This book explores new methods and techniques for research about merchant networks and maritime routes of trade during the First Global Age through the use of Geographic Information Systems (GIS) as a tool to visualize the formation of trading systems, database management, cartography and spatio-temporal analysis in Historical GIS. In doing so, the book focuses on key issues in understanding the birth of the so-called First Global Age (16th to 18th centuries): the integration of spatial economies; the regionalization of markets; the organization of maritime trade routes; and the evolution of self-organizing networks of merchants, producers, communities, and other social agents during the age of expansion. The essays collected here deal with relevant information about historical problems including maritime connections, the organization of oceanic trade and the use of digital cartography and metric analysis of old maps, and social network analysis – commercial networks involved a high level of cooperation and served to move goods and people within a highly open system over an expanding geographic space.