Microcalorimetry Of Macromolecules
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| Author | : Peter L. Privalov |
| Publisher | : John Wiley & Sons |
| Total Pages | : 420 |
| Release | : 2012-05-29 |
| Genre | : Science |
| ISBN | : 1118337492 |
Examining the physical basis of the structure of macromolecules—proteins, nucleic acids, and their complexes—using calorimetric techniques Many scientists working in biology are unfamiliar with the basics of thermodynamics and its role in determining molecular structures. Yet measuring the heat of structural change a molecule undergoes under various conditions yields information on the energies involved and, thus, on the physical bases of the considered structures. Microcalorimetry of Macromolecules offers protein scientists unique access to this important information. Divided into thirteen chapters, the book introduces readers to the basics of thermodynamics as it applies to calorimetry, the evolution of the calorimetric technique, as well as how calorimetric techniques are used in the thermodynamic studies of macromolecules, detailing instruments for measuring the heat effects of various processes. Also provided is general information on the structure of biological macromolecules, proteins, and nucleic acids, focusing on the key thermodynamic problems relating to their structure. The book covers: The use of supersensitive calorimetric instruments, including micro and nano-calorimeters for measuring the heat of isothermal reactions (Isothermal Titration Nano-Calorimeter), the heat capacities over a broad temperature range (Scanning Nano-Calorimeter), and pressure effects (Pressure Perturbation Nano-Calorimeter) Two of the simplest but key structural elements: the α and polyproline helices and their complexes, the α-helical coiled-coil, and the pyroline coiled-coils Complicated macromolecular formations, including small globular proteins, multidomain proteins and their complexes, and nucleic acids Numerous examples of measuring the ground state of protein energetics, as well as changes seen when proteins interact The book also reveals how intertwined structure and thermodynamics are in terms of a macromolecule's organization, mechanism of formation, the stabilization of its three-dimensional structure, and ultimately, its function. The first book to describe microcalorimetric technique in detail, enough for graduate students and research scientists to successfully plumb the structural mysteries of proteins and the double helix, Microcalorimetry of Macromolecules is an essential introduction to using a microcalorimeter in biological studies.
| Author | : Amal Ali Elkordy |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 488 |
| Release | : 2013-01-23 |
| Genre | : Science |
| ISBN | : 9535109472 |
Calorimetry, as a technique for thermal analysis, has a wide range of applications which are not only limited to studying the thermal characterisation (e.g. melting temperature, denaturation temperature and enthalpy change) of small and large drug molecules, but are also extended to characterisation of fuel, metals and oils. Differential Scanning Calorimetry is used to study the thermal behaviours of drug molecules and excipients by measuring the differential heat flow needed to maintain the temperature difference between the sample and reference cells equal to zero upon heating at a controlled programmed rate. Microcalorimetry is used to study the thermal transition and folding of biological macromolecules in dilute solutions. Microcalorimetry is applied in formulation and stabilisation of therapeutic proteins. This book presents research from all over the world on the applications of calorimetry on both solid and liquid states of materials.
| Author | : Eric Ennifar |
| Publisher | : Humana |
| Total Pages | : 0 |
| Release | : 2019-04-01 |
| Genre | : Science |
| ISBN | : 9781493991785 |
This volume provides methods on microcalorimetry approaches to investigate complex biological molecular systems. Chapters guide readers through Differential Scanning Calorimetry (DSC), Isothermal Titration Calorimetry (ITC), and advanced data processing. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Microcalorimetry of Biological Molecules: Methods and Protocols aims to ensure successful results in the further study of this vital field.
