Methods In Redox Signaling
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| Author | : Ufuk Çakatay |
| Publisher | : Springer Nature |
| Total Pages | : 447 |
| Release | : 2021-12-02 |
| Genre | : Medical |
| ISBN | : 3030849651 |
This book aims to present the age-related alterations in redox signaling networks and their diagnostic biomarkers in aging cells using multidisciplinary approach. Establishing sensitive and specific biomarkers of dynamic redox homeostasis is crucially important in the development of effective antiaging and senolytic interventions. Recent years have seen tremendous advances in the understanding of redox signaling events which highlight the process of aging and age-related pathologies. A major challenge in biological aging research is developing reliable biomarkers to determine the consequences of disrupted redox signaling networks long before the clinical diagnosis of age-related diseases is made. Therefore, we have chosen to concentrate on aging-induced aberrant redox signaling networks, their biomarkers, and pathological consequences in this book. Although oxidation is a natural metabolic process, the imbalance in the level of oxidants and antioxidants causes oxidative stress and eventually leads to inflammatory conditions, diabetes, neurodegenerative diseases, and cancer. Novel redox-sensitive biomarkers for the evaluation of aging-induced proteinopathies such as amyloid ß and tau proteins in Alzheimer's disease, α-synuclein in Parkinson's disease, and islet amyloid polypeptides in type 2 diabetes mellitus recently drew the attention of researchers. Inside this textbook, readers will find comprehensive perspectives on the association between redox homeostasis and the aging process both at the molecular and clinical levels. Due to the inherent relationship between impaired metabolic activities and oxidative stress, the temporal interaction between intermediary metabolism and disturbed redox status can lead to greater susceptibility to aging-induced diseases and disorders, such as cardiovascular diseases, hypertension, and diabetes. This knowledge could be a key to continued research toward improving medication regimens such as in cancer and cardiovascular therapies, and procedural outcomes for patients. This book brings together current research evidence and knowledge on redox signaling and biomarkers in aging in chapters written by leading global experts in this rapidly evolving field. We hope that this textbook is of interest to a wide group of researchers, advanced students, scientifically curious non-specialist readers and clinicians alike.
| Author | : Avihai Danon |
| Publisher | : World Scientific |
| Total Pages | : 441 |
| Release | : 2003-07-30 |
| Genre | : Science |
| ISBN | : 1783261153 |
Redox regulation, like phosphorylation, is a covalent regulatory system that controls many of the normal cellular functions of all living cells and organisms. In addition, it controls how cells respond to stress involving oxidants and free radicals, which underlie many degenerative diseases. This area is undergoing a transition from general knowledge to specific description of the components and mechanisms involved.This invaluable book provides a timely basic description of a field whose relevance to cell biology and degenerative diseases is of the utmost importance. It describes the state of the art, lays the foundations for understanding the reactions involved, and presents the prospects for future developments. It can serve as a basic text for any undergraduate or graduate course that deals with redox regulation, oxidative stress and free radicals under normal and pathological conditions in bacterial, plant and animal cells.
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 389 |
| Release | : 2010-08-19 |
| Genre | : Science |
| ISBN | : 0123810043 |
This volume, along with its companion (volume 474), presents methods and protocols dealing with thiol oxidation-reduction reactions and their implications as they relate to cell signaling. The critically acclaimed laboratory standard for 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Over 450 volumes have been published to date, and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences. - Along with companion volume, provides a full overview of techniques necessary to the study of thiol redox in relation to cell signaling - Gathers tried and tested techniques from global labs, offering both new and tried-and-true methods - Relevant background and reference information given for procedures can be used as a guide to developing protocols in a number of disciplines
| Author | : Claus Jacob |
| Publisher | : John Wiley & Sons |
| Total Pages | : 514 |
| Release | : 2009-05-06 |
| Genre | : Science |
| ISBN | : 3527627596 |
This first entry-level guide to the multifaceted field takes readers one step further than existing textbooks. In an easily accessible manner, the authors integrate the biochemistry, cell biology and medical implications of intracellular redox processes, demonstrating that complex science can be presented in a clear and almost entertaining way. Perfect for students and junior researchers, this is an equally valuable addition to courses in biochemistry, molecular biology, cell biology, and human physiology.
| Author | : Ursula Jakob |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 488 |
| Release | : 2013-03-15 |
| Genre | : Science |
| ISBN | : 9400757875 |
Many physiological conditions such as host defense or aging and pathological conditions such as neurodegenerative diseases, and diabetes are associated with the accumulation of high levels of reactive oxygen species and reactive nitrogen species. This generates a condition called oxidative stress. Low levels of reactive oxygen species, however, which are continuously produced during aerobic metabolism, function as important signaling molecules, setting the metabolic pace of cells and regulating processes ranging from gene expression to apoptosis. For this book we would like to recruit the experts in the field of redox chemistry, bioinformatics and proteomics, redox signaling and oxidative stress biology to discuss how organisms achieve the appropriate redox balance, the mechanisms that lead to oxidative stress conditions and the physiological consequences that contribute to aging and disease.
