Homology Effects
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| Author | : |
| Publisher | : Elsevier |
| Total Pages | : 565 |
| Release | : 2002-04-02 |
| Genre | : Science |
| ISBN | : 0080490328 |
Homology Effects offers contributions from an international panel of researchers whose aim has been both to introduce newcomers to the field of homology effects, and to bring colleagues up to date. Topic coverage includes dosage compensation, X-inactivation, imprinting, paramutation, homology-dependent gene silencing, transvection, pairing-sensitive silencing, nuclear organization of chromosomes, DNA repair, quelling, RIP, RNAi and antisense biology, homology effects in ciliates, prion biology, and a discourse on the evolution of gene duplications. Advances in Genetics presents an eclectic mix of articles of use to all human and molecular geneticists. They are written and edited by recognized leaders in the field and make this an essential series of books for anyone in the genetics field. - Homology, the examination of similarity due to shared common ancestry, encompasses a fascinating class of phenomena in mammals, plants, insects, ciliates, nematodes, fungi, and bacteria. Homology effects concern processes that recognize homology at the level of DNA and/or RNA, as well as at the level of protein. Their collective history begins at the turn of the century and includes some of the most puzzling and extraordinary observations in biology. The volume covers phenomena that have often been considered unusual, exceptional to the rule, and "out of the ordinary" and, therefore, not for general study. However, it is now becoming clear that taken together, these phenomena represent a class of regulatory mechanisms that are widespread, as well as exceptionally powerful.
| Author | : James W. Vick |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 258 |
| Release | : 2012-12-06 |
| Genre | : Mathematics |
| ISBN | : 1461208815 |
This introduction to some basic ideas in algebraic topology is devoted to the foundations and applications of homology theory. After the essentials of singular homology and some important applications are given, successive topics covered include attaching spaces, finite CW complexes, cohomology products, manifolds, Poincare duality, and fixed point theory. This second edition includes a chapter on covering spaces and many new exercises.
| Author | : Peter S. Ozsváth |
| Publisher | : American Mathematical Soc. |
| Total Pages | : 423 |
| Release | : 2015-12-04 |
| Genre | : Education |
| ISBN | : 1470417375 |
Knot theory is a classical area of low-dimensional topology, directly connected with the theory of three-manifolds and smooth four-manifold topology. In recent years, the subject has undergone transformative changes thanks to its connections with a number of other mathematical disciplines, including gauge theory; representation theory and categorification; contact geometry; and the theory of pseudo-holomorphic curves. Starting from the combinatorial point of view on knots using their grid diagrams, this book serves as an introduction to knot theory, specifically as it relates to some of the above developments. After a brief overview of the background material in the subject, the book gives a self-contained treatment of knot Floer homology from the point of view of grid diagrams. Applications include computations of the unknotting number and slice genus of torus knots (asked first in the 1960s and settled in the 1990s), and tools to study variants of knot theory in the presence of a contact structure. Additional topics are presented to prepare readers for further study in holomorphic methods in low-dimensional topology, especially Heegaard Floer homology. The book could serve as a textbook for an advanced undergraduate or part of a graduate course in knot theory. Standard background material is sketched in the text and the appendices.
| Author | : Brian K. Hall |
| Publisher | : Elsevier |
| Total Pages | : 500 |
| Release | : 2013-10-22 |
| Genre | : Mathematics |
| ISBN | : 0080574300 |
The application of homology varies depending on the data being examined. This volume represents a state-of-the-art treatment of the different applications of this unifying concept. Chapters deal with homology on all levels, from molecules to behavior, and are authored by leading contributors to systematics, natural history, and evolutionary, developmental, and comparative biology. This paperback reprint of the original hardbound edition continues to commemorate the 150th anniversary of Sir Richard Owen's seminal paper distinguishing homology from analogy. - Commemoration of the 150th anniversary of Sir Richard Owen's seminal paper distinguishing homology from analogy - Contributors who are renowned leaders in comparative biology - Coverage that is both comprehensive and interdisciplinary
| Author | : Robert Scotland |
| Publisher | : CRC Press |
| Total Pages | : 226 |
| Release | : 2014-04-21 |
| Genre | : Nature |
| ISBN | : 1482268248 |
When looking at groups of organisms, shared characteristics (homologues) provide the raw data from which hypotheses of common ancestry may be suggested. In order to explore the relationship between homologues and particular hypotheses of common ancestry, complex matrices are devised, where homologues are coded, allowing theories of homology to be developed and tested. Practically nothing has been written about this matrix-building process, which is fundamental to our understanding of diversity and evolutionary history. This book fills the gap by discussing the ways observations are coded and the consequences for resulting hypotheses using case studies and theoretical examples.
| Author | : Chris D. Jiggins |
| Publisher | : Oxford University Press |
| Total Pages | : 288 |
| Release | : 2017-01-27 |
| Genre | : Science |
| ISBN | : 0192509071 |
The Heliconius butterflies are one of the classic systems in evolutionary biology and have contributed hugely to our understanding of evolution over the last 150 years. Their dramatic radiation and remarkable mimicry has fascinated biologists since the days of Bates, Wallace, and Darwin. The Ecology and Evolution of Heliconius Butterflies is the first thorough and accessible treatment of the ecology, genetics, and behaviour of these butterflies, exploring how they offer remarkable insights into tropical biodiversity. The book starts by outlining some of the evolutionary questions that Heliconius research has helped to address, then moves on to an overview of the butterflies themselves and their ecology and behaviour before focussing on wing pattern evolution, and finally, speciation. Richly illustrated with 32 colour plates, this book makes the extensive scientific literature on Heliconius butterflies accessible to a wide audience of professional ecologists, evolutionary biologists, entomologists, and amateur collectors.
