Evaluating Evidence of Mechanisms in Medicine

Evaluating Evidence of Mechanisms in Medicine
Author: Veli-Pekka Parkkinen
Publisher: Springer
Total Pages: 131
Release: 2018-07-13
Genre: Medical
ISBN: 3319946102

This book is open access under a CC BY license. This book is the first to develop explicit methods for evaluating evidence of mechanisms in the field of medicine. It explains why it can be important to make this evidence explicit, and describes how to take such evidence into account in the evidence appraisal process. In addition, it develops procedures for seeking evidence of mechanisms, for evaluating evidence of mechanisms, and for combining this evaluation with evidence of association in order to yield an overall assessment of effectiveness. Evidence-based medicine seeks to achieve improved health outcomes by making evidence explicit and by developing explicit methods for evaluating it. To date, evidence-based medicine has largely focused on evidence of association produced by clinical studies. As such, it has tended to overlook evidence of pathophysiological mechanisms and evidence of the mechanisms of action of interventions. The book offers a useful guide for all those whose work involves evaluating evidence in the health sciences, including those who need to determine the effectiveness of health interventions and those who need to ascertain the effects of environmental exposures.

In Search of Mechanisms

In Search of Mechanisms
Author: Carl F. Craver
Publisher: University of Chicago Press
Total Pages: 251
Release: 2013-10-03
Genre: Science
ISBN: 022603982X

Neuroscientists investigate the mechanisms of spatial memory. Molecular biologists study the mechanisms of protein synthesis and the myriad mechanisms of gene regulation. Ecologists study nutrient cycling mechanisms and their devastating imbalances in estuaries such as the Chesapeake Bay. In fact, much of biology and its history involves biologists constructing, evaluating, and revising their understanding of mechanisms. With In Search of Mechanisms, Carl F. Craver and Lindley Darden offer both a descriptive and an instructional account of how biologists discover mechanisms. Drawing on examples from across the life sciences and through the centuries, Craver and Darden compile an impressive toolbox of strategies that biologists have used and will use again to reveal the mechanisms that produce, underlie, or maintain the phenomena characteristic of living things. They discuss the questions that figure in the search for mechanisms, characterizing the experimental, observational, and conceptual considerations used to answer them, all the while providing examples from the history of biology to highlight the kinds of evidence and reasoning strategies employed to assess mechanisms. At a deeper level, Craver and Darden pose a systematic view of what biology is, of how biology makes progress, of how biological discoveries are and might be made, and of why knowledge of biological mechanisms is important for the future of the human species.

Compliant Mechanisms

Compliant Mechanisms
Author: Larry L. Howell
Publisher: John Wiley & Sons
Total Pages: 484
Release: 2001-08-03
Genre: Technology & Engineering
ISBN: 9780471384786

"Compliant Mechanisms" beschreibt eine besonders exakte, flexible und zuverlässige Entwurfsmethode im Maschinenbau, vorgestellt von einem international anerkannten Experten. Einem allgemeinen Überblick folgt die Erläuterung fortgeschrittener, moderner, zum Teil hochspezialisierter Anwendungen.

Horten's Miraculous Mechanisms

Horten's Miraculous Mechanisms
Author: Lissa Evans
Publisher: Union Square & Co.
Total Pages: 143
Release: 2012-04-03
Genre: Juvenile Fiction
ISBN: 1402798458

Enter a wonderful world filled with real magic, mystery … and danger. As if being small for his age and also having S. Horten as his name isnt bad enough, now 10-year-old Stuart is forced to move far away from all his friends.But on his very first day in his new home, Stuarts swept up in an extraordinary adventure: the quest to find his great-uncle Tony--a famous magician who literally disappeared off the face of the earth--and Tonys marvelous, long-lost workshop. Along the way, Stuart reluctantly accepts help from the annoying triplets next door… and encounters trouble from another magician whos also desperate to get hold of Tonys treasures. A quirky, smart, charming page-turner, Hortens Miraculous Mechanisms will enchant young readers--as well as teachers, librarians, and parents. Long-listed for the Carnegie Medal (2012) and the Guardian Childrens Fiction Prize (2011)

A Brief Illustrated History of Machines and Mechanisms

A Brief Illustrated History of Machines and Mechanisms
Author: Emilio Bautista Paz
Publisher: Springer Science & Business Media
Total Pages: 228
Release: 2010-08-02
Genre: Technology & Engineering
ISBN: 904812512X

Machines have always gone hand-in-hand with the cultural development of m- kind throughout time. A book on the history of machines is nothing more than a specific way of bringing light to human events as a whole in order to highlight some significant milestones in the progress of knowledge by a complementary persp- tive into a general historical overview. This book is the result of common efforts and interests by several scholars, teachers, and students on subjects that are connected with the theory of machines and mechanisms. In fact, in this book there is a certain teaching aim in addition to a general historical view that is more addressed to the achievements by “homo faber” than to those by “homo sapiens”, since the proposed history survey has been developed with an engineering approach. The brevity of the text added to the fact that the authors are probably not com- tent to tackle historical studies with the necessary rigor, means the content of the book is inevitably incomplete, but it nevertheless attempts to fulfil three basic aims: First, it is hoped that this book may provide a stimulus to promote interest in the study of technical history within a mechanical engineering context. Few are the co- tries where anything significant is done in this area, which means there is a general lack of knowledge of this common cultural heritage.

