Immunomagnetic Microfluidic Screening System For Circulating Tumor Cells Detection And Analysis
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| Author | : Shay Soker |
| Publisher | : Humana Press |
| Total Pages | : 225 |
| Release | : 2017-10-20 |
| Genre | : Medical |
| ISBN | : 3319605119 |
Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.
| Author | : Ke Xu |
| Publisher | : Intechopen |
| Total Pages | : 268 |
| Release | : 2016-09-14 |
| Genre | : Medical |
| ISBN | : 953512630X |
The key aim of the proposed chapter is to provide readers a brief description for the most important parts of the field of circulating tumor cells (CTCs): the core techniques, including negative and positive selection-based CTC isolation, and the differences between them. Most importantly, we will also review the clinical applications and important findings in clinical trials. The evidence-based review will not only help clinicians use CTCs to predict recurrence and foresee the disease-related outcomes but also to inspire the researchers in this field to conduct further investigations.
| Author | : Sinem Nalbantoglu |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 168 |
| Release | : 2019-11-06 |
| Genre | : Science |
| ISBN | : 183962759X |
Molecular medicine is an applied science focused on human genes/transcripts, proteins, metabolites, and metabolic networks that describes molecular and cellular processes of health and disease onset and progression. Molecular medicine-based integrative identification and characterization of biomarker targets and their clinical translations is essential to explain/decipher the mechanism(s) underlying physiological pathways and pathological conditions, and acquire cell-targeted early interventional and therapeutic strategies in the context of precision medicine and public health. Principally, Molecular Medicine provides an overview of the latest headlines/developments of systems and molecular medicine, highlighting the emerging high-throughput technologies, promising potential applications, and progress in biomedical research and development strategies.
| Author | : Danny van Noort |
| Publisher | : MDPI |
| Total Pages | : 200 |
| Release | : 2019-10-23 |
| Genre | : Technology & Engineering |
| ISBN | : 3039215620 |
Microfluidics-based devices play an important role in creating realistic microenvironments in which cell cultures can thrive. They can, for example, be used to monitor drug toxicity and perform medical diagnostics, and be in a static-, perfusion- or droplet-based device. They can also be used to study cell-cell, cell-matrix or cell-surface interactions. Cells can be either single cells, 3D cell cultures or co-cultures. Other organisms could include bacteria, zebra fish embryo, C. elegans, to name a few.
| Author | : Y. C. Fung |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 443 |
| Release | : 2013-06-29 |
| Genre | : Medical |
| ISBN | : 1475717520 |
The motivation for writing aseries ofbooks on biomechanics is to bring this rapidly developing subject to students of bioengineering, physiology, and mechanics. In the last decade biomechanics has become a recognized disci pline offered in virtually all universities. Yet there is no adequate textbook for instruction; neither is there a treatise with sufficiently broad coverage. A few books bearing the title of biomechanics are too elementary, others are too specialized. I have long feIt a need for a set of books that will inform students of the physiological and medical applications of biomechanics, and at the same time develop their training in mechanics. We cannot assume that all students come to biomechanics already fully trained in fluid and solid mechanics; their knowledge in these subjects has to be developed as the course proceeds. The scheme adopted in the present series is as follows. First, some basic training in mechanics, to a level about equivalent to the first seven chapters of the author's A First Course in Continuum Mechanics (Prentice-Hall,lnc. 1977), is assumed. We then present some essential parts of biomechanics from the point of view of bioengineering, physiology, and medical applications. In the meantime, mechanics is developed through a sequence of problems and examples. The main text reads like physiology, while the exercises are planned like a mechanics textbook. The instructor may fil1 a dual role: teaching an essential branch of life science, and gradually developing the student's knowledge in mechanics.
