Free Fatty Acid Receptors

Free Fatty Acid Receptors
Author: Graeme Milligan
Publisher: Springer
Total Pages: 258
Release: 2017-02-08
Genre: Medical
ISBN: 3319506935

This book highlights the important role free fatty acids (FFA) play as potential drug targets. While FFA have long been considered byproducts of cell metabolism, they are now recognized as ligands that regulate cell and tissue function via G-protein-coupled receptors. At least three receptors have been identified for which FFA appear to be the endogenous ligands.

Skin Barrier Function

Skin Barrier Function
Author: T. Agner
Publisher: Karger Medical and Scientific Publishers
Total Pages: 172
Release: 2016-02-04
Genre: Medical
ISBN: 3318055867

Although a very fragile structure, the skin barrier is probably one of the most important organs of the body. Inward/out it is responsible for body integrity and outward/in for keeping microbes, chemicals, and allergens from penetrating the skin. Since the role of barrier integrity in atopic dermatitis and the relationship to filaggrin mutations was discovered a decade ago, research focus has been on the skin barrier, and numerous new publications have become available. This book is an interdisciplinary update offering a wide range of information on the subject. It covers new basic research on skin markers, including results on filaggrin and on methods for the assessment of the barrier function. Biological variation and aspects of skin barrier function restoration are discussed as well. Further sections are dedicated to clinical implications of skin barrier integrity, factors influencing the penetration of the skin, influence of wet work, and guidance for prevention and saving the barrier. Distinguished researchers have contributed to this book, providing a comprehensive and thorough overview of the skin barrier function. Researchers in the field, dermatologists, occupational physicians, and related industry will find this publication an essential source of information.

Finding a Path to Safety in Food Allergy

Finding a Path to Safety in Food Allergy
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
Total Pages: 575
Release: 2017-05-27
Genre: Medical
ISBN: 0309450314

Over the past 20 years, public concerns have grown in response to the apparent rising prevalence of food allergy and related atopic conditions, such as eczema. Although evidence on the true prevalence of food allergy is complicated by insufficient or inconsistent data and studies with variable methodologies, many health care experts who care for patients agree that a real increase in food allergy has occurred and that it is unlikely to be due simply to an increase in awareness and better tools for diagnosis. Many stakeholders are concerned about these increases, including the general public, policy makers, regulatory agencies, the food industry, scientists, clinicians, and especially families of children and young people suffering from food allergy. At the present time, however, despite a mounting body of data on the prevalence, health consequences, and associated costs of food allergy, this chronic disease has not garnered the level of societal attention that it warrants. Moreover, for patients and families at risk, recommendations and guidelines have not been clear about preventing exposure or the onset of reactions or for managing this disease. Finding a Path to Safety in Food Allergy examines critical issues related to food allergy, including the prevalence and severity of food allergy and its impact on affected individuals, families, and communities; and current understanding of food allergy as a disease, and in diagnostics, treatments, prevention, and public policy. This report seeks to: clarify the nature of the disease, its causes, and its current management; highlight gaps in knowledge; encourage the implementation of management tools at many levels and among many stakeholders; and delineate a roadmap to safety for those who have, or are at risk of developing, food allergy, as well as for others in society who are responsible for public health.

Skin Barrier

Skin Barrier
Author: Peter M. Elias
Publisher: CRC Press
Total Pages: 634
Release: 2005-09-22
Genre: Medical
ISBN: 084936129X

A must-have reference for any researcher or scientist interested in cutaneous protective mechanisms, this guide provides expertly researched chapters on every aspect of stratum corneum structure, function, and development, as well as detailed sections on barrier-repair strategies and the role of barrier function in diseases such as atopic dermatiti

Lipids and Skin Health

Lipids and Skin Health
Author: Apostolos Pappas
Publisher: Springer
Total Pages: 348
Release: 2014-12-15
Genre: Science
ISBN: 3319099434

