Heavy Metal Pollution Toxication And Chelation
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| Author | : Jan Aaseth |
| Publisher | : Academic Press |
| Total Pages | : 390 |
| Release | : 2016-04-18 |
| Genre | : Medical |
| ISBN | : 0128030739 |
Chelation Therapy in the Treatment of Metal Intoxication presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system. Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. Chelation Therapy in the Treatment of Metal Intoxication describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptosuccinic acid (DMSA) and D,L-2,3-dimercapto-1-propanesulfonic acid (DMPS). - Presents all the current findings on the potential for chelation as a therapy for metal intoxication - Presents practical guidelines for selecting the most appropriate chelating agent - Includes coverage on radionuclide exposure and metal storage diseases - Describes the chemical and biological principles of chelation in the treatment of toxic metal compounds
| Author | : Ozgur Karcioglu |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 130 |
| Release | : 2019-06-19 |
| Genre | : Medical |
| ISBN | : 1838807853 |
Over 400 years ago, Swiss alchemist and physician Paracelsus (1493-1541) cited: "All substances are poisons; there is none that is not a poison. The right dose differentiates a poison from a remedy." This is often condensed to: "The dose makes the poison." So, why are we overtly anxious about intoxications?In fact, poisons became a global problem with the industrial revolution. Pesticides, asbestos, occupational chemicals, air pollution, and heavy metal toxicity maintain high priority worldwide, especially in developing countries. Children between 0 and 5 years old are the most vulnerable to both acute and chronic poisonings, while older adults suffer from the chronic effects of chemicals. This book aims to raise awareness about the challenges of poisons, to help clinicians understand current issues in toxicology.
| Author | : Toshiyuki Fukada |
| Publisher | : Springer Nature |
| Total Pages | : 412 |
| Release | : 2019-12-13 |
| Genre | : Medical |
| ISBN | : 9811505578 |
This book, now in an extensively revised second edition, describes the crucial role of zinc signaling in biological processes on a molecular and physiological basis. Global leaders in the field review the latest knowledge, including the very significant advances in understanding that have been achieved since publication of the first edition. Detailed information is provided on all the essentials of zinc signaling, covering molecular aspects and the roles of zinc transporters, the zinc sensing receptor, and metallothioneins. Detection techniques for zinc signals, involving genetically encoded and chemical probes, are also described. The critical contributions of the zinc signal in maintaining health and the adverse consequences of any imbalance in the signal are then thoroughly addressed. Here, readers will find up-to-date information on the significance of the zinc signal in a wide range of conditions, including cardiovascular disorders, neurodegenerative diseases, diabetes, autoimmune diseases, inflammatory conditions, skin disease, osteoarthritis, and cancer. The book will be of value for researchers, clinicians, and advanced students.
| Author | : Ram Prakash |
| Publisher | : M.D. Publications Pvt. Ltd. |
| Total Pages | : 422 |
| Release | : 1998 |
| Genre | : Medical |
| ISBN | : 9788175330764 |
This book has up-to-date literature and research findings on the heavy metals such as, mercury, cobalt, cadmium, managnese, copper, chromium, boron, iron, lead, nickel, selenium, vanadium, zinc, arsenic, silver, gold, etc. The author have discussed their histopathological, biochemical, histochemical and enzymological effects in plants and animals, particularly in liver, kidney, heart, muscles, brain, bones, reproductive organs, intestine, endocrine system, etc.
| Author | : Robert R Crichton |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 336 |
| Release | : 2016-10-18 |
| Genre | : Science |
| ISBN | : 1782623892 |
Metal chelators are emerging as versatile tool with many medical applications. Their versatility allows them to be used in chelation therapy for treating diseases caused by toxic and heavy metal poisoning, chelating agents are capable of binding to toxic metal ions to form complex structures which are easily excreted from the body removing them from intracellular or extracellular spaces. In addition, metal chelators can also be applied as contrast agents in MRI scanning. Metal Chelation in Medicine provides a clear and timely perspective on the role of chelating agents in the management of metal intoxications and storage diseases. Written by leaders in the field of chelators, this publication is at the cutting-edge of the subject. It covers a broad range of topics such as the use of metal chelators in non-invasive assessment of brain iron overload, and the treatment of systemic iron overload and neurodegenerative diseases. As such it is particularly valuable to clinicians treating metal poisonings and metal storage diseases. However, it is also a useful text for researchers, industry professionals and university students with a specific interest in medicinal chemistry, chelation, metal ions, imaging and non-invasive techniques.
| Author | : Hosam El-Din M. Saleh |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 414 |
| Release | : 2018-06-27 |
| Genre | : Technology & Engineering |
| ISBN | : 1789233607 |
Fundamental societal changes resulted from the necessity of people to get organized in mining, transporting, processing, and circulating the heavy metals and their follow-up products, which in consequence resulted in a differentiation of society into diversified professions and even societal strata. Heavy metals are highly demanded technological materials, which drive welfare and progress of the human society, and often play essential metabolic roles. However, their eminent toxicity challenges the field of chemistry, physics, engineering, cleaner production, electronics, metabolomics, botany, biotechnology, and microbiology in an interdisciplinary and cross-sectorial manner. Today, all these scientific disciplines are called to dedicate their efforts in a synergistic way to avoid exposure of heavy metals into the eco- and biosphere, to reliably monitor and quantify heavy metal contamination, and to foster the development of novel strategies to remediate damage caused by heavy metals.
| Author | : David Baker |
| Publisher | : Oxford University Press |
| Total Pages | : 368 |
| Release | : 2012-03-15 |
| Genre | : Medical |
| ISBN | : 9780199652549 |
Essentials of Toxicology for Health Protection is a key handbook and course reader for all health protection professionals. It covers the basics of toxicology and its application to issues of topical concern including contaminated land, water pollution and traditional medicines.
| Author | : Antonella Furini |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 96 |
| Release | : 2012-04-23 |
| Genre | : Science |
| ISBN | : 9400744412 |
This title focuses on the many aspects of the interaction between plants and heavy metals. Not only it describes the effects of heavy metal toxicity on the plant cell and its organs but it also examines the mechanisms that plants adopt to scavenge heavy metals at cellular, physiological, and metabolic level. Plants and Heavy Metals also analyses Hyperaccumulator plants and shows their potential role in phytoremediation technologies in light of the recent research results.
| Author | : Andreas Luch |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 580 |
| Release | : 2012-06-07 |
| Genre | : Medical |
| ISBN | : 3764383402 |
Environmental Toxicology is the third volume of a three-volume set on molecular, clinical and environmental toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals of daily life. By providing intriguing insights far down to the molecular level, this three-volume work covers the entire range of modern toxicology with special emphasis on recent developments and achievements. It is written for students and professionals in medicine, science, public health or engineering who are demanding reliable information on toxic or potentially harmful agents and their adverse effects on the human body.
| Author | : Keith A. Powell |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 374 |
| Release | : 2013-06-29 |
| Genre | : Science |
| ISBN | : 1489909818 |
Proceedings of a symposium held in Canterbury, United Kingdom, April 5-8, 1993.
