Heat Shock Proteins In Neuroscience
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| Author | : Christian Alzheimer |
| Publisher | : Springer |
| Total Pages | : 0 |
| Release | : 2012-11-05 |
| Genre | : Medical |
| ISBN | : 9781461349341 |
Given the very limited capacity of regeneration in the brain, protecting neurons that are on the brink of death is a major challenge for basic and clinical neuroscience, with implications for a broad spectrum of acute and chronic neurological and psychiatric diseases. This book brings together leading experts from neurobiology, neurophysiology, neuropharmacology, neuroimmunology and clinical neuroscience to highlight the most recent milestones in this rapidly evolving field. The book will serve as a reference for both basic neuroscientists and clinicians interested in an authoritative update on the molecular and cellular biology of neuroprotection and its promises for new therapeutic strategies.
| Author | : Alexzander A. A. Asea |
| Publisher | : Springer Nature |
| Total Pages | : 304 |
| Release | : 2019-10-30 |
| Genre | : Science |
| ISBN | : 3030242854 |
The book Heat Shock Proteins in Neuroscience provides the most comprehensive review on contemporary knowledge on the role of HSP in signaling pathways relevant to a number of diseases. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding of Neurological Aspects of HSP; Section II, focuses on Aspects of HSP in Neurodegenerative Diseases and Disorders, Section III, emphasizes the importance of HSP in Multiple Sclerosis; Section IV, reviews critical Aspects of HSP in Alzheimer’s Disease and Section V, gives a comprehensive update of the Development of HSP-Based Therapies for Neurological Disorders. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for starters and professionals in the fields of Neurology and Neurosciences, Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
| Author | : Hari Shanker Sharma |
| Publisher | : Elsevier |
| Total Pages | : 611 |
| Release | : 2011-09-22 |
| Genre | : Science |
| ISBN | : 0080549993 |
The effects of global warming on human health factors with special regards to our brain function are still not well understood. There is an urgent need to expand our knowledge on the effects of hot environment on our brain functions in healthy and in diseased populations. It is still unclear whether infectious events, traumatic injuries, metabolic diseases, carcinogenic events, cardiovascular and respiratory functions will be adversely affected by the rise in global temperature or whether environmental pollutants, such as nanoparticles entered into our body system will produce more damage at high ambient temperatures. This book aims to answer these questions based on recent research carried out by top experts in the field from the USA (11 chapters), Europe (8) chapters), the Middle East (3 chapters), Asia (2 chapters) and Canada (1). These chapters are written in review style and embedded with the author’s new and original data in relation to the current knowledge in the field. The book is highly interesting to the first time readers, beginners and students alike as well as provides in-depth knowledge to the professionals. In addition, prospects for future research and recommendations are clearly indicated in each chapter for future growth of the subject in this highly emerging new discipline. Describes the importance of brain temperature and hyperthermia in disease processes Presents research on the first observations on Nanoparticles that worsen the outcome of hyperthermia Discusses the effects of hyperthermia on the blood-brain and blood-cerebrospinal fluid barriers
| Author | : Alexzander A. A. Asea |
| Publisher | : Springer |
| Total Pages | : 341 |
| Release | : 2016-11-23 |
| Genre | : Science |
| ISBN | : 3319463403 |
Heat Shock Proteins and Plants provides the most up-to-date and concise reviews and progress on the role of heat shock proteins in plant biology, structure and function and is subdivided into chapters focused on Small Plant HSPs (Part I), Larger Plant HSPs (Part II) and HSPs for Therapeutic Gain (Part III). This book is written by eminent leaders and experts from around the world and is an important reference book and a must-read for undergraduate, postgraduate students and researchers in the fields of Agriculture, Botany, Crop Research, Plant Genetics and Biochemistry, Biotechnology, Drug Development and Pharmaceutical Sciences.
| Author | : Stuart K. Calderwood |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 399 |
| Release | : 2007-09-09 |
| Genre | : Medical |
| ISBN | : 1402064012 |
Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.
