Microglia in the Regenerating and Degenerating Central Nervous System

Microglia in the Regenerating and Degenerating Central Nervous System
Author: Wolfgang J. Streit
Publisher: Springer Science & Business Media
Total Pages: 364
Release: 2002-01-08
Genre: Science
ISBN: 9780387953014

The study of microglial cells has recently gained importance for those researching degeneration and regeneration. Microglia in the regenerating and degenerating CNS supports the assertion that understanding microglial biology could perhaps be pivotal for unraveling the pathogenetic mechanisms that underlie Alzheimer's disease, In addition, microglia are also critical for understanding the sequelae of traumatic brain and spinal cord injury, and for the important post-traumatic repair processes. This book gives an up to date account of the role of microglia in degeneration and regeneration of the nervous system and reviews their cell function and physiology.

Microglia in the Regenerating and Degenerating Central Nervous System

Microglia in the Regenerating and Degenerating Central Nervous System
Author: Wolfgang J. Streit
Publisher: Springer Science & Business Media
Total Pages: 326
Release: 2013-03-14
Genre: Science
ISBN: 1475741391

The study of microglial cells has recently gained importance for those researching degeneration and regeneration. Microglia in the regenerating and degenerating CNS supports the assertion that understanding microglial biology could perhaps be pivotal for unraveling the pathogenetic mechanisms that underlie Alzheimer's disease, In addition, microglia are also critical for understanding the sequelae of traumatic brain and spinal cord injury, and for the important post-traumatic repair processes. This book gives an up to date account of the role of microglia in degeneration and regeneration of the nervous system and reviews their cell function and physiology.

Cajal's Degeneration and Regeneration of the Nervous System

Cajal's Degeneration and Regeneration of the Nervous System
Author: Santiago Ramón y Cajal
Publisher: History of Neuroscience
Total Pages: 977
Release: 1991
Genre: Nervous system
ISBN: 0195065166

This book is a reprint of an English translation of Cajal's original work, with abundant notes and commentaries by the editor. This text describes Cajal's fundamental contributions to neuroscience, which continue to be important today. It accurately details Cajal's ideas and data, and providesreaders with the opportunity to learn what Cajal thought about his research career and the significance of his observations. Excerpts from Tello's memorial lectures also provide a contemporary view of Cajal's work.

Indwelling Neural Implants

Indwelling Neural Implants
Author: William M. Reichert
Publisher: CRC Press
Total Pages: 300
Release: 2007-12-17
Genre: Medical
ISBN: 1420009303

Despite enormous advances made in the development of external effector prosthetics over the last quarter century, significant questions remain, especially those concerning signal degradation that occurs with chronically implanted neuroelectrodes. Offering contributions from pioneering researchers in neuroprosthetics and tissue repair, Indwel

Apoptosis and Beyond

Apoptosis and Beyond
Author: James A. Radosevich
Publisher: John Wiley & Sons
Total Pages: 768
Release: 2018-09-18
Genre: Science
ISBN: 1119432359

These volumes teach readers to think beyond apoptosis and describes all of the known processes that cells can undergo which result in cell death This two-volume source on how cells dies is the first, comprehensive collection to cover all of the known processes that cells undergo when they die. It is also the only one of its kind to compare these processes. It seeks to enlighten those in the field about these many processes and to stimulate their thinking at looking at these pathways when their research system does not show signs of activation of the classic apoptotic pathway. In addition, it links activities like the molecular biology of one process (eg. Necrosis) to another process (eg. apoptosis) and contrasts those that are close to each. Volume 1 of Apoptosis and Beyond: The Many Ways Cells Die begins with a general view of the cytoplasmic and nuclear features of apoptosis. It then goes on to offer chapters on targeting the cell death mechanism; microbial programmed cell death; autophagy; cell injury, adaptation, and necrosis; necroptosis; ferroptosis; anoikis; pyronecrosis; and more. Volume 2 covers such subjects as phenoptosis; pyroptosis; hematopoiesis and eryptosis; cyclophilin d-dependent necrosis; and the role of phospholipase in cell death. Covers all known processes that dying cells undergo Provides extensive coverage of a topic not fully covered before Offers chapters written by top researchers in the field Provides activities that link and contrast processes to each other Apoptosis and Beyond: The Many Ways Cells Die will appeal to students and researchers/clinicians in cell biology, molecular biology, oncology, and tumor biology.

