Innovations And Implementations Of Computer Aided Drug Discovery Strategies In Rational Drug Design
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| Author | : Sanjeev Kumar Singh |
| Publisher | : Springer Nature |
| Total Pages | : 334 |
| Release | : 2021-02-02 |
| Genre | : Science |
| ISBN | : 9811589364 |
This book presents various computer-aided drug discovery methods for the design and development of ligand and structure-based drug molecules. A wide variety of computational approaches are now being used in various stages of drug discovery and development, as well as in clinical studies. Yet, despite the rapid advances in computer software and hardware, combined with the exponential growth in the available biological information, there are many challenges that still need to be addressed, as this book shows. In turn, it shares valuable insights into receptor-ligand interactions in connection with various biological functions and human diseases. The book discusses a wide range of phylogenetic methods and highlights the applications of Molecular Dynamics Simulation in the drug discovery process. It also explores the application of quantum mechanics in order to provide better accuracy when calculating protein-ligand binding interactions and predicting binding affinities. In closing, the book provides illustrative descriptions of major challenges associated with computer-aided drug discovery for the development of therapeutic drugs. Given its scope, it offers a valuable asset for life sciences researchers, medicinal chemists and bioinformaticians looking for the latest information on computer-aided methodologies for drug development, together with their applications in drug discovery.
| Author | : Michel Tibayrenc |
| Publisher | : Elsevier |
| Total Pages | : 1002 |
| Release | : 2024-07-19 |
| Genre | : Medical |
| ISBN | : 0443288194 |
Genetics and Evolution of Infectious Diseases, Third Edition discusses the evolving field of infectious diseases and their continued impact on the health of populations, especially in resource-limited areas of the world where they must confront the dual burden of death and disability due to infectious and chronic illnesses. Although substantial gains have been made in public health interventions for the treatment, prevention, and control of infectious diseases, in recent decades the world has witnessed the emergence of the human immunodeficiency virus (HIV) and the COVID-19 pandemic, increasing antimicrobial resistance, and the emergence of many new bacterial, fungal, parasitic, and viral pathogens. Fully updated and revised, this new edition presents the consequences of such diseases, the evolution of infectious diseases, the genetics of host-pathogen relationship, and the control and prevention strategies that are, or can be, developed. This book offers valuable information to biomedical researchers, clinicians, public health practitioners, decisions-makers, and students and postgraduates studying infectious diseases, microbiology, medicine, and public health that is relevant to the control and prevention of neglected and emerging worldwide diseases. - Takes an integrated approach to infectious diseases - Provides the latest developments in the field of infectious diseases - Focuses on the contribution of evolutionary and genomic studies for the study and control of transmissible diseases - Includes updated and revised contributions from leading authorities, along with six new chapters
| Author | : Hifzur R. Siddique |
| Publisher | : Frontiers Media SA |
| Total Pages | : 316 |
| Release | : 2023-06-29 |
| Genre | : Science |
| ISBN | : 2832527655 |
| Author | : Yuangang Liu |
| Publisher | : Frontiers Media SA |
| Total Pages | : 257 |
| Release | : 2023-02-17 |
| Genre | : Science |
| ISBN | : 2832515061 |
| Author | : Timir Tripathi |
| Publisher | : Academic Press |
| Total Pages | : 716 |
| Release | : 2022-01-14 |
| Genre | : Science |
| ISBN | : 0323902650 |
Advances in Protein Molecular and Structural Biology Methods offers a complete overview of the latest tools and methods applicable to the study of proteins at the molecular and structural level. The book begins with sections exploring tools to optimize recombinant protein expression and biophysical techniques such as fluorescence spectroscopy, NMR, mass spectrometry, cryo-electron microscopy, and X-ray crystallography. It then moves towards computational approaches, considering structural bioinformatics, molecular dynamics simulations, and deep machine learning technologies. The book also covers methods applied to intrinsically disordered proteins (IDPs)followed by chapters on protein interaction networks, protein function, and protein design and engineering. It provides researchers with an extensive toolkit of methods and techniques to draw from when conducting their own experimental work, taking them from foundational concepts to practical application. - Presents a thorough overview of the latest and emerging methods and technologies for protein study - Explores biophysical techniques, including nuclear magnetic resonance, X-ray crystallography, and cryo-electron microscopy - Includes computational and machine learning methods - Features a section dedicated to tools and techniques specific to studying intrinsically disordered proteins
| Author | : Dev Bukhsh Singh |
| Publisher | : Springer Nature |
| Total Pages | : 387 |
| Release | : 2023-03-01 |
| Genre | : Psychology |
| ISBN | : 981198249X |
This book provides an overview of the essential characteristics and clinical applications of therapeutic proteins against human diseases, including cancers, immune disorders, infections, and other diseases. It presents the latest advancements in protein engineering techniques for producing desirable therapeutic proteins. The book also covers the strategies used to formulate and deliver systemic therapeutic proteins, approved protein therapeutics and their targets, and pharmacogenetic biomarkers. Further, it discusses challenges associated with the clinical implications of therapeutic proteins, including safety, immunogenicity, protein stability, degradation, and efficacy. It illustrates the development of biosimilar antibodies, optimization strategies for producing biobetter antibodies, and presents fundamental concepts about biosuperior therapeutics. Lastly, it includes a discussion about protein-based vaccines against bacterial and viral infections.
