Microarrays For The Neurosciences
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Author | : Daniel H. Geschwind |
Publisher | : MIT Press |
Total Pages | : 366 |
Release | : 2002 |
Genre | : DNA microarrays |
ISBN | : 9780262072298 |
The effort to sequence the human genome has generated a new discipline, functional genomics, or the study of the relationship between the genetic code and its biologic potential. Gene expression studies are made possible not only by the decoding of the human genome, but by the development of new technologies. The preeminent technology in this area, DNA microarrays, is helping to revolutionize the field of neuroscience.
Author | : |
Publisher | : Elsevier |
Total Pages | : 218 |
Release | : 2004-12-10 |
Genre | : Medical |
ISBN | : 0080495516 |
DNA array technology is a technique for studying gene expression by comparing samples of different genes. The result is an enormous amount of data that must be carefully analyzed in order for it to be useful and meaningful. This book examines both data analysis and techniques for ensuring optimal experimental conditions. The array approach has applications in a number of model systems, including development, learning and drug abuse. In addition, the technique has applications in a number of neurological disorders such as Alzheimer's disease, schizophrenia, multiple sclerosis, and neurological cancers.
Author | : Elena V. Grigorenko |
Publisher | : CRC Press |
Total Pages | : 183 |
Release | : 2001-12-21 |
Genre | : Science |
ISBN | : 1420038850 |
A quantum leap in technology took place a few years ago with the introduction of cDNA arrays that have been developed in response to the need for simultaneous analysis of the patterns of expression of thousands of genes. DNA Arrays: Technologies and Experimental Strategies offers a view of different aspects of this rapidly developing technology, in
Author | : Hemin R. Chin |
Publisher | : CRC Press |
Total Pages | : 432 |
Release | : 2001-09-26 |
Genre | : Science |
ISBN | : 100061171X |
The past few years have witnessed extraordinary advances in molecular genetic techniques and the accumulation of structural genomics information and resources in both human and model organisms. With the development of new technologies and the availability of resources like the sequence of eukaryotic genomes, problems of a previously unthinkable sco
Author | : Gary Hardiman |
Publisher | : CRC Press |
Total Pages | : 314 |
Release | : 2019-08-30 |
Genre | : |
ISBN | : 9780367385811 |
In recent years, high-density DNA microarrays have revolutionized biomedical research and drug discovery efforts by the pharmaceutical industry. Their efficacy in identifying and prioritizing drug targets based on their ability to confirm a large number of gene expression measurements in parallel has become a key element in drug discovery. Microarray Innovations: Technology and Experimentation examines the incredibly powerful nature of array technology and the ways in which it can be applied to understanding the genomic basis of disease. Explores a myriad of applications in use today This volume explores recent innovations in the microarray field and tracks the evolution of the major platforms currently used. The international panel of contributors presents a survey of the past five years' research and advancements in microarray methods and applications and their usage in drug discovery and biomedical research. The contributions discuss improvements in automation (array fabrication and hybridization), new substrates for printing arrays, platform comparisons and contrasts, experimental design, and data normalization and mining schemes. They also review epigenomic array studies, electronic microarrays, comparative genomic hybridization, microRNA arrays, and mutational analyzes. In addition, the book provides coverage of important clinical diagnostic arrays, protein arrays, and neuroscience applications. Examines improved methodologies As microarrays have evolved steadily over time from archetypical in-house complementary DNA (cDNA) arrays to robust commercial oligonucleotide platforms, there has been a migration to higher density biochips with increasing content and better analytical methodologies. This compendium summarizes the vast advances that have been made in this technology, highlighting the supreme advantages of microarray-based appro
Author | : Mark Schena |
Publisher | : Scion Publishing Ltd |
Total Pages | : 289 |
Release | : 2007-10-01 |
Genre | : Science |
ISBN | : 1907904395 |
DNA Microarrays: Methods Express covers the very latest in DNA microarray technology, with a clear focus on how these techniques can be used in the lab to gain the very best results. The authors are from some of the leading laboratories in the field and write with real authority on the latest methodology. Every chapter provides detailed step-by-step protocols with valuable hints and tips for success, as well as giving typical experimental results and selected literature citations. This book is a 'must have' manual for researchers in all fields of biology, medicine and agriculture.
Author | : Jacques Mallet |
Publisher | : Springer Science & Business Media |
Total Pages | : 194 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 3642555438 |
In this new volume in the series Research and Perspectives in Neurosciences the authors have presented and discussed their findings in the fields of speech and language disorders, X-linked mental retardation, gene therapy in the CNS, memory and learning disorders and other fields.
Author | : Eric M. Blalock |
Publisher | : Springer Science & Business Media |
Total Pages | : 356 |
Release | : 2011-06-27 |
Genre | : Science |
ISBN | : 1441987606 |
A Beginner's Guide to Microarrays addresses two audiences - the core facility manager who produces, hybridizes, and scans arrays, and the basic research scientist who will be performing the analysis and interpreting the results. User friendly coverage and detailed protocols are provided for the technical steps and procedures involved in many facets of microarray technology, including: -Cleaning and coating glass slides, -Designing oligonucleotide probes, -Constructing arrays for the detection and quantification of different bacterial species, -Preparing spotting solutions, -Troubleshooting spotting problems, -Setting up and running a core facility, -Normalizing background signal and controlling for systematic variance, -Designing experiments for maximum effect, -Analyzing data with statistical procedures, -Clustering data with machine-learning protocols.
Author | : Hans-Joachim Müller |
Publisher | : Academic Press |
Total Pages | : 229 |
Release | : 2006 |
Genre | : Science |
ISBN | : 0120885433 |
Microarray technology allows us to answer many questions about gene expression and drug-target screening by employing high-throughput screening. This book dedicates itself to microarrays with clear and understandable explanations and an overview of the presently available hardware, biochips and software. Separate chapters cover the different requirements for DNA and protein chips as well as spotters and scanners.
Author | : Jang B. Rampal |
Publisher | : Springer Science & Business Media |
Total Pages | : 927 |
Release | : 2008-02-03 |
Genre | : Science |
ISBN | : 1597453048 |
This second part in the two-volume work Microarrays details applications and data analysis. It includes insight into non-mammalian vertebrate systems, processes and protocols for high quality glass-based microarrays. Coverage includes applications in DNA, peptide, antibody and carbohydrate microarraying, oligonucleotide microarrays generated from hydrolysis PCR probe sequences, microarray platforms in clinical practice, and screening of cDNA libraries on glass slide microarrays. Authors in this volume also discuss protocols for predicting DNA duplex stability on oligonucleotide arrays and integrated analysis of microarray results.