Disorders of Hemoglobin

Disorders of Hemoglobin
Author: Martin H. Steinberg
Publisher: Cambridge University Press
Total Pages: 883
Release: 2009-08-17
Genre: Medical
ISBN: 0521875196

Completely revised new edition of the definitive reference on disorders of hemoglobin.

Human Hemoglobin Genetics

Human Hemoglobin Genetics
Author: G.R. Honig
Publisher: Springer Science & Business Media
Total Pages: 460
Release: 2012-12-06
Genre: Medical
ISBN: 3709187982

The discovery in the late 1940's that sickle cell anemia is a "molecular disease" of hemoglobin was the crucial advance that gave birth to the scientific discipline of human molecular genetics. In subsequent years, with the continued expansion of knowledge about the biology and genetics of the hemoglobins, and particularly as a result of the characterization of the very large numbers of globin gene mutations, the human hemoglobin system has remained as the premier model of gene expression at the molecular level in man. With the recent explosion of new information about the genetic properties of the hemoglobins, it appears inevitable that this gene system will continue to occupy a unique position in human molecular genetics for many years in the future. Hemoglobin genetics has also recently come of age as a diagnostic and clinical discipline. The heightening of public awareness in recent years about sickle cell disease, thalassemia, and other inherited disorders has brought increasing demands for carrier detection services as well as for genetic counseling and education. The more recent development of prac tical and reliable methods for the antenatal diagnosis of hemoglobin dis orders has further increased the scope of clinical hemoglobin genetics, and it can be anticipated that these potent diagnostic techniques will have increasing application in the years ahead.

Conference on Hemoglobin, 2-3 May 1957

Conference on Hemoglobin, 2-3 May 1957
Author: National Research The Division of Medical Sciences the National Heart Institute National Institutes of Health
Publisher: National Academies
Total Pages: 338
Release: 1958
Genre: Hemoglobin
ISBN:

The Thalassaemia Syndromes

The Thalassaemia Syndromes
Author: David J. Weatherall
Publisher: John Wiley & Sons
Total Pages: 864
Release: 2008-04-30
Genre: Medical
ISBN: 0470695943

In the new edition of this successful and authoritative book, the thalassaemias are reviewed in detail with respect to their clinical features, cellular pathology, molecular genetics, prevention and treatment. It is aimed at specialists in haematology in the laboratory or clinical setting, particularly in areas where thalassaemia is common either in the native population or in immigrant communities. The fourth edition has been both updated and re-organized. Three new chapters have been added on the link between alpha-thalassaemia and mental retardation, on avoidance and population control and on global epidemiology. Considerable emphasis is placed on molecular pathology reflecting the huge burst of information to have come out of this field in the last few years.

Genomic Medicine

Genomic Medicine
Author: Dhavendra Kumar
Publisher: Oxford Monographs on Medical G
Total Pages: 853
Release: 2014-10-15
Genre: Medical
ISBN: 019989602X

Preceded by Genomics and clinical medicine / edited by Dhavendra Kumar. [First edition]. 2008.

Vertebrate and Invertebrate Respiratory Proteins, Lipoproteins and other Body Fluid Proteins

Vertebrate and Invertebrate Respiratory Proteins, Lipoproteins and other Body Fluid Proteins
Author: Ulrich Hoeger
Publisher: Springer Nature
Total Pages: 527
Release: 2020-03-18
Genre: Science
ISBN: 3030417697

This book focuses on respiratory proteins, the broad hemoglobin family, as well as the molluscan and arachnid hemocyanins (and their multifunctional roles). Featuring 20 chapters addressing invertebrate and vertebrate respiratory proteins, lipoproteins and other body fluid proteins, and drawing on the editors’ extensive research in the field, it is a valuable addition to the Subcellular Biochemistry book series. The book covers a wide range of topics, including lipoprotein structure and lipid transport; diverse annelid, crustacean and insect defense proteins; and insect and vertebrate immune complexes. It also discusses a number of other proteins, such as the hemerythrins; serum albumin; serum amyloid A; von Willebrand factor and its interaction with factor VIII; and C-reactive protein. Given its scope, the book appeals to biologists, biomedical scientists and clinicians, as well as advanced undergraduates and postgraduates in these disciplines. Available as a printed book and also as an e-book and e-chapters, the fascinating material included is easily accessible.