| Author | : Danny E. Miller |
| Publisher | : John Wiley & Sons |
| Total Pages | : 309 |
| Release | : 2023-08-29 |
| Genre | : Science |
| ISBN | : 1118086929 |
GENETIC THEORY AND ANALYSIS Understand and apply what drives change of characteristic genetic traits and heredity Genetics is the study of how traits are passed from parents to their offspring and how the variation in those traits affects the development and health of the organism. Investigating how these traits affect the organism involves a diverse set of approaches and tools, including genetic screens, DNA and RNA sequencing, mapping, and methods to understand the structure and function of proteins. Thus, there is a need for a textbook that provides a broad overview of these methods. Genetic Theory and Analysis meets this need by describing key approaches and methods in genetic analysis through a historical lens. Focusing on the five basic principles underlying the field—mutation, complementation, recombination, segregation, and regulation—it identifies the full suite of tests and methodologies available to the geneticist in an age of flourishing genetic and genomic research. This second edition of the text has been updated to reflect recent advances and increase accessibility to advanced undergraduate students. Genetic Theory and Analysis, 2nd edition readers will also find: Detailed treatment of subjects including mutagenesis, meiosis, complementation, suppression, and more Updated discussion of epistasis, mosaic analysis, RNAi, genome sequencing, and more Appendices discussing model organisms, genetic fine-structure analysis, and tetrad analysis Genetic Theory and Analysis is ideal for both graduate students and advanced undergraduates undertaking courses in genetics, genetic engineering, and computational biology.
| Author | : Alleyn T. Plowright |
| Publisher | : John Wiley & Sons |
| Total Pages | : 399 |
| Release | : 2019-12-02 |
| Genre | : Medical |
| ISBN | : 3527818251 |
The modern drug developers? guide for making informed choices among the diverse target identification methods Target Discovery and Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation. With contributions from noted industry and academic experts, the book addresses the most recent chemical, biological, and computational methods. Additionally, the book highlights techologies that are applicable to ?difficult? targets and drugs directed at multiple targets, including chemoproteomics, activity-based protein profiling, pathway mapping, genome-wide association studies, and array-based profiling. Throughout, the authors highlight a range of diverse approaches, and target validation studies reveal how these methods can support academic and drug discovery scientists in their target discovery and validation research. This resource: -Offers a guide to identifying and validating targets, a key enabling technology without which no new drug development is possible -Presents the information needed for choosing the appropriate assay method from the ever-growing range of available options -Provides practical examples from recent drug development projects, e. g. in kinase inhibitor profiling Written for medicinal chemists, pharmaceutical professionals, biochemists, biotechnology professionals, and pharmaceutical chemists, Target Discovery and Validation explores the current methods for the identification and validation of drug targets in one comrpehensive volume. It also includes numerous practical examples.
| Author | : National Academy of Sciences (U.S.) |
| Publisher | : |
| Total Pages | : 806 |
| Release | : 1920 |
| Genre | : Electronic journals |
| ISBN | : |
The Proceedings of the National Academy of Sciences (PNAS) publishes research reports, commentaries, reviews, colloquium papers, and actions of the Academy. PNAS is a multidisciplinary journal that covers the biological, physical, and social sciences.
| Author | : Proceedings of the National Academy of Sciences |
| Publisher | : National Academies Press |
| Total Pages | : 303 |
| Release | : 2002-09-18 |
| Genre | : Science |
| ISBN | : 030907424X |
There has been a sea change in how we view genetic recombination. When germ cells are produced in higher organisms, genetic recombination assures the proper segregation of like chromosomes. In the course of that process, called meiosis, recombination not only assures segregation of one chromosome of each type to progeny germ cells, but also further shuffles the genetic deck, contributing to the unique inheritance of individuals. In a nutshell, that is the classical view of recombination. We have also known for many years that in bacteria recombination plays a role in horizontal gene transfer and in replication itself, the latter by establishing some of the replication forks that are the structural scaffolds for copying DNA. In recent years, however, we have become increasingly aware that replication, which normally starts without any help from recombination, is a vulnerable process that frequently leads to broken DNA. The enzymes of recombination play a vital role in the repair of those breaks. The recombination enzymes can function via several different pathways that mediate the repair of breaks, as well as restoration of replication forks that are stalled by other kinds of damage to DNA. Thus, to the classical view of recombination as an engine of inheritance we must add the view of recombination as a vital housekeeping function that repairs breaks suffered in the course of replication. We have also known for many years that genomic instability--including mutations, chromosomal rearrangements, and aneuploidy--is a hallmark of cancer cells. Although genomic instability has many contributing causes, including faulty replication, there are many indications that recombination, faulty or not, contributes to genome instability and cancer as well. The (Nas colloquium) Links Between Recombination and Replication: Vital Roles of Recombination was convened to broaden awareness of this evolving area of research. Papers generated by this colloquium are published here. To encourage the desired interactions of specialists, we invited some contributions that deal only with recombination or replication in addition to contributions on the central thesis of functional links between recombination and replication. To aid the nonspecialist and specialist alike, we open the set of papers with a historical overview by Michael Cox and we close the set with a commentary on the meeting and the field by Andrei Kuzminov.
