Identifying Novel Biomarkers In Bladder Cancer 2nd Edition
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| Author | : Thornsten Ecke |
| Publisher | : Frontiers Media SA |
| Total Pages | : 262 |
| Release | : 2023-07-18 |
| Genre | : Science |
| ISBN | : 2832530516 |
Bladder cancer is one of the most common urological diseases with a high mortality rate and poor prognosis. It is currently ranked as the 10th most common malignancy worldwide. The majority of bladder cancer patients have been found to be diagnosed with non-muscle invasive bladder cancer (NMIBC) and the remaining, are diagnosed with muscle-invasive bladder cancer (MIBC). Although there have been advances in the treatment and therapies provided for bladder cancer patients, the survival rate remains low, primarily due to recurrence and metastasis of the disease following treatment. Surgical treatment is currently the most common form including radical cystectomy which is the standard form of treatment combined with neoadjuvant chemotherapy. However, the 5-year overall survival rate is 50%. Therefore, further studies are required to understand the molecular mechanisms involved in the progression of bladder cancer and identify novel biomarkers to act as a diagnostic tool for patients. There have been many studies involving the detection of biomarkers in bladder cancer in addition to monitoring disease recurrence to understand the impact and predict potential outcomes. A variety of urine biomarkers have been developed to detect bladder cancer and prognostic risk stratification including mutational DNA and the levels of RNA expression. Circulating tumor cells have also been identified as a potential biomarker for bladder cancer patients. However, there are significant challenges as bladder cancer has demonstrated high levels of cellular and molecular heterogeneity and some markers do not have sufficient sensitivity for accurate detection. Therefore, further studies are required to continue to identify new novel biomarkers for bladder cancer. The aim of this Research Topic is to discuss novel biomarkers in bladder cancer and how it impacts the disease progression and the survival rate for bladder cancer patients.
| Author | : Thorsten Ecke |
| Publisher | : Frontiers Media SA |
| Total Pages | : 259 |
| Release | : 2023-04-27 |
| Genre | : Medical |
| ISBN | : 2832521886 |
| Author | : |
| Publisher | : ScholarlyEditions |
| Total Pages | : 192 |
| Release | : 2012-01-09 |
| Genre | : Medical |
| ISBN | : 146490118X |
Bladder Cancer: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Bladder Cancer. The editors have built Bladder Cancer: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Bladder Cancer in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Bladder Cancer: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
| Author | : Victor R. Preedy |
| Publisher | : |
| Total Pages | : |
| Release | : |
| Genre | : Tumor markers |
| ISBN | : 9789400777446 |
| Author | : United States. Public Health Service. Office of the Surgeon General |
| Publisher | : |
| Total Pages | : 728 |
| Release | : 2010 |
| Genre | : Government publications |
| ISBN | : |
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
| Author | : Kecheng Zhang |
| Publisher | : Frontiers Media SA |
| Total Pages | : 394 |
| Release | : 2024-07-31 |
| Genre | : Science |
| ISBN | : 2832552366 |
Gastric cancer (GC) represents a serious health problem on a global scale. Despite some recent advances in the field, the prognosis in GC remains poor. A better understanding of molecular biology, which would lead to improved treatment options, is needed. Many potential biomarkers of prognostic significance have been identified. However, inhibition of only HER2 protein has led to a modest survival benefit. A deeper understanding of the pathogenesis and biological features of gastric cancer, including the identification and characterization of diagnostic, prognostic, predictive, and therapeutic biomarkers, hopefully will provide improved clinical outcomes. This Research Topic aims to provide a comprehensive overview on recent progress in emerging molecular biomarkers for gastric cancer. We welcome the submission of Review and Original Research articles covering, but not limited to, the following topics: 1)Novel diagnostic molecules to improve the early detection rate for gastric cancer 2)Novel prognostic molecules to stratify gastric cancer patients into different risk 3)Novel therapeutic biomarker which could serve as target for treating gastric cancer 4)Novel biomarker to predict chemotherapy response of gastric cancer patients
| Author | : Abdullah Erdem Canda |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 474 |
| Release | : 2012-02-01 |
| Genre | : Medical |
| ISBN | : 9533078391 |
This book is an invaluable source of knowledge on bladder cancer biology, epidemiology, biomarkers, prognostic factors, and clinical presentation and diagnosis. It is also rich with plenty of up-to-date information, in a well-organized and easy to use format, focusing on the treatment of bladder cancer including surgery, chemotherapy, radiation therapy, immunotherapy, and vaccine therapy. These chapters, written by the experts in their fields, include many interesting, demonstrative and colorful pictures, figures, illustrations and tables. Due to its practicality, this book is recommended reading to anyone interested in bladder cancer.