| Author | : Sergio Carrà |
| Publisher | : EOLSS Publications |
| Total Pages | : 480 |
| Release | : 2009-05-05 |
| Genre | : |
| ISBN | : 1905839588 |
Fundamentals of Chemistry theme in two volumes, is a component of Encyclopedia of Chemical Sciences, Engineering and Technology Resources in the global Encyclopedia of Life Support Systems (EOLSS), which is an integrated compendium of twenty one Encyclopedias. The Theme is organized into six different topics which represent the main scientific areas : History and Fundamentals of Chemistry; Chemical Experimentation and Instrumentation; Theoretical Approach to Chemistry; Chemical Thermodynamics; Rates of Chemical Reactions; Chemical Synthesis of Substances. These two volumes are aimed at the following five major target audiences: University and College students Educators, Professional practitioners, Research personnel and Policy analysts, managers, and decision makers and NGOs
| Author | : Zhiqun Lin |
| Publisher | : Springer |
| Total Pages | : 717 |
| Release | : 2017-06-16 |
| Genre | : Technology & Engineering |
| ISBN | : 331957003X |
This book provides a comprehensive overview of engineering nanostructures mediated by functional polymers in combination with optimal synthesis and processing techniques. The focus is on polymer-engineered nanostructures for advanced energy applications. It discusses a variety of polymers that function as precursors, templates, nano-reactors, surfactants, stabilizers, modifiers, dopants, and spacers for directing self-assembly, assisting organization, and templating growth of numerous diverse nanostructures. It also presents a wide range of polymer processing techniques that enable the efficient design and optimal fabrication of nanostructured polymers, inorganics, and organic–inorganic nanocomposites using in-situ hybridization and/or ex-situ recombination methodologies. Combining state-of-the-art knowledge from polymer-guided fabrication of advanced nanostructures and their unique properties, it especially highlights the new, cutting-edge breakthroughs, future horizons, and insights into such nanostructured materials in applications such as photovoltaics, fuel cells, thermoelectrics, piezoelectrics, ferroelectrics, batteries, supercapacitors, photocatalysis, and hydrogen generation and storage. It offers an instructive and approachable guide to polymer-engineered nanostructures for further development of advanced energy materials to meet ever-increasing global energy demands. Interdisciplinary and broad perspectives from internationally respected contributors ensure this book serves as a valuable reference source for scientists, students, and engineers working in polymer science, renewable energy materials, materials engineering, chemistry, physics, surface/interface science, and nanotechnology. It is also suitable as a textbook for universities, institutes, and industrial institutions.
| Author | : Mukesh Kumar Singh |
| Publisher | : Woodhead Publishing |
| Total Pages | : 507 |
| Release | : 2021-09-19 |
| Genre | : Technology & Engineering |
| ISBN | : 0128242396 |
Characterization of Polymers and Fibres addresses an integral part of fiber and polymer manufacturing processes that is crucial in helping manufacturers ensure that final products achieve intended specifications. The characterization of fiber and polymers is needed for attributes including molecular weight, morphology, dyeing behavior, tensile, optical and thermal behavior. This book covers a wide range of characterization techniques, including thermal, X-ray diffraction, solubility, tensile, optical, hygroscopic and particle size distribution. Introductions and definitions are provided where beneficial to make topics accessible to a broad range of readers in both academia and industry. Addressing advances from the fields of bioscience, polymer science, material science, and textile science, this book is wide in scope, drawing on the latest research to provide details of characterization techniques and equipment. - Provides a thorough description of the material quality control process, including the latest industry practice - Presents material characterization at all levels, from the atomic level to surface structure - Covers technical advice on natural fiber characterization methods, including XRD, XPS, TGA, SEM, TEM, AFM, Contact angle, Particle size analysis, FTIR, and NMR
| Author | : |
| Publisher | : Elsevier |
| Total Pages | : 581 |
| Release | : 2000-08-09 |
| Genre | : Science |
| ISBN | : 0080496784 |
Volume 323 of Methods in Enzymology is dedicated to the energetics of biological macromolecules. Understanding the molecular mechanisms underlying a biological process requires detailed knowledge of the structural relationships within the system and an equally detailed understanding of the energetic driving forces that control the structural interactions. This volume presents modern thermodynamic techniques currently being utilized to study the energetic driving forces in biological systems. It will be a useful reference source and textbook for scientists and students whose goal is to understand the energetic relationships between macromoleculer structures and biological functions. This volume supplements Volumes 259 and Volume 295 of Methods in Enzymology.Key Features* Probing Stability of Helical Transmembrane Proteins* Energetics of Vinca Alkaloid Interactions with Tubulin* Deriving Complex Ligand Binding Formulas* Mathematical Modeling of Cooperative Interactions in Hemoglobin* Analysis of Interactions of Regulatory Protein TyrR with DNA* Parsing Free Energy of Drug-DNA Interactions* Use of Fluorescence as Thermodynamics Tool
| Author | : Osama M. Musa |
| Publisher | : John Wiley & Sons |
| Total Pages | : 2665 |
| Release | : 2021-07-06 |
| Genre | : Science |
| ISBN | : 1119468736 |
