Local Stereology

Local Stereology
Author: Eva B. Vedel Jensen
Publisher: World Scientific
Total Pages: 272
Release: 1998
Genre: Mathematics
ISBN: 9789810224547

This book provides a unified exposition of local-stereological methods developed within the last 15 years. The object of local stereology is to draw inference about quantitative parameters of spatial structures which can be regarded as neighbourhoods of points, called reference points. The model example is a biological cell which can be regarded as a neighbourhood of its nucleus. In local stereology, information from sections through the reference point is used. Only very weak assumptions are needed for the structure under study. For instance, specific cell shape assumptions are not necessary.In order to reach a broader audience, the book has been written not only for specialists in stereology, integral geometry and geometric measure theory. In particular, Chapter 1 is an elementary introduction to stereology and the book contains about 75 illustrations. The theory of local steroelogy involves, however, advanced mathematical tools, which constitute an important part of the book.Local-stereological methods are now in world-wide use in the microscopical study of biological tissue, and this invaluable book also contains a description of how the local methods are used in practice.

Basic Stereology for Biologists and Neuroscientists

Basic Stereology for Biologists and Neuroscientists
Author: Mark J. West
Publisher:
Total Pages: 0
Release: 2012
Genre: Autonomic nervous system
ISBN: 9781936113606

Stereological techniques allow biologists to create quantitative, three-dimensional descriptions of biological structures from two- dimensional images of tissue viewed under the microscope. For example, they can accurately estimate the size of a particular organelle, the total length of a mass of capillaries, or the number of neurons or synapses in a particular region of the brain. This book provides a practical guide to designing and critically evaluating stereological studies of the nervous system and other tissues. It explains the basic concepts behind design-based stereology and how to get started. Also included are detailed descriptions of how to prepare tissue appropriately, perform pilot studies and decide on the appropriate sampling strategy, and account for phenomena such as tissue shrinkage. Numerous examples of applications of stereological methods that are applicable to studies of the central system and a wide variety of other tissues are explained. The book is therefore essential reading for neurobiologists and cell biologists interested in generating accurate representations of cell and tissue architecture.

Stereology for Statisticians

Stereology for Statisticians
Author: Adrian Baddeley
Publisher: CRC Press
Total Pages: 412
Release: 2004-11-29
Genre: Mathematics
ISBN: 1135438366

Setting out the principles of stereology from a statistical viewpoint, this book focuses on both basic theory and practical implications. The authors discuss ways to effectively communicate statistical issues to clients, draw attention to common methodological errors, and provide references to essential literature. The first full text on design-based stereology opens with a review of classical and modern stereology, followed by a treatment of mathematical foundations and then on to core techniques. The final chapters discuss implementing techniques in practical sampling designs, summarize understanding of the variance of stereological estimators, and describe open problems for further research. The book also details isotropic, vertical or local sampling designs for estimating stereological parameters such as volume, surface area, particle number and spatial distribution. This extensive text offers support to statistical consultants using examples, applications and unique Advice to Consultants sections. It contains numerous literature references, bibliographic notes and nearly 150 illustrations.

Unbiased Stereology

Unbiased Stereology
Author: Peter R. Mouton
Publisher: JHU Press
Total Pages: 195
Release: 2011-07-19
Genre: Science
ISBN: 0801899850

This update to Peter R. Mouton's pioneering work provides bioscientists with the concepts needed in order to apply the principles and practices of unbiased stereology to research involving biological tissues. Mouton starts with a brief explanation of the history and theory of the process before defining the terms, concepts, and tools of unbiased stereological procedures. He compares and contrasts the procedures with less-exacting approaches to quantitative analysis of biological structure using specific examples from biomedical literature. The book incorporates existing best practices with new methodologies, such as the Rare Event Protocol, while simplifying the dense, often difficult literature on the Subject to show the utility and importance of unbiased stereology. This clear, insightful guide goes a step further than other books on this Subject by demonstrating not only how to use unbiased stereology but also how to interpret and present the results. Written by the official U.S. representative to the International Society for Stereology, this is the most complete, up-to-date resource on the science of unbiased stereology. Those new to bioscience research as well as experienced practitioners will find that Mouton's explanations are the perfect companion for stereology courses and workshops.

Unbiased Stereology

Unbiased Stereology
Author: Vyvyan Howard
Publisher: Garland Science
Total Pages: 277
Release: 2004-11-15
Genre: Medical
ISBN: 0203006399

Unbiased Stereology, Second Edition is a practical guide to making unbiased 3-D measurements via the microscope. Only those stereological techniques which have been tried and tested by real application are included. Although this technology is essentially mathematical and statistical, the authors do not immerse the reader in complex analysis, but rather provide simple heuristic explanations and references to the original proof, and illustrate the theory by analogies drawn from everyday experience. To give practical experience in application of the techniques, exercises are provided at the end of each chapter, complete with detailed worked answers.

Stereology for Statisticians

Stereology for Statisticians
Author: Adrian Baddeley
Publisher: CRC Press
Total Pages: 412
Release: 2004-11-29
Genre: Mathematics
ISBN: 0203496817

Setting out the principles of stereology from a statistical viewpoint, this book focuses on both basic theory and practical implications. The authors discuss ways to effectively communicate statistical issues to clients, draw attention to common methodological errors, and provide references to essential literature. The first full text on design-bas

Quantitative Methods in Neuroscience

Quantitative Methods in Neuroscience
Author: Stephen M. Evans
Publisher:
Total Pages: 362
Release: 2004
Genre: Medical
ISBN: 9780198505280

Stereology is a valuable tool for neuroscientists, allowing them to obtain 3-Dimensional information from 2-Dimensional measurements made on appropriately sampled sections (usually obtained from histological sections or MRI/CT/PET scans). This 3-D information is invaluable in correlatingstructural/functional relationships in the pursuit of far greater understanding of the function of the central nervous system. However, in carrying out such measurements, often based on limited data sets, there is a risk of experimenter bias. An important feature of modern design based stereology isto be aware of potential sources of bias and eliminate them during the data collection. With many of the major neuroscience journals now insisting that quantitative data be presented, there is a greater need than ever for neuroscientists to understand the theory and practice behind quantitativemethods, such as those offered by stereology. Quantitative Methods in Neuroscience is a cookbook of stereological methods written especially for neuroscientists. It provides clear and accessible advice about when and when not to use stereology. Throughout the book, the emphasis is on practical guidance, rather than discussions and formulae.Written by leading scientists in the field of stereology, with a Foreword by D.C. Sterio, the book will be a valuable introduction to these methods for neuroscientists, and all those involved in development of new drug programmes.

Stochastic Geometry, Spatial Statistics and Random Fields

Stochastic Geometry, Spatial Statistics and Random Fields
Author: Volker Schmidt
Publisher: Springer
Total Pages: 484
Release: 2014-10-24
Genre: Mathematics
ISBN: 3319100645

This volume is an attempt to provide a graduate level introduction to various aspects of stochastic geometry, spatial statistics and random fields, with special emphasis placed on fundamental classes of models and algorithms as well as on their applications, e.g. in materials science, biology and genetics. This book has a strong focus on simulations and includes extensive codes in Matlab and R which are widely used in the mathematical community. It can be seen as a continuation of the recent volume 2068 of Lecture Notes in Mathematics, where other issues of stochastic geometry, spatial statistics and random fields were considered with a focus on asymptotic methods.