Achieving zero hunger and food security is a top priority in the United Nations Development Goals (UNDGs). In an era characterized by high population growth and increasing pressure on agricultural systems, efficiency in the use of natural resources has become central to sustainable agricultural practices. Fundamentally speaking, eco-efficiency is about maximizing agricultural outputs, in terms of quantity and quality, using less land, water, nutrients, energy, labor, or capital. The concept of eco-efficiency involves both the ecological and economic aspects of sustainable agriculture. It is therefore essential to understand the interaction of ecosystem constituents within the extensive agricultural landscape, as well as farmers’ economic needs. This book examines the latest eco-efficient practices used in agro-systems. Drawing upon research and examples from around the world, it offers an up-to-date overview, together with insights into directly applicable approaches for poly-cropping systems and landscape-scale management to improve the stability of agricultural production systems, helping achieve food security. The book will be of interest to educators, researchers, climate change scientists, capacity builders and policymakers alike. It can also be used as additional reading material for undergraduate and graduate courses on agriculture, forestry, soil science, and the environmental sciences.