Ingenious Mechanisms for Designers and Inventors ...

Ingenious Mechanisms for Designers and Inventors ...
Author: Franklin D. Jones
Publisher: Industrial Press Inc.
Total Pages: 550
Release: 1930
Genre: Technology & Engineering
ISBN: 9780831110307

''Many contributors have submitted for publication in Machinery's columns most of the mechanical movements described.''.

Mechanisms

Mechanisms
Author: Matthew G. Kirschenbaum
Publisher: MIT Press
Total Pages: 315
Release: 2008
Genre: Computer storage devices
ISBN: 0262113112

A new "textual studies" and archival approach to the investigation of works of new media and electronic literature that applies techniques of computer forensics to conduct media-specific readings of William Gibson's electronic poem "Agrippa," Michael Joyce's Afternoon, and the interactive game Mystery House.

Handbook of Compliant Mechanisms

Handbook of Compliant Mechanisms
Author: Larry L. Howell
Publisher: John Wiley & Sons
Total Pages: 356
Release: 2013-04-01
Genre: Technology & Engineering
ISBN: 1119953456

A fully illustrated reference book giving an easy-to-understand introduction to compliant mechanisms A broad compilation of compliant mechanisms to give inspiration and guidance to those interested in using compliant mechanisms in their designs, the Handbook of Compliant Mechanisms includes graphics and descriptions of many compliant mechanisms. It comprises an extensive categorization of devices that can be used to help readers identify compliant mechanisms related to their application. It also provides chapters on the basic background in compliant mechanisms, the categories of compliant mechanisms, and an example of how the Compendium can be used to facilitate compliant mechanism design. Fully illustrated throughout to be easily understood and accessible at introductory levels Covers all aspects pertaining to classification, elements, mechanisms and applications of compliant mechanisms Summarizes a vast body of knowledge in easily understood diagrams and explanations Helps readers appreciate the advantages that compliant mechanisms have to offer Practical approach is ideal for potential practitioners who would like to realize designs with compliant mechanisms, members and elements Breadth of topics covered also makes the book a useful reference for more advanced readers Intended as an introduction to the area, the Handbook avoids technical jargon to assist non engineers involved in product design, inventors and engineers in finding clever solutions to problems of design and function.

Mechanisms in Ancient Chinese Books with Illustrations

Mechanisms in Ancient Chinese Books with Illustrations
Author: Kuo-Hung Hsiao
Publisher: Springer Science & Business Media
Total Pages: 310
Release: 2013-12-12
Genre: Technology & Engineering
ISBN: 3319020099

This book presents a unique approach for studying mechanisms and machines with drawings that were depicted unclearly in ancient Chinese books. The historical, cultural and technical backgrounds of the mechanisms are explained, and various mechanisms described and illustrated in ancient books are introduced. By utilizing the idea for the conceptual design of modern mechanisms, all feasible designs of ancient mechanisms with uncertain members and joints that meet the technical standards of the subjects’ time periods are synthesized systematically. Ancient Chinese crossbows (the original crossbow and repeating crossbows), textile mechanisms (silk-reeling mechanism, spinning mechanisms, and looms), and many other artisan's tool mechanisms are used as illustrated examples. Such an approach provides a logical method for the reconstruction designs of ancient mechanisms with uncertain structures. It also provides an innovative direction for researchers to further identify the original structures of mechanisms and machines with drawings in ancient literature. This book can be used as a textbook and/or supplemental reading material for courses related to history of ancient (Chinese) machinery and creative mechanism design for senior and graduate students.

Making Things Move DIY Mechanisms for Inventors, Hobbyists, and Artists

Making Things Move DIY Mechanisms for Inventors, Hobbyists, and Artists
Author: Dustyn Roberts
Publisher: McGraw Hill Professional
Total Pages: 369
Release: 2010-12-06
Genre: Technology & Engineering
ISBN: 0071741682

Get Your Move On! In Making Things Move: DIY Mechanisms for Inventors, Hobbyists, and Artists, you'll learn how to successfully build moving mechanisms through non-technical explanations, examples, and do-it-yourself projects--from kinetic art installations to creative toys to energy-harvesting devices. Photographs, illustrations, screen shots, and images of 3D models are included for each project. This unique resource emphasizes using off-the-shelf components, readily available materials, and accessible fabrication techniques. Simple projects give you hands-on practice applying the skills covered in each chapter, and more complex projects at the end of the book incorporate topics from multiple chapters. Turn your imaginative ideas into reality with help from this practical, inventive guide. Discover how to: Find and select materials Fasten and join parts Measure force, friction, and torque Understand mechanical and electrical power, work, and energy Create and control motion Work with bearings, couplers, gears, screws, and springs Combine simple machines for work and fun Projects include: Rube Goldberg breakfast machine Mousetrap powered car DIY motor with magnet wire Motor direction and speed control Designing and fabricating spur gears Animated creations in paper An interactive rotating platform Small vertical axis wind turbine SADbot: the seasonally affected drawing robot Make Great Stuff! TAB, an imprint of McGraw-Hill Professional, is a leading publisher of DIY technology books for makers, hackers, and electronics hobbyists.