Mathematical Modelling And Biomechanics Of The Brain
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| Author | : Corina Drapaca |
| Publisher | : Springer Nature |
| Total Pages | : 160 |
| Release | : 2019-09-06 |
| Genre | : Mathematics |
| ISBN | : 1493998102 |
This monograph aims to provide a rigorous yet accessible presentation of some fundamental concepts used in modeling brain mechanics and give a glimpse of the insights and advances that have arisen as a result of the nascent interaction of the mathematical and neurosurgical sciences. It begins with some historical perspective and a brief synopsis of the biomedical/biological manifestations of the clinical conditions/diseases considered. Each chapter proceeds with a discussion of the various mathematical models of the problems considered, starting with the simplest models and proceeding to more complex models where necessary. A detailed list of relevant references is provided at the end of each chapter. With the beginning research student in mind, the chapters have been crafted to be as self-contained as possible while addressing different clinical conditions and diseases. The book is intended as a brief introduction to both theoreticians and experimentalists interested in brain mechanics, with directions and guidance for further reading, for those who wish to pursue particular topics in greater depth. It can also be used as a complementary textbook in a graduate level course for neuroscientists and neuroengineers.
| Author | : Karol Miller |
| Publisher | : Springer |
| Total Pages | : 356 |
| Release | : 2019-08-08 |
| Genre | : Science |
| ISBN | : 3030049965 |
This new edition presents an authoritative account of the current state of brain biomechanics research for engineers, scientists and medical professionals. Since the first edition in 2011, this topic has unquestionably entered into the mainstream of biomechanical research. The book brings together leading scientists in the diverse fields of anatomy, neuroimaging, image-guided neurosurgery, brain injury, solid and fluid mechanics, mathematical modelling and computer simulation to paint an inclusive picture of the rapidly evolving field. Covering topics from brain anatomy and imaging to sophisticated methods of modeling brain injury and neurosurgery (including the most recent applications of biomechanics to treat epilepsy), to the cutting edge methods in analyzing cerebrospinal fluid and blood flow, this book is the comprehensive reference in the field. Experienced researchers as well as students will find this book useful.
| Author | : Jorge Garza Ulloa |
| Publisher | : Academic Press |
| Total Pages | : 664 |
| Release | : 2018-06-16 |
| Genre | : Technology & Engineering |
| ISBN | : 0128125950 |
Applied Biomechatronics Using Mathematical Models provides an appropriate methodology to detect and measure diseases and injuries relating to human kinematics and kinetics. It features mathematical models that, when applied to engineering principles and techniques in the medical field, can be used in assistive devices that work with bodily signals. The use of data in the kinematics and kinetics analysis of the human body, including musculoskeletal kinetics and joints and their relationship to the central nervous system (CNS) is covered, helping users understand how the complex network of symbiotic systems in the skeletal and muscular system work together to allow movement controlled by the CNS. With the use of appropriate electronic sensors at specific areas connected to bio-instruments, we can obtain enough information to create a mathematical model for assistive devices by analyzing the kinematics and kinetics of the human body. The mathematical models developed in this book can provide more effective devices for use in aiding and improving the function of the body in relation to a variety of injuries and diseases. - Focuses on the mathematical modeling of human kinematics and kinetics - Teaches users how to obtain faster results with these mathematical models - Includes a companion website with additional content that presents MATLAB examples
| Author | : Valeria Zazzu |
| Publisher | : Springer |
| Total Pages | : 207 |
| Release | : 2015-11-26 |
| Genre | : Mathematics |
| ISBN | : 3319234978 |
This book presents an exciting collection of contributions based on the workshop “Bringing Maths to Life” held October 27-29, 2014 in Naples, Italy. The state-of-the art research in biology and the statistical and analytical challenges facing huge masses of data collection are treated in this Work. Specific topics explored in depth surround the sessions and special invited sessions of the workshop and include genetic variability via differential expression, molecular dynamics and modeling, complex biological systems viewed from quantitative models, and microscopy images processing, to name several. In depth discussions of the mathematical analysis required to extract insights from complex bodies of biological datasets, to aid development in the field novel algorithms, methods and software tools for genetic variability, molecular dynamics, and complex biological systems are presented in this book. Researchers and graduate students in biology, life science, and mathematics/statistics will find the content useful as it addresses existing challenges in identifying the gaps between mathematical modeling and biological research. The shared solutions will aid and promote further collaboration between life sciences and mathematics.
| Author | : Gerhard A. Holzapfel |
| Publisher | : Springer |
| Total Pages | : 319 |
| Release | : 2016-09-14 |
| Genre | : Technology & Engineering |
| ISBN | : 3319414755 |
The book presents a state-of-the-art overview of biomechanical and mechanobiological modeling and simulation of soft biological tissues. Seven well-known scientists working in that particular field discuss topics such as biomolecules, networks and cells as well as failure, multi-scale, agent-based, bio-chemo-mechanical and finite element models appropriate for computational analysis. Applications include arteries, the heart, vascular stents and valve implants as well as adipose, brain, collagenous and engineered tissues. The mechanics of the whole cell and sub-cellular components as well as the extracellular matrix structure and mechanotransduction are described. In particular, the formation and remodeling of stress fibers, cytoskeletal contractility, cell adhesion and the mechanical regulation of fibroblast migration in healing myocardial infarcts are discussed. The essential ingredients of continuum mechanics are provided. Constitutive models of fiber-reinforced materials with an emphasis on arterial walls and the myocardium are discussed and the important influence of residual stresses on material response emphasized. The mechanics and function of the heart, the brain and adipose tissues are discussed as well. Particular attention is focused on microstructural and multi-scale modeling, finite element implementation and simulation of cells and tissues.
