This Special Publication combines results obtained by interdisciplinary groups from numerous academic institutions working on Paleoproterozoic formations to decipher the origins of the main mineralization resources in the West African Craton (WAC) and their impacts on African economic development. Structural, geophysical, sedimentological, stratigraphical, geochemical, petrophysical and mineralogical analyses have been used to highlight the complexities involved in mineralization emplacement and its origin and evolution within the WAC. Fourteen articles contribute to new knowledge in mineral research. They show that the geodynamic evolution of the WAC is complex from one area to another: it involves subduction, collision and obduction during several deformation phases ranging from Birimian (2.3–2.0 Ga) to Pan-African (650–450 Ma) events. Various modelling techniques, when integrated, help in understanding the mechanisms of mineralization emplacement, some of which are still a matter of debate. The challenge for further studies is mitigation for sustainable development that can be appropriately used to minimize such damage.