Hiv Reservoirs
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| Author | : Guido Poli |
| Publisher | : |
| Total Pages | : 451 |
| Release | : 2022 |
| Genre | : Electronic books |
| ISBN | : 9781071618714 |
This book details the development of methods and models to study the HIV-1 viral reservoir with the ultimate goal of achieving a functional cure of HIV infection. Chapters are divided into six parts covering cell lines, in vitro and ex vivo primary cell models of persistent infection, in vitro and ex vivo tissue-derived models, infected animal models human immune cells, methods of detection and analysis of the reservoir, and current approaches to achieve either a functional cure or cART-free long-term remission. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, HIV Reservoirs: Methods and Protocols provides a comprehensive, updated collection of state-of-art methodologies and models to tackle the HIV-1 viral reservoir.
| Author | : Guido Silvestri |
| Publisher | : Springer |
| Total Pages | : 253 |
| Release | : 2018-10-11 |
| Genre | : Medical |
| ISBN | : 303002816X |
This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.
| Author | : Renee Marije Van Der Sluis |
| Publisher | : Frontiers Media SA |
| Total Pages | : 111 |
| Release | : 2021-04-07 |
| Genre | : Science |
| ISBN | : 2889666662 |
| Author | : Anthony S. Fauci |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 159 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 3642608671 |
During the last 5 years, major advances have been made in our understanding of the pathogenesis of human immunodeficiency virus (HIV) disease and in the development of new potent antiviral agents. With regard to HIV pathogenesis, several recent observations have not only changed our perspectives of HIV disease, but have been critical for the design of therapeutic strategies.
| Author | : Thomas J. Hope |
| Publisher | : |
| Total Pages | : |
| Release | : |
| Genre | : AIDS (Disease) |
| ISBN | : 9781461496106 |
| Author | : Alireza Minagar |
| Publisher | : Nova Publishers |
| Total Pages | : 280 |
| Release | : 2006 |
| Genre | : Medical |
| ISBN | : 9781594546105 |
During the past two decades, the world scientific community has witnessed major achievements in our understanding of the pathogenesis of HIV infection of the nervous system and HIV-Associated Dementia (HAD). Despite these giant gains, nervous system involvement during AIDS remains a relentlessly progressive disease with a deadly fate in many cases. This book on NeuroAIDS provides a unique resource for both general neurologists as well as basic neuroscientists with profound interests for research on NeuroAIDS. This book has special emphasis on the mechanisms of disease development and progression of HIV-infected patients with NeuroAIDS. The contributors have provided the readers with comprehensive reviews on clinical manifestations of HAD, mechanisms of HIV entry into the central nervous system, the role of cytokines and chemokines in pathogenesis of NeuroAIDS, drug abuse and NeuroAIDS, virus load in HAD, allostasis in HIV and AIDS, stroke in AIDS patients, and neuroimaging of HIV infection of the central nervous system. In addition, there are chapters on Varicella Zoster virus infection of HIV-seropositive and AIDS patients, as well as the molecular basis for opioids and AIDS virus interactions.
| Author | : Sujata K. Bhatia |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 286 |
| Release | : 2010-10-14 |
| Genre | : Technology & Engineering |
| ISBN | : 1441969209 |
Biomaterials for Clinical Applications is organized according to the World Health Organization’s report of the top 11 causes of death worldwide, and lays out opportunities for both biomaterials scientists and physicians to tackle each of these leading contributors to mortality. The introductory chapter discusses the global burden of disease. Each of the subsequent eleven chapters focuses on a specific disease process, beginning with the leading cause of death worldwide, cardiovascular disease. The chapters start with describing diseases where clinical needs are most pressing, and then envisions how biomaterials can be designed to address these needs, instead of the more technologically centered approached favored by most books in the field. This book, then, should appeal to chemical engineers and bioengineers who are designing new biomaterials for drug delivery and vaccine delivery, as well as tissue engineering.
| Author | : David Quammen |
| Publisher | : W. W. Norton & Company |
| Total Pages | : 591 |
| Release | : 2012-10 |
| Genre | : Medical |
| ISBN | : 0393066800 |
A masterpiece of science reporting that tracks the animal origins of emerginghuman diseases.
| Author | : David S. Hui |
| Publisher | : European Respiratory Society |
| Total Pages | : 148 |
| Release | : 2016-06-01 |
| Genre | : Medical |
| ISBN | : 1849840709 |
Viral respiratory tract infections are important and common causes of morbidity and mortality worldwide. In the past two decades, several novel viral respiratory infections have emerged with epidemic potential that threaten global health security. This Monograph aims to provide an up-to-date and comprehensive overview of severe acute respiratory syndrome, Middle East respiratory syndrome and other viral respiratory infections, including seasonal influenza, avian influenza, respiratory syncytial virus and human rhinovirus, through six chapters written by authoritative experts from around the globe.
| Author | : John Sidney Oxford |
| Publisher | : Oxford University Press |
| Total Pages | : 365 |
| Release | : 2016 |
| Genre | : Medical |
| ISBN | : 0198714688 |
Written by leading authors in the field with both clinical and molecular expertise, Human Virology provides an accessible introduction to this fascinating and important field, making the text ideal for students encountering virology for the first time.
