : 1986-09-30 |
Genre | : |
ISBN | : 9789400947658 |
Author | : John L. Markley |
Publisher | : Oxford University Press |
Total Pages | : 375 |
Release | : 1997-01-30 |
Genre | : Medical |
ISBN | : 0195094689 |
This book presents a critical assessment of progress on the use of nuclear magnetic resonance spectroscopy to determine the structure of proteins, including brief reviews of the history of the field along with coverage of current clinical and in vivo applications. The book, in honor of Oleg Jardetsky, one of the pioneers of the field, is edited by two of the most highly respected investigators using NMR, and features contributions by most of the leading workers in the field. It will be valued as a landmark publication that presents the state-of-the-art perspectives regarding one of today's most important technologies.
Author | : The Nuclear Magnetic Resonance Society of Japan |
Publisher | : Springer |
Total Pages | : 634 |
Release | : 2017-11-23 |
Genre | : Science |
ISBN | : 9811059667 |
This book describes the advanced developments in methodology and applications of NMR spectroscopy to life science and materials science. Experts who are leaders in the development of new methods and applications of life and material sciences have contributed an exciting range of topics that cover recent advances in structural determination of biological and material molecules, dynamic aspects of biological and material molecules, and development of novel NMR techniques, including resolution and sensitivity enhancement. First, this book particularly emphasizes the experimental details for new researchers to use NMR spectroscopy and pick up the potentials of NMR spectroscopy. Second, the book is designed for those who are involved in either developing the technique or expanding the NMR application fields by applying them to specific samples. Third, the Nuclear Magnetic Resonance Society of Japan has organized this book not only for NMR members of Japan but also for readers worldwide who are interested in using NMR spectroscopy extensively.
Author | : Bernhard Blümich |
Publisher | : Walter de Gruyter GmbH & Co KG |
Total Pages | : 305 |
Release | : 2014-08-22 |
Genre | : Technology & Engineering |
ISBN | : 3110374587 |
The goal of this book is to provide an introduction to the practical use of mobile NMR at a level as basic as the operation of a smart phone. Each description follows the same didactic pattern: introduction, basic theory, pulse sequences and parameters, beginners-level measurements, advanced-level measurements, and data processing. Nuclear Magnetic Resonance (NMR) spectroscopy is the most popular method for chemists to analyze molecular structures while Magnetic Resonance Imaging (MRI) is a non-invasive diagnostic tool for medical doctors that provides high-contrast images of biological tissue depicting the brain function and the beating heart. In both applications large super-conducting magnets are employed which magnetize atomic nuclei of an object positioned inside the magnet. Their circulating motion is interrogated by radio-frequency waves. Depending on the operating mode, the frequency spectrum provides the chemist with molecular information, the medical doctor with anatomic images, while the materials scientist is interested in NMR relaxation parameters, which scale with material properties and determine the contrast in magnetic resonance images. Recent advances in magnet technology led to a variety of small permanent magnets, by which NMR spectra, images, and relaxation parameters can be measured with mobile and low-cost instruments.
Author | : T. Claridge |
Publisher | : Elsevier |
Total Pages | : 408 |
Release | : 1999-12-24 |
Genre | : Science |
ISBN | : 9780080427997 |
From the initial observation of proton magnetic resonance in water and in paraffin, the discipline of nuclear magnetic resonance has seen unparalleled growth as an analytical method. Modern NMR spectroscopy is a highly developed, yet still evolving, subject which finds application in chemistry, biology, medicine, materials science and geology. In this book, emphasis is on the more recently developed methods of solution-state NMR applicable to chemical research, which are chosen for their wide applicability and robustness. These have, in many cases, already become established techniques in NMR laboratories, in both academic and industrial establishments. A considerable amount of information and guidance is given on the implementation and execution of the techniques described in this book.
Author | : Atta-ur-Rahman |
Publisher | : Bentham Science Publishers |
Total Pages | : 289 |
Release | : 2016-11-22 |
Genre | : Science |
ISBN | : 168108287X |
Applications of NMR Spectroscopy is a book series devoted to publishing the latest advances in the applications of nuclear magnetic resonance (NMR) spectroscopy in various fields of organic chemistry, biochemistry, health and agriculture. The fifth volume of the series features several reviews focusing on NMR spectroscopic techniques for identifying natural and synthetic compounds (polymer and peptide characterization, GABA in tinnitus affected mice), medical diagnosis and therapy (gliomas) and food analysis. The spectroscopic methods highlighted in this volume include high resolution proton magnetic resonance spectroscopy and solid state NMR.
Author | : Dmitry Budker |
Publisher | : Cambridge University Press |
Total Pages | : 431 |
Release | : 2013-03-07 |
Genre | : Science |
ISBN | : 1107010357 |
Comprehensive coverage of the principles, technology and diverse applications of optical magnetometry for graduate students and researchers in atomic physics.
Author | : Dennis A. Hansell |
Publisher | : Academic Press |
Total Pages | : 712 |
Release | : 2014-10-02 |
Genre | : Science |
ISBN | : 0124071538 |
Marine dissolved organic matter (DOM) is a complex mixture of molecules found throughout the world's oceans. It plays a key role in the export, distribution, and sequestration of carbon in the oceanic water column, posited to be a source of atmospheric climate regulation. Biogeochemistry of Marine Dissolved Organic Matter, Second Edition, focuses on the chemical constituents of DOM and its biogeochemical, biological, and ecological significance in the global ocean, and provides a single, unique source for the references, information, and informed judgments of the community of marine biogeochemists. Presented by some of the world's leading scientists, this revised edition reports on the major advances in this area and includes new chapters covering the role of DOM in ancient ocean carbon cycles, the long term stability of marine DOM, the biophysical dynamics of DOM, fluvial DOM qualities and fate, and the Mediterranean Sea. Biogeochemistry of Marine Dissolved Organic Matter, Second Edition, is an extremely useful resource that helps people interested in the largest pool of active carbon on the planet (DOC) get a firm grounding on the general paradigms and many of the relevant references on this topic. - Features up-to-date knowledge of DOM, including five new chapters - The only published work to synthesize recent research on dissolved organic carbon in the Mediterranean Sea - Includes chapters that address inputs from freshwater terrestrial DOM
Author | : Clarence H. Suelter |
Publisher | : Wiley-Interscience |
Total Pages | : 310 |
Release | : 1991-01-16 |
Genre | : Science |
ISBN | : 9780471513261 |
Presents methods for determining the secondary and tertiary structure of proteins. The issues covered here involve theoretical/empirical approaches for predicting protein structure; a review using protein ligand interactions to study surface properties of proteins; use of fluorescence techniques to study structure and dynamics of proteins; and limited proteolysis with monoclonal antibodies to understand how specific structural features confer biological function.