Never-resting microglia: physiological roles in the healthy brain and pathological implications

Never-resting microglia: physiological roles in the healthy brain and pathological implications
Author: Amanda Sierra
Publisher: Frontiers E-books
Total Pages: 173
Release: 2015-02-11
Genre: Microglia
ISBN: 2889193691

Microglia are largely known as the major orchestrators of the brain inflammatory response. As such, they have been traditionally studied in various contexts of disease, where their activation has been assumed to induce a wide range of detrimental effects. In the last few years, a series of discoveries have challenged the current view of microglia, showing their active and positive contribution to normal brain function. This Research Topic reviewed the novel physiological roles of microglia in the developing, mature and aging brain, under non-pathological conditions. In particular, this Research Topic discussed the cellular and molecular mechanisms by which microglia contribute to the formation, pruning and plasticity of synapses; the regulation of adult neurogenesis as well as hippocampal learning and memory; among other important roles. Because these novel findings defy our understanding of microglial function in health as much as in disease, this Research Topic also summarized the current view of microglial nomenclature, phenotypes, origin and differentiation, and contribution to various brain pathologies. Additionally, novel imaging approaches and molecular tools to study microglia in their non-activated state have been discussed. In conclusion, this Research Topic seeked to emphasize how the current research in neuroscience is challenged by never-resting microglia.

Degeneration and Regeneration in the Nervous System

Degeneration and Regeneration in the Nervous System
Author: Norman Saunders
Publisher: CRC Press
Total Pages: 354
Release: 2003-09-02
Genre: Medical
ISBN: 0203304489

Degeneration and Regeneration in the Nervous System brings together an international team of contributors to produce a series of critical reviews appraising key papers in the field. The pace of research on brain and spinal cord injury quickened considerably in the last ten years and there is much that is new and important that is covered in this book. However, there is still a long way to go before our knowledge will explain fully why the central nervous system has such a limited capacity for regeneration, and before experimental solutions can be applied to the patient. With emphasis on actual and therapeutic importance of the work reviewed, Degeneration and Regeneration in the Nervous System is a useful overview for graduate students, their teachers and researchers working in this field.

Cellular and Molecular Biology of Autism Spectrum Disorders

Cellular and Molecular Biology of Autism Spectrum Disorders
Author: Anna Strunecká
Publisher: Bentham Science Publishers
Total Pages: 232
Release: 2010-12-24
Genre: Science
ISBN: 160805196X

"Over the past several decades the incidence of autism spectrum disorders (ASD) has increased dramatically. The etiology of ASD remains an unsolved puzzle to scientists, physicians, pediatricians, psychiatrists, and pharmacologists. Our E-book will address"

Leucine-Rich Repeat Kinase 2 (LRRK2)

Leucine-Rich Repeat Kinase 2 (LRRK2)
Author: Hardy J. Rideout
Publisher: Springer
Total Pages: 280
Release: 2017-03-28
Genre: Medical
ISBN: 3319499696

This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.

The Role of Glia in Neurotoxicity

The Role of Glia in Neurotoxicity
Author: Michael Aschner
Publisher: CRC Press
Total Pages: 477
Release: 2004-12-28
Genre: Medical
ISBN: 1420039741

Presenting the latest research in glial cell function gleaned from new techniques in imaging and molecular biology, The Role of Glia in Neurotoxicity, Second Edition covers multiple aspects of glial cells, including morphology, physiology, pharmacology, biochemistry, pathology, and their involvement in the pathophysiology of neurological diseases.