| Author | : Fabrizio Gabbiani |
| Publisher | : Academic Press |
| Total Pages | : 630 |
| Release | : 2017-02-04 |
| Genre | : Mathematics |
| ISBN | : 0128019069 |
Mathematics for Neuroscientists, Second Edition, presents a comprehensive introduction to mathematical and computational methods used in neuroscience to describe and model neural components of the brain from ion channels to single neurons, neural networks and their relation to behavior. The book contains more than 200 figures generated using Matlab code available to the student and scholar. Mathematical concepts are introduced hand in hand with neuroscience, emphasizing the connection between experimental results and theory. - Fully revised material and corrected text - Additional chapters on extracellular potentials, motion detection and neurovascular coupling - Revised selection of exercises with solutions - More than 200 Matlab scripts reproducing the figures as well as a selection of equivalent Python scripts
| Author | : Kozaburo Hayashi |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 278 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 4431669515 |
The combination of readily available computing power and progress in numerical techniques has made nonlinear systems - the kind that only a few years ago were ignored as too complex - open to analysis for the first time. Now realistic models of living systems incorporating the nonlinear variation and anisotropic nature of physical properties can be solved numerically on modern computers to give realistically usable results. This has opened up new and exciting possibilities for the fusing of ideas from physiology and engineering in the burgeoning new field that is biomechanics. Computational Biomechanics presents pioneering work focusing on the areas of orthopedic and circulatory mechanics, using experimental results to confirm or improve the relevant mathematical models and parameters. Together with two companion volumes, Biomechanics: Functional Adaptation and Remodeling and the Data Book on Mechanical Properties of Living Cells, Tissues, and Organs, this monograph will prove invaluable to those working in fields ranging from medical science and clinical medicine to biomedical engineering and applied mechanics.
| Author | : Roustem N. Miftahof |
| Publisher | : Cambridge University Press |
| Total Pages | : 241 |
| Release | : 2010-05-06 |
| Genre | : Technology & Engineering |
| ISBN | : 1139485776 |
Mathematical modelling of physiological systems promises to advance our understanding of complex biological phenomena and pathophysiology of diseases. In this book, the authors adopt a mathematical approach to characterize and explain the functioning of the gastrointestinal system. Using the mathematical foundations of thin shell theory, the authors patiently and comprehensively guide the reader through the fundamental theoretical concepts, via step-by-step derivations and mathematical exercises, from basic theory to complex physiological models. Applications to nonlinear problems related to the biomechanics of abdominal viscera and the theoretical limitations are discussed. Special attention is given to questions of complex geometry of organs, effects of boundary conditions on pellet propulsion, as well as to clinical conditions, e.g. functional dyspepsia, intestinal dysrhythmias and the effect of drugs to treat motility disorders. With end of chapter problems, this book is ideal for bioengineers and applied mathematicians.
| Author | : Lynne E. Bilston |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 288 |
| Release | : 2011-07-23 |
| Genre | : Technology & Engineering |
| ISBN | : 364213890X |
Damage to the central nervous system resulting from pathological mechanical loading can occur as a result of trauma or disease. Such injuries lead to significant disability and mortality. The peripheral nervous system, while also subject to injury from trauma and disease, also transduces physiological loading to give rise to sensation, and mechanotransduction is also thought to play a role in neural development and growth. This book gives a complete and quantitative description of the fundamental mechanical properties of neural tissues, and their responses to both physiological and pathological loading. This book reviews the methods used to characterize the nonlinear viscoelastic properties of central and peripheral neural tissues, and the mathematical and sophisticated computational models used to describe this behaviour. Mechanisms and models of neural injury from both trauma and disease are reviewed from the molecular to macroscopic scale. The book provides a comprehensive picture of the mechanical and biological response of neural tissues to the full spectrum of mechanical loading to which they are exposed. This book provides a comprehensive reference for professionals involved in pre prevention of injury to the nervous system, whether this arises from trauma or disease.
| Author | : Larry A. Taber |
| Publisher | : Springer Nature |
| Total Pages | : 545 |
| Release | : 2020-06-15 |
| Genre | : Technology & Engineering |
| ISBN | : 3030432092 |
This book examines key theoretical tools that are currently used to develop mathematical models as an aid in understanding the biological response of cells and tissues to mechanical stimuli. Problems in growth and remodeling, tissue and organ development, and functional adaptation are all covered. Chapters on tensor analysis and nonlinear elasticity provide the necessary background for understanding the engineering theories that are currently used to solve challenges in mechanobiology. This is an ideal book for biomechanical engineers who work on problems in mechanobiology and tissue engineering.
