Molecular Basis of Health and Disease

Molecular Basis of Health and Disease
Author: Undurti N. Das
Publisher: Springer Science & Business Media
Total Pages: 591
Release: 2011-04-02
Genre: Medical
ISBN: 940070495X

The book describes how the balance between pro- and anti-inflammatory molecules is related to health and disease. It is suggested that many diseases are initiated and their progress is influenced by inflammatory molecules and a decrease in the production and/or action of anti-inflammatory molecules and this imbalance between pro- and anti-inflammatory molecules seems to have been initiated in the perinatal period. This implies that strategies to prevent and manage various adult diseases should start in the perinatal period. An alteration in the metaolism of essential fatty acids and their anti-inflammatory molecules such as lipoxins, resolvins, protecitns, maresins and nitrolipids seems to play a major role in the pathobiology of several adult diseases. Based on these concepts, novel therapeutic approaches in the management of insulin resistance, obesity, type 2 diabetes mellitus, metabolic syndrome, cancer, lupus, rheumatoid arthritis and other auto-immune diseases are presented. Based on all these evidences, a unified concept that several adult diseases are due to an alteration in the balance between pro- and anti-inflammatory molecules is discussed and novel methods of their management are presented.

The Future of Public Health

The Future of Public Health
Author: Committee for the Study of the Future of Public Health
Publisher: National Academies Press
Total Pages: 240
Release: 1988-01-15
Genre: Medical
ISBN: 0309581907

"The Nation has lost sight of its public health goals and has allowed the system of public health to fall into 'disarray'," from The Future of Public Health. This startling book contains proposals for ensuring that public health service programs are efficient and effective enough to deal not only with the topics of today, but also with those of tomorrow. In addition, the authors make recommendations for core functions in public health assessment, policy development, and service assurances, and identify the level of government--federal, state, and local--at which these functions would best be handled.

Disease Control Priorities in Developing Countries

Disease Control Priorities in Developing Countries
Author: Dean T. Jamison
Publisher: World Bank Publications
Total Pages: 1449
Release: 2006-04-02
Genre: Medical
ISBN: 0821361805

Based on careful analysis of burden of disease and the costs ofinterventions, this second edition of 'Disease Control Priorities in Developing Countries, 2nd edition' highlights achievable priorities; measures progresstoward providing efficient, equitable care; promotes cost-effectiveinterventions to targeted populations; and encourages integrated effortsto optimize health. Nearly 500 experts - scientists, epidemiologists, health economists,academicians, and public health practitioners - from around the worldcontributed to the data sources and methodologies, and identifiedchallenges and priorities, resulting in this integrated, comprehensivereference volume on the state of health in developing countries.

The Biopsychosocial Model of Health and Disease

The Biopsychosocial Model of Health and Disease
Author: Derek Bolton
Publisher: Springer
Total Pages: 157
Release: 2019-03-28
Genre: Psychology
ISBN: 3030118991

This open access book is a systematic update of the philosophical and scientific foundations of the biopsychosocial model of health, disease and healthcare. First proposed by George Engel 40 years ago, the Biopsychosocial Model is much cited in healthcare settings worldwide, but has been increasingly criticised for being vague, lacking in content, and in need of reworking in the light of recent developments. The book confronts the rapid changes to psychological science, neuroscience, healthcare, and philosophy that have occurred since the model was first proposed and addresses key issues such as the model’s scientific basis, clinical utility, and philosophical coherence. The authors conceptualise biology and the psychosocial as in the same ontological space, interlinked by systems of communication-based regulatory control which constitute a new kind of causation. These are distinguished from physical and chemical laws, most clearly because they can break down, thus providing the basis for difference between health and disease. This work offers an urgent update to the model’s scientific and philosophical foundations, providing a new and coherent account of causal interactions between the biological, the psychological and social.

Developmental Origins of Health and Disease

Developmental Origins of Health and Disease
Author: Peter Gluckman
Publisher: Cambridge University Press
Total Pages: 542
Release: 2006-04-20
Genre: Medical
ISBN: 9780521847438

This landmark publication provides the first definitive account of how and why subtle influences on the fetus and during early life can have such profound consequences for adult health and diseases. Although the epidemiological evidence for this link has long proved compelling, it is only much more recently that the scientific and physiological basis has begun to be studied in depth and fully understood. The compilation, written by many of the world's leading experts in this exciting field, summarizes these scientific and clinical advances.

