Mechanistic Insights Of Drug Resistance In Staphylococcus Aureus With Special Reference To Newer Antibiotics
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| Author | : Jun Lin |
| Publisher | : Frontiers Media SA |
| Total Pages | : 226 |
| Release | : 2015-06-01 |
| Genre | : Antibiotics |
| ISBN | : 2889195260 |
Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse.gov/sites/default/files/docs/carb_national_strategy.pdf). Understanding the mechanisms by which bacteria successfully defend themselves against the antibiotic assault represent the main theme of this eBook published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy. The articles in the eBook update the reader on various aspects and mechanisms of antibiotic resistance. A better understanding of these mechanisms should facilitate the development of means to potentiate the efficacy and increase the lifespan of antibiotics while minimizing the emergence of antibiotic resistance among pathogens.
| Author | : Thomas J. Dougherty |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 1119 |
| Release | : 2011-12-18 |
| Genre | : Medical |
| ISBN | : 1461414008 |
This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.
| Author | : Vincent A. Fischetti |
| Publisher | : |
| Total Pages | : 760 |
| Release | : 2000 |
| Genre | : Bacterial vaccines |
| ISBN | : |
This book is the only single volume to deal with all aspects of gram–positive pathogens. It addresses the mechanisms of gram–positive bacterial pathogenicity, including the current knowledge on gram–positive structure and mechanisms of antibiotic resistance. Emphasizing streptococci, staphylococci, listeria, and spore–forming pathogens, Gram–Positive Pathogens includes chapters written by many of the leading researchers in these areas. The chapters systematically dissect these organisms biologically, genetically, and immunologically in an attempt to understand the strategies used by these bacteria to cause human disease.
| Author | : Shymaa Enany |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 236 |
| Release | : 2017-03-08 |
| Genre | : Science |
| ISBN | : 9535129813 |
Staphylococcus was first recognized as a human pathogen in 1880 and was named for its grape cluster-like appearance. In 1884, Staphylococcus aureus was identified and named for its vibrant golden color, which was later found to be the result of golden toxin production. Here, experts examine in-depth patterns of S. aureus colonization and exposures in humans, mammals, and birds that have led to the development of various clinical diseases. The mode of transmission of S. aureus and different methods for its detection in different samples are defined. Conventional antibiotic options to treat this aggressive, multifaceted, and readily adaptable pathogen are becoming limited. Alternative, novel chemotherapeutics to target S. aureus are discussed in the pages within, including herbal medicines, bee products, and modes of delivery.
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 102 |
| Release | : 2006-01-03 |
| Genre | : Medical |
| ISBN | : 0309180686 |
Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.
| Author | : World Health Organization |
| Publisher | : |
| Total Pages | : 232 |
| Release | : 2014 |
| Genre | : Medical |
| ISBN | : 9789241564748 |
Summary report published as technical document with reference number: WHO/HSE/PED/AIP/2014.2.
| Author | : |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 254 |
| Release | : 2021-12-08 |
| Genre | : Medical |
| ISBN | : 1839627425 |
Staphylococcus aureus is a coccus, gram-positive, non-spore forming, and non-motile bacterium. Its commensal and opportunistic capabilities make it able to colonize different sites of animals and humans. Resistance to antibiotics has resulted in development of new strains and new types within strains. Types of methicillin-resistant S. aureus (MRSA) include hospital-acquired MRSA (HA-MRSA), community-acquired MRSA (CA-MRSA), and livestock-acquired MRSA (LA-MRSA). There are also new strains like vancomycin-resistant S. aureus (VRSA) and vancomycin-intermediate S. aureus (VISA). Expansion in resistance is expected to give rise to newer strains resistant to antibiotics such as macrolide (erm gene), tetracycline (tet genes), mupirocin (mupR), and fusidic acid (fusD). Alternative approaches like nanoparticles, bacteriophages, phytochemicals, and more are required to tackle this pathogen. This book contains information on epidemiology, resistance mechanisms, and alternative ways to curtail S. aureus infection, as well as future research opportunities.
| Author | : W. Scott Champney |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 274 |
| Release | : 2008-01-15 |
| Genre | : Medical |
| ISBN | : 1588299155 |
This book examines specific techniques which can be used to explore new drug targets and the effectiveness of new antibiotics. By testing new antimicrobial agents and modified existing drugs, the most vulnerable cell processes, such as cell wall and membrane synthesis, DNA replication, RNA transcription and protein synthesis, can be better exploited. This in-depth volume, however, delves even deeper by identifying additional novel cellular targets for these new therapies. The book will provide laboratory investigators with the vital tools they need to test the antimicrobial potential of products and to curb the rise of so many infectious diseases.
| Author | : Naga Raju Maddela |
| Publisher | : Springer Nature |
| Total Pages | : 455 |
| Release | : 2021-10-23 |
| Genre | : Technology & Engineering |
| ISBN | : 303080108X |
This contributed volume compiles the latest improvements in the field of biotechnology. It focuses on topics that comprises industrial, environment, agricultural and medical related issues to technology and biological studies and exhibits the correlation between the biological world and the dependence of humans on it. The book is organized into five parts covering the role of biotechnology in industrial products, environmental remediation, agriculture and pharmacological agents. Ranging from micro-scale studies to macro, it covers a huge domain of agricultural biotechnology and focuses on important commercial crops (e.g. cacao and coffee), arbuscular mycorrhizal fungi, flow and distribution of phosphorus in agricultural soils in the Latin American region. Overall, the book portrays the importance of modern biotechnology and its role in solving the problems in modern day life. The book is a ready reference for practicing students, researchers of environmental engineering, chemical engineering, agricultural engineering, and other allied fields likewise.
| Author | : Busi Siddhardha |
| Publisher | : Springer Nature |
| Total Pages | : 685 |
| Release | : 2020-03-28 |
| Genre | : Science |
| ISBN | : 9811516952 |
This book provides essential insights into microbial pathogenesis, host-pathogen interactions, and the anti-microbial drug resistance of various human pathogens on the basis of various model organisms. The initial sections of the book introduce readers to the mechanisms of microbial pathogenesis, host-pathogen interactions, anti-microbial drug resistance, and the dynamics of biofilm formation. Due to the emergence of various microbial resistant strains, it is especially important to understand the prognosis for microbial infections, disease progression profiles, and mechanisms of resistance to antibiotic therapy in order to develop novel therapeutic strategies. In turn, the second part of the book presents a comparative analysis of various animal models to help readers understand microbial pathogenesis, host-pathogen interactions, anti-microbial drug discovery, anti-biofilm therapeutics, and treatment regimes. Given its scope, the book represents a valuable asset for microbiologists, biotechnologists, medical professionals, drug development researchers, and pharmacologists alike.