| Author | : Yong-Xiao Wang |
| Publisher | : Springer |
| Total Pages | : 429 |
| Release | : 2017-10-18 |
| Genre | : Medical |
| ISBN | : 3319632450 |
The main goal of this book is to form a high-quality platform in which well-known and emerging pioneering basic, translational and clinical scientists can present their latest, exciting findings in the studies of redox signaling in the pulmonary vasculature. Content from outstanding investigators with unique expertise and skills of molecular and cell biology, biochemistry, physiology, pharmacology, biophysics, biotechnology and medicine will update our current out-of-date concepts with new knowledge. Rapidly increasing scientific studies have gathered a large volume of novel and important information on redox signaling in healthy and diseased pulmonary vasculature. This volume covers the need for a cohesive book to display state-of-the-art advances in the field. The second major aim of this book is to help direct future research. Redox signaling is a major molecular process involved in almost every physiologic cellular response in the pulmonary vasculature including energy metabolism, host defense, gene expression, contraction, proliferation, and migration. Aberrancy in this important signaling pathway leads to a critical role in the development of nearly all pulmonary diseases, such as pulmonary hypertension, cor pulmonale, pulmonary edema, and vasculitis, among others.
| Author | : |
| Publisher | : Elsevier |
| Total Pages | : 184 |
| Release | : 2024-08-01 |
| Genre | : Science |
| ISBN | : 0443294453 |
Advances in Cancer Research, Volume 162 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the ACR series - Updated release includes the latest information on the Advances in Cancer Research
| Author | : Ruma Banerjee |
| Publisher | : John Wiley & Sons |
| Total Pages | : 350 |
| Release | : 2007-12-04 |
| Genre | : Science |
| ISBN | : 9780470177327 |
This is the premier, single-source reference on redox biochemistry, a rapidly emerging field. This reference presents the basic principles and includes detailed chapters focusing on various aspects of five primary areas of redox biochemistry: antioxidant molecules and redox cofactors; antioxidant enzymes; redox regulation of physiological processes; pathological processes related to redox; and specialized methods. This is a go-to resource for professionals in pharmaceuticals, medicine, immunology, nutrition, and environmental fields and an excellent text for upper-level students.
| Author | : Gabor Csanyi |
| Publisher | : Frontiers Media SA |
| Total Pages | : 154 |
| Release | : 2019-07-10 |
| Genre | : |
| ISBN | : 2889458881 |
During the last two decades, our view of the role of reactive oxygen species (ROS) in inflammatory processes has changed dramatically. ROS that are constantly produced at lower levels by living cells metabolizing oxygen contribute to normal cellular function and tissue homeostasis. ROS are produced at higher levels in inflammation and regulate the inflammatory response in specific ways. The role of ROS in inflammation is complex and primarily determined by their relative amount, chemical properties, reactivity, subcellular localization and molecular environment, specificity for their biological targets, and availability and mechanisms of antioxidant defense systems. This eBook comprises twelve reviews and original articles that provide new findings on the role of ROS in the regulation of inflammatory processes, highlight emerging topics in redox signaling, describe new ROS detection techniques and discuss alternative therapeutic strategies to treat inflammatory disorders. The editorial that precedes the published articles briefly summarizes the main findings of each research paper. We hope that this collection of research articles contribute to a better understanding of ROS in inflammation.
| Author | : Shailendra Pratap Singh |
| Publisher | : CRC Press |
| Total Pages | : 252 |
| Release | : 2024-06-14 |
| Genre | : Science |
| ISBN | : 1040029086 |
This laboratory reference compiles the essential protocols used in cyanobacterial research. Cyanobacteria is a model system for biofuel production and sequestration of carbon dioxide to tackle global climate change due to increasing levels of greenhouse gases. Topics range from identification and growth parameters to biomolecule estimation and isolation. It also covers genome analysis and bioengineering of cyanobacteria for novel products. Key Features: Provides step-by-step procedures and troubleshooting tips Covers identification, growth parameters and pigment estimation methodologies Describes isolation, characterization and purification of microcystin, phycobiliproteins and scytonemin from cyanobacteria Discusses genomics, proteomics and bioengineering of cyanobacteria from novel products Explains sample preparation and visualization protocol for electron microscopy-based analysis of cyanobacteria This collection is useful to students and researchers in life sciences. It is also meant for industry experts who are involved in the production of biofuels, biofertilizers, other value-added products, and carbon sequestration using cyanobacteria.
