Manual Of Biological Markers Of Disease
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| Author | : W.J. van Venrooij |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 711 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 9401116709 |
A comprehensive reference work: This looseleaf work is an authoritative compilation of methods for the detection of autoantibodies (Section A: Methods of Autoantibody Detection); the structure, function, and molecular and biochemical concepts of autoantigens (Section B: Autoantigens); and the clinical significance of measuring autoantibodies in patients with rheumatic, connective tissue and autoimmune diseases (Section C: Clinical Significance of Autoantibodies). This unique work brings together all the molecular and medical information - very difficult to retrieve otherwise - in ONE publication. The Editors and contributors are leading experts in the immunological, molecular biological, and clinical fields. The format of this looseleaf publication allows regular updating of data as well as inclusion of new advances in research on autoimmunity. Until now, the work (Basic work including Supplement 1) included Section A, and the larger part of Section B, both in an attractive and robust ringbinder. Audience: By nature and design of this exciting reference work, it is especially aimed at scientists, including immunologists, pathologists and molecular biologists, and clinical chemists, as well as clinicians specializing in rheumatic diseases and autoimmune disorders, inflammation or clinical immunology. Supplement 2: This supplement primarily contains Section C (Clinical Significance of Autoantibodies). As in the other sections, the contents are presented in a consistently structured manner, beautifully illustrated with photos and schematic figures. Extensive literature references are provided. Also, this supplement includes an addition to Section B (Autoantigens), being chapter B.1.5: The Antigens Defined by Antikeratin Antibodies (AKA).
| Author | : W. J. van Venrooij |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 816 |
| Release | : 1993-06-30 |
| Genre | : Medical |
| ISBN | : 9780792322191 |
A comprehensive reference work: This looseleaf work is an authoritative compilation of methods for the detection of autoantibodies (Section A: Methods of Autoantibody Detection); the structure, function, and molecular and biochemical concepts of autoantigens (Section B: Autoantigens); and the clinical significance of measuring autoantibodies in patients with rheumatic, connective tissue and autoimmune diseases (Section C: Clinical Significance of Autoantibodies). This unique work brings together all the molecular and medical information - very difficult to retrieve otherwise - in ONE publication. The Editors and contributors are leading experts in the immunological, molecular biological, and clinical fields. The format of this looseleaf publication allows regular updating of data as well as inclusion of new advances in research on autoimmunity. Until now, the work (Basic work including Supplement 1) included Section A, and the larger part of Section B, both in an attractive and robust ringbinder. Audience: By nature and design of this exciting reference work, it is especially aimed at scientists, including immunologists, pathologists and molecular biologists, and clinical chemists, as well as clinicians specializing in rheumatic diseases and autoimmune disorders, inflammation or clinical immunology. Supplement 2: This supplement primarily contains Section C (Clinical Significance of Autoantibodies). As in the other sections, the contents are presented in a consistently structured manner, beautifully illustrated with photos and schematic figures. Extensive literature references are provided. Also, this supplement includes an addition to Section B (Autoantigens), being chapter B.1.5: The Antigens Defined by Antikeratin Antibodies (AKA).
| Author | : Institute of Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 128 |
| Release | : 2008-01-08 |
| Genre | : Medical |
| ISBN | : 0309178282 |
Biomarkers, or biological markers, are quantitative measurements that offer researchers and clinicians valuable insight into diagnosis, treatment and prognosis for many disorders and diseases. A major goal in neuroscience medical research is establishing biomarkers for disorders of the nervous system. Given the promising potential and necessity for neuroscience biomarkers, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened a public workshop and released the workshop summary entitled Neuroscience Biomarkers and Biosignatures: Converging Technologies, Emerging Partnerships. The workshop brought together experts from multiple areas to discuss the most promising and practical arenas in neuroscience in which biomarkers will have the greatest impact. The main objective of the workshop was to identify and discuss biomarker targets that are not currently being aggressively pursued but that could have the greatest near-term impact on the rate at which new treatments are brought forward for psychiatric and neurological disorders.
| Author | : Paul A. Schulte |
| Publisher | : Academic Press |
| Total Pages | : 609 |
| Release | : 2012-12-02 |
| Genre | : Medical |
| ISBN | : 0323138578 |
This book will serve as a primer for both laboratory and field scientists who are shaping the emerging field of molecular epidemiology. Molecular epidemiology utilizes the same paradigm as traditional epidemiology but uses biological markers to identify exposure, disease or susceptibility. Schulte and Perera present the epidemiologic methods pertinent to biological markers. The book is also designed to enumerate the considerations necessary for valid field research and provide a resource on the salient and subtle features of biological indicators.