Improving Health in the Community

Improving Health in the Community
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 497
Release: 1997-05-21
Genre: Medical
ISBN: 0309055342

How do communities protect and improve the health of their populations? Health care is part of the answer but so are environmental protections, social and educational services, adequate nutrition, and a host of other activities. With concern over funding constraints, making sure such activities are efficient and effective is becoming a high priority. Improving Health in the Community explains how population-based performance monitoring programs can help communities point their efforts in the right direction. Within a broad definition of community health, the committee addresses factors surrounding the implementation of performance monitoring and explores the "why" and "how to" of establishing mechanisms to monitor the performance of those who can influence community health. The book offers a policy framework, applies a multidimensional model of the determinants of health, and provides sets of prototype performance indicators for specific health issues. Improving Health in the Community presents an attainable vision of a process that can achieve community-wide health benefits.

Health, Illness and Disease

Health, Illness and Disease
Author: Havi Carel
Publisher: Routledge
Total Pages: 268
Release: 2014-09-11
Genre: Philosophy
ISBN: 1317544862

What counts as health or ill health? How do we deal with the fallibility of our own bodies? Should illness and disease be considered simply in biological terms, or should considerations of its emotional impact dictate our treatment of it? Our understanding of health and illness had become increasingly more complex in the modern world, as we are able to use medicine not only to fight disease but to control other aspects of our bodies, whether mood, blood pressure, or cholesterol. This collection of essays foregrounds the concepts of health and illness and patient experience within the philosophy of medicine, reflecting on the relationship between the ill person and society. Mental illness is considered alongside physical disease, and the important ramifications of society's differentiation between the two are brought to light. Health, Illness and Disease is a significant contribution to shaping the parameters of the evolving field of philosophy of medicine and will be of interest to medical practitioners and policy-makers as well as philosophers of science and ethicists.

The Gut Microbiome in Health and Disease

The Gut Microbiome in Health and Disease
Author: Dirk Haller
Publisher: Springer
Total Pages: 355
Release: 2018-07-27
Genre: Medical
ISBN: 3319905457

The book provides an overview on how the gut microbiome contributes to human health. The readers will get profound knowledge on the connection between intestinal microbiota and immune defense systems. The tools of choice to study the ecology of these highly-specialized microorganism communities such as high-throughput sequencing and metagenomic mining will be presented. In addition the most common diseases associated to the composition of the gut flora are discussed in detail. The book will address researchers, clinicians and advanced students working in biomedicine, microbiology and immunology.

Executive Functions in Health and Disease

Executive Functions in Health and Disease
Author: Elkhonon Goldberg
Publisher: Academic Press
Total Pages: 614
Release: 2017-07-04
Genre: Psychology
ISBN: 0128037059

Executive Functions in Health and Disease provides a comprehensive review of both healthy and disordered executive function. It discusses what executive functions are, what parts of the brain are involved, what happens when they go awry in cases of dementia, ADHD, psychiatric disorders, traumatic injury, developmental disorders, cutting edge methods for studying executive functions and therapies for treating executive function disorders. It will appeal to neuropsychologists, clinical psychologists, neuroscientists and researchers in cognitive psychology. - Encompasses healthy executive functioning as well as dysfunction - Identifies prefrontal cortex and other brain areas associated with executive functions - Reviews methods and tools used in executive function research - Explores executive dysfunction in dementia, ADHD, PTSD, TBI, developmental and psychiatric disorders - Discusses executive function research expansion in social and affective neuroscience, neuroeconomics, aging and criminology - Includes color neuroimages showing executive function brain activity

Polyphenols in Human Health and Disease

Polyphenols in Human Health and Disease
Author: Ronald Ross Watson
Publisher: Academic Press
Total Pages: 1504
Release: 2013-10-26
Genre: Science
ISBN: 012398467X

Polyphenols in Human Health and Disease documents antioxidant actions of polyphenols in protection of cells and cell organelles, critical for understanding their health-promoting actions to help the dietary supplement industry. The book begins by describing the fundamentals of absorption, metabolism and bioavailability of polyphenols, as well as the effect of microbes on polyphenol structure and function and toxicity. It then examines the role of polyphenols in the treatment of chronic disease, including vascular and cardiac health, obesity and diabetes therapy, cancer treatment and prevention, and more. - Explores neuronal protection by polyphenol metabolites and their application to medical care - Defines modulation of enzyme actions to help researchers see and study polyphenols' mechanisms of action, leading to clinical applications - Includes insights on polyphenols in brain and neurological functions to apply them to the wide range of aging diseases