Immunosenescence and Multiple Sclerosis: Prognostic and Therapeutic Implications
| Author | : Emanuele D’amico |
| Publisher | : Frontiers Media SA |
| Total Pages | : 144 |
| Release | : 2022-10-13 |
| Genre | : Medical |
| ISBN | : 2832502326 |
Immunosenescence And Multiple Sclerosis Prognostic And Therapeutic Implications
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Neuropsychiatric Disorders and Epigenetics
| Author | : Jacob Peedicayil |
| Publisher | : Elsevier |
| Total Pages | : 418 |
| Release | : 2023-09-29 |
| Genre | : Science |
| ISBN | : 0443185174 |
Neuropsychiatric Disorders and Epigenetics, Second Edition is a comprehensive reference on the epigenetic basis of common neuropsychiatric disorders. The volume is organized into chapters covering individual neuropsychiatric disorders, from addiction to anxiety and autism spectrum disorders, and is contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of associated epigenetic mechanisms, including DNA modification, histone post-translational modification, chromatin organization, and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant to disease.This new edition has been fully updated to reflect recent research advances enabled by genomic technologies, as well as therapeutic interventions for previously unmanageable disorders. Several new chapters have been added on disorders or approaches not considered in the earlier edition, including epigenetics and anxiety disorders, epigenetics and neuroimaging in neuropsychiatric disorders, genome-wide approaches to epigenetic research, and the epigenetics of spinal muscular atrophy. By helping to define epigenetics as a key player in neuropsychiatric disorders, this volume empowers new research, clinical translation, and pharmacological advances, and highlights promising directions for ongoing investigation. - Analyzes the effects of environmental stimuli on epigenetic states that correlate with neuropsychiatric disease induction - Reviews the epigenetic basis for common neuropsychiatric disorders, thereby guiding translational therapies for clinicians and mechanistic studies for scientists - Features extensive use of diagrams, illustrations, tables, and graphical abstracts for each section to reinforce understanding - - Includes chapter contributions from leading global experts
Neuroimmunological Diseases
| Author | : Susumu Kusunoki |
| Publisher | : Springer |
| Total Pages | : 292 |
| Release | : 2016-06-24 |
| Genre | : Medical |
| ISBN | : 4431555943 |
This book offers a detailed review of the remarkable advances that have been made in research on the pathogenesis of a number of neuroimmunological diseases, as well as outlining novel treatments including the use of monoclonal antibodies. Written by renowned experts who have made major contributions in the field, such as identifying neuromyelitis optica as an immunopathological clinical condition, identifying the role of ganglioside and ganglioside-complex antibodies in Guillain-Barré syndrome, and developing a novel treatment for POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes) syndrome, the book summarizes recent advances in basic and clinical research. Neuroimmunological Diseases is a useful resource for not only researchers but also neurologists who are engaged in the management of neuroimmunological diseases.
Aging in multiple sclerosis: from childhood to old age, in women and men
| Author | : Alessandra Lugaresi |
| Publisher | : Frontiers Media SA |
| Total Pages | : 152 |
| Release | : 2024-02-21 |
| Genre | : Medical |
| ISBN | : 2832543391 |
In recent years attention has been drawn on changes in multiple sclerosis (MS) prevalence according to sex and age. We are now aware that MS is not a disease with onset exclusively in the young adult, but that pediatric cases are not infrequent, as well as onset in older adults. The need to assess the role of aging, sexual hormones, diet, and infections, has boosted research in many areas, from immunology to imaging techniques to psychology. An increasing awareness of the impact of MS on personal and sexual relationships, with the need to assess patient related outcomes also in clinical trials, has driven research not only in psychology, but in many other areas. The need to integrate information from all these different research areas is deeply felt.