HANDBOOK OF PYRROLIDONE AND CAPROLACTAM BASED MATERIALS Brings together, for the first time, a comprehensive review of all aspects of pyrrolidone- and caprolactam-based materials This comprehensive, six-volume set describes the broad technical universe of γ- and ε- lactams, reviewing in-depth the chemistry of the small lactam-based molecules, uncovering their unique properties and showing how they have enabled a myriad of commercially important applications. From synthesis, through production and into applications, this extensive work targets significant and recent trends in γ- and ε-lactam science and technology and addresses all key aspects of pyrrolidone- and caprolactam-based materials to produce a definitive overview of the field. Handbook of Pyrrolidone and Caprolactam Based Materials provides a detailed and modern portrait of the impact of pyrrolidone- and caprolactam-based materials on the world, as well as potential future possibilities. Volume One presents the chemistry of small lactam-based molecules and uncovers their unique properties. Volume Two covers polymeric materials, including polyvinyl pyrrolidone and polyvinyl caprolactam, and reviews homopolymerization, copolymerization, controlled radical polymermization and acrylate based pyrrolidone polymerizations. Volume Three examines the physical chemistry and molecular interactions of pyrrolidone and caprolactam based materials. Volume Four expands upon the characterization theme from the third volume, and includes detailed discussions of nuclear magnetic resonance (NMR) and Fourier transform-infrared (FT-IR) spectroscopy, thermal and mechanical properties, and imaging techniques. Volume Five explores pharmaceutical applications in both ingredients and materials, as well as the antimicrobial properties and applications of pyrrolidone and caprolactam-based materials, and their toxicology. Volume Six covers personal and home care, skin care, transdermal applications and wound care, oral care, adhesion related applications and digital applications such as inkjet technology. Handbook of Pyrrolidone and Caprolactam Based Materials will appeal to industrial scientists and engineers interested in polymer development and manufacturing. It will also benefit academic researchers working in the fields of chemistry, materials science, and chemical and process engineering.
| Author | : Vitaliy V. Khutoryanskiy |
| Publisher | : John Wiley & Sons |
| Total Pages | : 406 |
| Release | : 2018-08-20 |
| Genre | : Technology & Engineering |
| ISBN | : 1119157781 |
An authoritative resource that offers an understanding of the chemistry, properties and applications of temperature-responsive polymers With contributions from a distinguished panel of experts, Temperature-Responsive Polymers puts the focus on hydrophilic polymers capable of changing their physicochemical properties in response to changes in environmental temperature. The contributors review the chemistry of these systems, and discuss a variety of synthetic approaches for preparation of temperature-responsive polymers, physicochemical methods of their characterisation and potential applications in biomedical areas. The text reviews a wide-variety of topics including: The characterisation of temperature-responsive polymers; Infrared and Raman spectroscopy; Applications of temperature-responsive polymers grafted onto solid core nanoparticles; and much more. The contributors also explore how temperature-responsive polymers can be used in the biomedical field for applications such as tissue engineering. This important resource: Offers an important synthesis of the current research on temperature-responsive polymers Covers the chemistry, the synthetic approaches for presentation and the physiochemical method of temperature-responsive polymers Includes a review of the fundamental characteristics of temperature-responsive polymers Explores many of the potential applications in biomedical science, including drug delivery and gene therapy Written for polymer scientists in both academia and industry as well as postgraduate students working in the area of stimuli-responsive materials, this vital text offers an exploration of the chemistry, properties and current applications of temperature-responsive polymers.
| Author | : Geoffrey A. Holdgate |
| Publisher | : John Wiley & Sons |
| Total Pages | : 309 |
| Release | : 2024-04-09 |
| Genre | : Medical |
| ISBN | : 1394179790 |
Understand how drug discovery incorporates the building blocks of complex life with this accessible guide Enzymes are among the fundamental building blocks of life, the proteins that catalyze some of the most important metabolic and biochemical reactions that sustain the complex organism. Understanding the unique structures and mechanisms of individual enzymes is key to medical treatment and pharmaceutical intervention, making it an especially essential aspect of drug discovery. The topic can appear challenging, however, as it requires command of interdisciplinary research combining biology, chemistry, and mathematics. Laboratory Guide to Enzymology brings these disciplines together to offer a practical, accessible overview of the lab-based work of creating effective enzyme essays. Beginning with a guide to the fundamentals of enzyme theory, the book connects that theory to a range of modern methods of computation and experimentation. The result is a detailed but highly readable volume elucidating the cornerstone of drug discovery research. Laboratory Guide to Enzymology readers will also find: Specific examples of enzyme application in drug discovery Detailed discussion of topics including enzyme catalysis, chemical kinetics, steady-state assays, and many more Appendices including a range of vital supplementary material Laboratory Guide to Enzymology is ideal for all biomedical and pharmaceutical researchers working in enzymology and assay development, as well as advanced students in the biomedical or biochemical sciences looking to develop a working knowledge of this field of research.