Turning Blood Red: The Fight For Life In Cooley's Anemia

Turning Blood Red: The Fight For Life In Cooley's Anemia
Author: Arthur Bank
Publisher: World Scientific Publishing Company
Total Pages: 288
Release: 2008-11-28
Genre: Medical
ISBN: 9814338400

This book is the story of an inherited blood disease — Cooley's anemia or beta thalassemia. Cooley's anemia is a severe and potentially fatal anemia that affects millions of people worldwide. Written by a world-recognized expert on the disease who has contributed greatly to the scientific understanding of the pathophysiology of this human hemoglobin disorder, the book describes the emotional and medical impact of the disease on patients and their families. It also summarizes the research on the disease at the level of the genes, DNA, RNA, and proteins. In addition, it also includes chapters on current therapy and future approaches to the disease, such as gene therapy, stem cell transplantation, and antenatal diagnosis.A multidisciplinary book covering the fields of hematology, pediatrics, medicine, genetics, and molecular biology, the book details how Cooley's anemia serves as a model for understanding other human genetic and acquired diseases such as cancer, neurological disorders, and heart disease. It also provides new insights which may lead to new therapies.

Coevolution

Coevolution
Author: William H. Durham
Publisher: Stanford University Press
Total Pages: 658
Release: 1991
Genre: Social Science
ISBN: 9780804721561

Charles Darwin's "On the Origins of Species" had two principal goals: to show that species had not been separately created and to show that natural selection had been the main force behind their proliferation and descent from common ancestors. In "Coevolution," the author proposes a powerful new theory of cultural evolution--that is, of the descent with modification of the shared conceptual systems we call "cultures"--that is parallel in many ways to Darwin's theory of organic evolution. The author suggests that a process of cultural selection, or preservation by preference, driven chiefly by choice or imposition depending on the circumstances, has been the main but not exclusive force of cultural change. He shows that this process gives rise to five major patterns or "modes" in which cultural change is at odds with genetic change. Each of the five modes is discussed in some detail and its existence confirmed through one or more case studies chosen for their heuristic value, the robustness of their data, and their broader implications. But "Coevolution" predicts not simply the existence of the five modes of gene-culture relations; it also predicts their relative importance in the ongoing dynamics of cultural change in particular cases. The case studies themselves are lucid and innovative reexaminations of an array of oft-pondered anthropological topics--plural marriage, sickle-cell anemia, basic color terms, adult lactose absorption, incest taboos, headhunting, and cannibalism. In a general case, the author's goal is to demonstrate that an evolutionary analysis of both genes and culture has much to contribute to our understanding of human diversity, particularly behavioral diversity, and thus to the resolution of age-old questions about nature and nurture, genes and culture.

Abnormal Hemoglobins in Human Populations

Abnormal Hemoglobins in Human Populations
Author: Frank B. Livingstone
Publisher: Transaction Publishers
Total Pages: 490
Release:
Genre: Science
ISBN: 0202364038

Research on abnormal human hemoglobins (protein in blood that carries oxygen), has taught us about the inheritance, biochemistry, and distribution of these traits. Th is knowledge, coupled with mathematical research using computer models of population genetics, has enabled researchers to marry biological fact and genetic theory. This volume places medical understanding in an evolutionary framework. Using published data on the frequencies of abnormal hemoglobins in the world's populations, Livingston analyzes and interprets these frequencies in the light of world distribution of diff erent forms of diseases such as malaria. He further develops the genetic theory of the evolutionary homeostasis. Livingston discusses the relation of abnormal hemoglobins to endemic malaria and, shows how natural selection pressures explain the known distribution of these traits. Where non-coinciding distributions arise, the book presents other genetic, anthropological, evolutionary, and epidemiological evidence to explain these discrepancies. This classic work remains a useful sourcebook for professors and graduate students of anthropology, genetics, epidemiology, and hematology. Frank B. Livingstone was professor emeritus of biological anthropology at the University of Michigan. He recieved the Martin Luther King Award from the Southern Christian Leadership Conference for his groundbreaking research on sickle cell anemia and is the author of Data on the Abnormal Hemoglobin's and Glucose-Six-Phosphate Deficiency in Human Populations. Jonathan Marks is a professor of anthropology, at the University of North Carolina, Charlotte.