| Author | : Alexzander A. A. Asea |
| Publisher | : Springer Nature |
| Total Pages | : 359 |
| Release | : 2019-10-31 |
| Genre | : Science |
| ISBN | : 3030231542 |
The book Heat Shock Protein 60 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP60 in human diseases and disorders. Using an integrative approach, the contributors provide a synopsis of novel mechanisms and signal transduction pathways. To enhance the ease of reading and comprehension the book has further been subdivided into various section including; Section I: Biomolecular Aspects of HSP60; Section II: HSP60 and Cancer; Section III: HSP60 and Inflammatory Diseases and Disorders; Section IV: HSP60 and Cardiovascular Diseases and Disorders; Section V: HSP60 and Neurological and Neurosciences; Section VI: Biomolecular Aspects of HSP60; Section VII: HSP60 and Skeletal Muscle Diseases and Disorders; and Section VIII: HSP60 in Human Health. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Neurology & Neuroscience, Oncology, Cardiovascular Disease, Skeletal Muscle Diseases and Disorders, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
| Author | : Institute of Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 448 |
| Release | : 1999-09-15 |
| Genre | : Technology & Engineering |
| ISBN | : 0309172810 |
It is a commonly held belief that athletes, particularly body builders, have greater requirements for dietary protein than sedentary individuals. However, the evidence in support of this contention is controversial. This book is the latest in a series of publications designed to inform both civilian and military scientists and personnel about issues related to nutrition and military service. Among the many other stressors they experience, soldiers face unique nutritional demands during combat. Of particular concern is the role that dietary protein might play in controlling muscle mass and strength, response to injury and infection, and cognitive performance. The first part of the book contains the committee's summary of the workshop, responses to the Army's questions, conclusions, and recommendations. The remainder of the book contains papers contributed by speakers at the workshop on such topics as, the effects of aging and hormones on regulation of muscle mass and function, alterations in protein metabolism due to the stress of injury or infection, the role of individual amino acids, the components of proteins, as neurotransmitters, hormones, and modulators of various physiological processes, and the efficacy and safety considerations associated with dietary supplements aimed at enhancing performance.
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 290 |
| Release | : 2016-02-23 |
| Genre | : Medical |
| ISBN | : 0128024836 |
Hsp90 in Cancer: Beyond the Usual Suspects, the latest volume in the Advances in Cancer Research series, focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins and discusses some of the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression. - Focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins - Highlights the rapidly evolving understanding of the fundamental roles of Hsp90 in cancer biology - Discusses the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression
| Author | : Alexzander A. A. Asea |
| Publisher | : Springer Nature |
| Total Pages | : 599 |
| Release | : 2019-11-04 |
| Genre | : Science |
| ISBN | : 3030231585 |
The book Heat Shock Protein 90 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP90. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, previously unknown signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding Oncogenic Aspects of HSP90; Section II, focuses on Bimolecular Aspects of HSP90; Section III, emphasizes and HSP90 in Natural Products Development and Section IV; give the most up to date reviews on Clinical Aspects of HSP90. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for starters and professionals in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Natural Products, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
| Author | : Robert M. Tanguay |
| Publisher | : Springer |
| Total Pages | : 603 |
| Release | : 2015-06-15 |
| Genre | : Medical |
| ISBN | : 331916077X |
Based upon a workshop entitled “The Small HSP World” held in Québec 2-5 October 2014. Twenty-five scientists provided chapters for the book. The chapters are from the best scientists currently working in this field. These colleagues include Arrigo, Benesch, Benjamin, Buchner-Haslbeck-Weinkauf, Benndorf, Boelens, Carra, Chang, Currie, Ecroyd, Emanuelsson, Fu, Garrido, Golenhofen, Gusev, Hightower, Kampinga, Lavoie, MacRae, Quinlan, Tanguay, Vierling, Vigh, Weeks and Wu. Briefly, the book starts with the structure of small heat shock proteins, moving to their functions and finishing with their involvement in diseases. Although this is quite broad, the structural aspect will be the unifying theme of the book.