| Author | : Institute of Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 469 |
| Release | : 2004-08-29 |
| Genre | : Social Science |
| ISBN | : 0309091594 |
The U.S. military's concerns about the individual combat service member's ability to avoid performance degradation, in conjunction with the need to maintain both mental and physical capabilities in highly stressful situations, have led to and interest in developing methods by which commanders can monitor the status of the combat service members in the field. This report examines appropriate biological markers, monitoring technologies currently available and in need of development, and appropriate algorithms to interpret the data obtained in order to provide information for command decisions relative to the physiological "readiness" of each combat service member. More specifically, this report also provides responses to questions posed by the military relative to monitoring the metabolic regulation during prolonged, exhaustive efforts, where nutrition/hydration and repair mechanisms may be mismatched to intakes and rest, or where specific metabolic derangements are present.
| Author | : Sanjay Rajagopalan |
| Publisher | : Lippincott Williams & Wilkins |
| Total Pages | : 697 |
| Release | : 2011-12-14 |
| Genre | : Medical |
| ISBN | : 1451154410 |
Knowledge and understanding of vascular disease, particularly atherosclerosis, continue to expand across disciplines, as do diagnostic and therapeutic strategies for treatment of vascular disorders. This manual offers a consistent "how to" approach that places specific emphasis on management. Each chapter provides the reader with a highly practical approach so that he or she comes away with a reasonable amount of familiarity as to be able to manage the patient independently. Since the first edition, a certification in vascular medicine has become available. Some of the key features include: • Practical information such as drug doses, protocols for managing disorders, and algorithms; • Guidance on diagnostic assessment and treatment strategies for the majority of vascular disorders encountered in clinical practice; • Assimilation of information from areas outside cardiology, i.e., vascular surgeons and interventional radiologists, into a reader-friendly format geared toward the average practicing internist or cardiologist.
| Author | : W.J. van Venrooij |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 532 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 9401154449 |
Section A: Methods of Autoantibody Detection This Section provides well structured protocols for autoantibody detection. Step-by-step procedures are accompanied by explanatory notes and comments, clear diagrams, line illustrations and excellent photo illustrations. Extensive literature references lead the way to further background information. The methods presented were validated by more than 40 leading laboratories active in sera analysis, which indicates that these methods have been found to be practically useful and lead to consistent inter-laboratory results: consensus in autoantibody detection. Section B: Autoantigens This Section contains the first compilation of full, detailed information on autoantigens related to important autoimmune diseases. The chapters are all structured according to an easy-reference fixed template structure: specific detection methods, cellular localization, biochemical characteristics, function, cDNA and derived amino acid sequence, gene structure, B- and T-cell epitopes and lists of published monoclonal antibodies. The text is greatly enhanced by many beautiful schematic figures and photo illustrations. As in Section A, extensive literature references are provided. The information for this section was brought together by leading experts in their fields. This Manual is an ideal text and reference book for bench scientists working in the field of autoimmunity, but also for rheumatologists, general (internal medicine) physicians or clinical immunologists caring for patients with autoimmune disorders.
| Author | : |
| Publisher | : Geological Survey (USGS) |
| Total Pages | : 444 |
| Release | : 1999 |
| Genre | : Medical |
| ISBN | : |
| Author | : John C. Hall |
| Publisher | : PMPH-USA |
| Total Pages | : 522 |
| Release | : 2010 |
| Genre | : Medical |
| ISBN | : 1607951029 |
Stop, look and learn with us as we gather information through the mirror called the skin. The skin has much to tell us about where to look for illness, how grave that illness may be, and what strategies for therapy might be most advantageous. The skin is also the organ most easily accessible for obtaining tissue for pathological examination, culture, and examination of debris. These tools will also be discussed and expanded upon. This book classifies the skin conditions from the standpoint of organ involved as well as specific disease. The text makes use of many illustrations and photographs.
| Author | : Jose Luis Garcia-Gimenez |
| Publisher | : Academic Press |
| Total Pages | : 698 |
| Release | : 2015-12-07 |
| Genre | : Science |
| ISBN | : 0128019212 |
Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease. - Focuses on recent progress in several areas of epigenetics, general concepts regarding epigenetics, and the future prospects of this discipline in clinical diagnostics and prognostics - Describes the importance of the quality of samples and clinical associated data, and also the ethical issues for epigenetic diagnostics - Discusses the advances in epigenomics technologies, including next-generation sequencing based tools and applications - Expounds on the utility of epigenetic biomarkers for diagnosis and prognosis of several diseases, highlighting the study of these biomarkers in cancer, cardiovascular and metabolic diseases, infertility, and infectious diseases - Includes a special section that discusses the relevance of biobanks in the maintenance of high quality biosamples and clinical-associated data, and the relevance of the ethical aspects in epigenetic studies