| Author | : Vishnu Kirthi Arivarasan |
| Publisher | : Springer Nature |
| Total Pages | : 274 |
| Release | : 2021-01-21 |
| Genre | : Science |
| ISBN | : 3030610217 |
Nanomedicine is the field of science that deals with organic applications of medicine at the nano-scale level. It primarily addresses finding, anticipating, and treating sickness, as well as using nanotechnology to assist in controlling human frameworks at the cellular level. The nature of nanotechnology allows it to address numerous medical issues in humans. This book offers comprehensive information to better comprehend and apply multifunctional nanoparticles in nanomedicine, and thus open avenues in the field. Medicating at the nanolevel is an exceptional therapeutic avenue, as it avoids symptoms associated with conventional medicines. This book investigates recent insights into structuring novel drug delivery frameworks. It concentrates on the physical characteristics of drug delivery transporters, and the preliminary procedures involved in their use. The book offers in-depth detail that benefits academics and researchers alike, containing broad research from experts in the field, and serves as a guide for students and researchers in the field of nanomedicine, drug delivery, and nanotechnology.
| Author | : Fan Xia |
| Publisher | : Springer |
| Total Pages | : 220 |
| Release | : 2018-01-09 |
| Genre | : Science |
| ISBN | : 9811078351 |
This book shows the various sandwich assays that are constructed from recognition molecules, such as antibodies, oligonucleotide sequences and aptamers, developed as a result of nano- and biotechnology advances. It consists of ten chapters presenting interesting examples of these assays, organized according to the type of analytic methods (colorimetric, fluorescence, electrochemical, etc.) and detected objects (protein, nucleic acid, small-molecule, ion, etc.). It also includes a chapter discussing the introduction of sandwich assays as biosensors for the detection of a range of targets. It is an interesting and useful resource for a wide readership in various fields of chemical science and nanotechnology.
| Author | : Giampietro Gasparini |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 335 |
| Release | : 2008-01-17 |
| Genre | : Medical |
| ISBN | : 159259915X |
Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines for the validation studies of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators. Highlights include the evaluation of HER2 and EGFR family members, of p53, and of UPA/PAI-1; the detection of rare cells in blood and marrow; and the detection and analysis of soluble, circulating markers.
| Author | : Serge Cosnier |
| Publisher | : CRC Press |
| Total Pages | : 405 |
| Release | : 2015-01-26 |
| Genre | : Science |
| ISBN | : 9814411477 |
Since four decades, rapid detection and monitoring in clinical and food diagnostics and in environmental and biodefense have paved the way for the elaboration of electrochemical biosensors. Thanks to their adaptability, ease of use in relatively complex samples, and their portability, electrochemical biosensors now are one of the mainstays of analy
| Author | : Stephen E. Saddow |
| Publisher | : Elsevier |
| Total Pages | : 370 |
| Release | : 2022-07-13 |
| Genre | : Technology & Engineering |
| ISBN | : 0323908268 |
After over two decades of focused research and development, silicon carbide (SiC) is now ready for use in the healthcare sector and Silicon Carbide Technology for Advanced Human Healthcare Applications provides an up-to-date assessment of SiC devices for long-term human use. It explores a plethora of applications that SiC is uniquely positioned for in human healthcare, beginning with the three primary areas of technology which are closest to human trials and thus adoption in the healthcare industry: neural implants and spinal cord repair, graphene and biosensors, and finally deep tissue cancer therapy using SiC nanotechnology. Biomedical-inspired engineers, scientists, and healthcare professionals will find this book to be very useful in two ways: (I) as a guide to new ways to design and develop advanced medical devices and (II) as a reference for new developments in the field. The book's intent is to stimulate ideas for further technological enhancements and breakthroughs, which will provide alternative solutions for human healthcare applications. - Discusses the utilization of SiC materials for biomedical applications - Provides a logical pathway to understand why SiC is ideal for several critical applications, in particular for long-term implantable devices, and will serve as a guide to new ways to design and develop advanced medical devices - Serves as a reference for new developments in the field and as a technology resource for medical doctors and practitioners looking to identify and implement advanced engineering solutions to everyday medical challenges that currently lack long-term, cost-effective solutions