| Author | : Jinghua Pan |
| Publisher | : Frontiers Media SA |
| Total Pages | : 493 |
| Release | : 2023-07-11 |
| Genre | : Medical |
| ISBN | : 2832525490 |
Immunotherapy has revolutionized the treatment of malignancies. Targeting of immune checkpoints cytotoxic T-lymphocyte-associated protein 4, programmed cell death protein 1 (PD-1) and its ligand (PD-L1) has led to improving survival in a subset of patients. Despite their remarkable success, clinical benefit remains limited to only a subset of patients. A significant limitation behind these current treatment modalities is an irregularity in clinical response, which is especially pronounced among checkpoint inhibition. Currently, relevant predictors of cancer immunotherapy response include microsatellite instability-high/deficient mismatch repair (MSI-H/dMMR), expression of PD-L1, tumor mutation burden (TMB), immune genomic characteristics, and tumor infiltrating lymphocytes (TILs). However, none of them have sufficient evidence to be a stratification factor. Moreover, as the combined strategies for effective cancer immunotherapy had been developed in multiple tumors, such as Immunotherapy combined with chemotherapy, radiotherapy, targeted therapy and anti-angiogenesis therapy. Therefore, the development of novel biomarkers endowed with high sensitivity, specificity and accuracy able to identify which patients may truly benefit from the treatment with cancer immunotherapy would allow to refine the therapeutic selection and to better tailor the treatment strategy.
| Author | : Jerry J. Zimmerman |
| Publisher | : Elsevier Health Sciences |
| Total Pages | : 1769 |
| Release | : 2011-03-24 |
| Genre | : Medical |
| ISBN | : 0323081703 |
Provide the latest in superior quality care for critically ill children with the full-color, updated 4th Edition of Fuhrman and Zimmerman’s Pediatric Critical Care. In print, and now online, Drs. Bradley P. Fuhrman and Jerry J. Zimmerman use a comprehensive, organ-systems approach to help you manage a full range of disease entities. Get up-to-the-minute knowledge of topics such as acute lung injury, multiple organ dysfunction syndrome, and more. Implement new clinical techniques and diagnostic tests, weigh the varying perspectives of six associate editors with expertise in the field, reference 1,000+ illustrations to aid diagnosis, and keep sharp with online access to board-style review questions. This definitive title will ensure that you consistently deliver the very best intensive care to your pediatric patients. Focus on the development, function, and treatment of a wide range of disease entities with the text’s clear, logical, organ-system approach. Keep all members of the pediatric ICU team up to date with coverage of topics particularly relevant to their responsibilities. Keep current with the latest developments in palliative care, mass casualty/epidemic disease, acute respiratory failure, non-invasive ventilation, neurocritical care, neuroimaging, hypoxic-ischemic encephalopathy, stroke and intracerebral hemorrhage, systemic inflammatory response syndrome, acute lung injury, multiple organ dysfunction syndrome, and much more. Quickly find the information you need with sections newly reorganized for easier access. Gain the perspectives of six expert associate editors on all the new developments in the field. Understand complex concepts quickly and conclusively with a brand new full-color format and more than 1,000 illustrations. Search the full text, download the image library, and access online board review questions targeting every relevant topic, all at www.expertconsult.com.
| Author | : Ja Hyeon Ku |
| Publisher | : Frontiers Media SA |
| Total Pages | : 193 |
| Release | : 2021-05-31 |
| Genre | : Medical |
| ISBN | : 2889668207 |
