Alexandrianism was among the trends that defined the formation of Roman literature across genres since the early decades of Roman literary history. This volume introduces a collection of original essays that contribute to a developing appreciation of the comedy of Plautus, the leading representative of Roman comedy, as a multi-faceted text that engages in a creative dialogue with various contemporary cultural and literary developments. The studies here, both individually and as parts of a longer, interactive discussion, offer a comprehensive examination of the first complete expression of the intellectual reception of Greek and Hellenistic literature and culture in Rome, and, at the same time, examine Plautus’ correspondence with the popularization of science and medicine, the Romanization of philosophy, and contemporary religious practices. As the first Latin poet whose work survives in extant form, Plautus is also examined here as a major literary figure who significantly influenced the development of Latin literature. This book will appeal to specialist scholars of Roman comedy, but also to graduate students working in the fields of classics and literary history. All long quotations of Greek and Latin are translated.