Immune Aspects of Biopharmaceuticals and Nanomedicines
| Author | : Raj Bawa |
| Publisher | : CRC Press |
| Total Pages | : 556 |
| Release | : 2019-01-10 |
| Genre | : Medical |
| ISBN | : 1351399772 |
The enormous advances in the immunologic aspects of biotherapeutics and nanomedicines in the past two decades has necessitated an authoritative and comprehensive reference source that can be relied upon by immunologists, biomedical researchers, clinicians, pharmaceutical companies, regulators, venture capitalists, and policy makers alike. This text provides a thorough understanding of immunology, therapeutic potential, clinical applications, adverse reactions, and approaches to overcoming immunotoxicity of biotherapeutics and nanomedicines. It also tackles critical, yet often overlooked topics such as immune aspects of nano-bio interactions, current FDA regulatory guidances, complement activation-related pseudoallergy (CARPA), advances in nanovaccines, and immunogenicity testing of protein therapeutics.
Cerebrospinal Fluid Biomarkers
| Author | : Charlotte E. Teunissen |
| Publisher | : Humana |
| Total Pages | : 236 |
| Release | : 2022-05-19 |
| Genre | : Medical |
| ISBN | : 9781071613214 |
This volume covers the latest methods used in clinical neurochemistry laboratories for both clinical practice and research. Chapters in this book discuss topics such as techniques for cerebrospinal fluid (CSF) collection, pre-analytical processing, and basic CSF analysis; an examination of biomarkers including ELISA and automated immunochemical assays for amyloid and tau markers for Alzheimer’s disease; the analysis of neurofilaments by digital ELISA; and an example of successful novel immunoassay development. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and thorough, Cerebrospinal Fluid Biomarkers is a valuable resource for clinicians and researchers to use in CSF labs and CSF courses.
New Insights Into B cell Subsets in Health and Disease
| Author | : Judith Fraussen |
| Publisher | : Frontiers Media SA |
| Total Pages | : 232 |
| Release | : 2022-03-04 |
| Genre | : Medical |
| ISBN | : 2889745651 |
Brain and Spinal Cord Atrophy in Multiple Sclerosis
| Author | : Robert Zivadinov |
| Publisher | : Nova Publishers |
| Total Pages | : 220 |
| Release | : 2005 |
| Genre | : Medical |
| ISBN | : 9781594541605 |
Intended for general neurologists as well as specialists in multiple sclerosis (MS) and imaging, this book provides comprehensive discussion of central nervous system (CNS) atrophy involving the brain and spinal cord, and both the chapter authors and topics have been selected to provide state-of-the-art reviews. Key issues covered in the book include pathogenesis and its mechanisms, technical aspects of MRI measurement, the relationship between CNS atrophy and other MRI metrics, clinical relevance, the association with neurobehavioral and genetic-immunologic components of MS, and the effects of disease-modifying therapies on tissue atrophy. Pros and cons of different technical approaches are discussed critically. Special attention is devoted to CNS atrophy as a clinically relevant biologic marker of the MS disease process.
Models, Molecules and Mechanisms in Biogerontology
| Author | : Pramod C. Rath |
| Publisher | : |
| Total Pages | : |
| Release | : 2019 |
| Genre | : Aging |
| ISBN | : 9789811335860 |
This book examines the basic cellular and molecular mechanisms associated with aging. It comprehensively describes the genetic, epigenetic, biochemical and metabolic regulation of aging, as well as some important age-related diseases. Divided into two major sections, it takes readers through the various aspects of aging in a story-like manner and suggests various interventions for healthy aging, such as dietary restriction, regular exercise, nutrition and maintaining a balanced and a non-stressful lifestyle. It describes the implications of aging on the nervous system, metabolism, immunity and stem cells as well as care for the elderly. The book is an ideal companion for both new and established researchers in the field and is also useful for educators, clinicians and policy makers.
Handbook on Immunosenescence
| Author | : Tamas Fulop |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 1693 |
| Release | : 2009-02-27 |
| Genre | : Medical |
| ISBN | : 1402090633 |
This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.
