This book is designed to describe the environmental, political, socioeconomic, and military life of the inhabitants that surrounded the Mediterranean Sea from the fourth through the second centuries BC. This story relates the complex dynamic interrelationships among the people and states of the Mediterranean basin. The book explores the greater Mediterranean world that stretched from India to Spain. It begins with a review of some of the geographical, environmental, and structural characteristics of the Mediterranean basin. The balance of the book then proceeds to trace the political, military, and economic development of this region. We review the rise of Macedon under Philip II through the conquests of Alexander the Great. In the eastern basin, the development and conflicts of the Hellenistic kingdoms of the Ptolemaic, Seleucid, and Antigonid dynasties are then traced. We then turn the page and discuss the rise of Carthage and Rome as republics in the western basin. Next, the conflict between these two powers is analyzed which leaves Rome supreme in the west. The next chapters narrate the struggle between Rome and the Hellenistic kingdoms for dominance in the east. The book concludes with Roman supremacy established throughout the Mediterranean by the end of the second century. From the apex conqueror of antiquity Alexander the Great, we conclude with the establishment of the apex empire that was Rome.