| Author | : Prakash Saudagar |
| Publisher | : Elsevier |
| Total Pages | : 560 |
| Release | : 2022-09-28 |
| Genre | : Science |
| ISBN | : 0323993664 |
Advanced Spectroscopic Methods to Study Biomolecular Structure and Dynamics presents the latest emerging technologies in spectroscopy and advances in established spectroscopic methods. The book presents a guide to research methods in biomolecular spectroscopy, providing comprehensive coverage of developments in the spectroscopic techniques used to study protein structure and dynamics. Seventeen chapters from leading researchers cover key aspects of spectroscopic methods, with each chapter covering structure, folding, and dynamics. This title will help researchers keep up-to-date on the latest novel methods and advances in established methods. - Presents current, emerging, and evolving advances and applications of spectroscopic techniques in the study of biomolecules, including proteins and nucleic acids - Discusses contemporary spectroscopic techniques used to study biomolecular structure, interaction, and dynamics
| Author | : Prakash Saudagar |
| Publisher | : Springer Nature |
| Total Pages | : 287 |
| Release | : 2023-05-27 |
| Genre | : Science |
| ISBN | : 9819920795 |
This book describes recent important advancements in protein folding dynamics and stability research, as well as explaining fundamentals and examining potential methodological approaches in protein science. In vitro, in silico, and in vivo method based research of how the stability and folding of proteins help regulate the cellular dynamics and impact cell function that are crucial in explaining various physiological and pathological processes. This book offers a comprehensive coverage on various techniques and related recent developments in the experimental and computational methods of protein folding, dynamics, and stability studies. The book is also structured in such a way as to summarize the latest developments in the fiddle and key concepts to ensure that readers can understand advanced concepts as well as the fundamental big picture. And most of all, fresh insights are provided into the convergence of protein science and technology. Protein Folding Dynamics and Stability is an ideal guide to the field that will be of value for all levels of researchers and advanced graduate students with training in biochemical laboratory research.
| Author | : Anupam Das Talukdar |
| Publisher | : Springer Nature |
| Total Pages | : 660 |
| Release | : |
| Genre | : |
| ISBN | : 9819746000 |
| Author | : Visakh P. M. |
| Publisher | : Springer Nature |
| Total Pages | : 271 |
| Release | : 2022-09-15 |
| Genre | : Technology & Engineering |
| ISBN | : 3031133439 |
This book provides cutting-edge, up-to-date research findings on the use of bionanocomposites in biodegradable and environmental applications, while also detailing how to achieve bionanocomposites preparation, characteristics, and significant enhancements in physical, chemical, mechanical, thermal properties and applications. This book on biodegradable and environmental properties of bionanocomposites provides a comprehensive and updated review of major innovations in the field of polymer-based bionanocomposites for biodegradable and environmental applications. It covers properties and applications, including the synthesis of polymer-based bionanocomposites from different sources biomaterials-based composites and tactics on the efficacy and major challenges associated with successful scale-up fabrication on bionanocomposites. It is an essential reference for future research in bionanocomposites as topics such as sustainable, biodegradable, and environmental methods for highly innovative and applied materials are current topics of importance. The book covers a wide range of research on bionanocomposite and their biodegradable and environmental applications. Updates on the most relevant polymer-based bionanocomposite and their prodigious potential in the fields of biodegradable and the environment are presented. Leading researchers from industry, academy, government, and private research institutions across the globe contribute to this book. Scientists, engineers, and students with interest in the most important advancements in the field of bionanocomposites involving high-performance bionanocomposites will benefit from this book which is highly application-oriented.