Lipids and Skin Health is the first effort to summarize and review the studies, ideas, and research that link lipid metabolism to the largest organ of our body, the skin. The book covers the fundamental biology of the skin, and the major involvement of the transcriptional factors that govern lipid synthesis and the bioactive lipids in this intriguing organ. All layers of skin are presented, as well as their relevant lipids from the epidermis to dermis and even to the hypodermis. The important and unique-to-skin biological pathways are laid out, with a special focus on the various models that demonstrate the essential role of lipid synthesis in skin pathophysiology. The use of lipids in the cosmetic industry is emphasized, and last but not least the involvement of lipids in the clinical setting is also discussed. This book will appeal to healthcare professionals, researchers and dermatology professionals, and will help them to brainstorm new products and opportunities that will target the emerging importance of lipid metabolism in skin for acne, aging, and healthy skin. Apostolos Pappas, Ph.D., is a professional member of the Institute of Food Technology. He started his professional career as a research biochemist in the Skin Research Center of Johnson & Johnson and later served as a group leader at Munich Biotech, where he worked on cancer research. Thereafter he returned to Johnson & Johnson, where he is currently a Research Manager and Fellow focusing on lipid metabolism research. He has authored numerous scientific publications, patent applications, and books.

Tacrolimus Ointment

Tacrolimus Ointment
Author: T. Ruzicka
Publisher: Springer Science & Business Media
Total Pages: 285
Release: 2013-04-17
Genre: Medical
ISBN: 3662102099

Therapeutic breakthroughs in medicine are usually accompanied by a wealth of data. Often they result in a change of disease treatment paradigms. Tacrolimus ointment is the first in the new class of steroid-free Topical Immunomodulators (TIMs), and as such represents the first true breakthrough since the introduction of topical steroids more than 50 years ago for the treatment of T-cell mediated inflammatory skin diseases such as atopic dermatitis. This book gives an easy-to-read overview of the discovery and the development of Tacrolimus ointment for the treatment of atopic dermatitis. Summarising the largest clinical trial program ever conducted in dermatology for a new treatment with more than 13000 patients, it offers a detailed insight into the efficacy and safety profile of Tacrolimus ointment. Based on this large body of data and extensive personal experience, the authors offer practical and hands-on guidance for the physician as to when and how to use Tacrolimus ointment in daily practice.

Handbook of Atopic Eczema

Handbook of Atopic Eczema
Author: Thomas Ruzicka
Publisher: Springer Science & Business Media
Total Pages: 491
Release: 2013-03-09
Genre: Medical
ISBN: 3662026716

State-of-the-art review on atopic eczema, one of the most common skin diseases today. This multi-authored handbook covers all aspects relevant for physicians from various disciplines.

Science and Technology Against Microbial Pathogens

Science and Technology Against Microbial Pathogens
Author: A. M‚ndez-Vilas
Publisher: World Scientific
Total Pages: 447
Release: 2011
Genre: Science
ISBN: 9814354856

The aim of this book is to disseminate the most recent research in science and technology against microbial pathogens presented at the first edition of the ICAR Conference Series (ICAR2010) held in Valladolid, Spain, in November 2010. This volume is a compilation of 86 chapters written by active researchers that offer information and experiences and afford critical insights into anti-microbe strategies in a general context marked by the threat posed by the increasing antimicrobial resistance of pathogenic microorganisms. "Anti" is here taken in a wide sense as "against cell cycle, adhesion, or communication," and when harmful for the human health (infectious diseases, chemotherapy etc.) and industry or economy (food, agriculture, water systems etc.) The book examines this interesting subject area from antimicrobial resistance (superbugs, emerging and re-emerging pathogens etc.), to the use of natural products or microbes against microbial pathogens, not forgetting antimicrobial chemistry, physics and material science. Readers will find in a single volume, up-to-date information of the current knowledge in antimicrobial research. The book is recommended for researchers from a broad range of academic disciplines that are contributing in the battle against harmful microorganisms, not only those more traditionally involved in this research area (microbiologists, biochemists, geneticists, clinicians etc.), but also experimental and theoretical/computational chemists, physicists or engineers.