Principles of Safety Pharmacology

Principles of Safety Pharmacology
Author: Michael K. Pugsley
Publisher: Springer
Total Pages: 477
Release: 2015-06-19
Genre: Medical
ISBN: 366246943X

This book illustrates, in a comprehensive manner, the most current areas of importance to Safety Pharmacology, a burgeoning unique pharmacological discipline with important ties to academia, industry and regulatory authorities. It provides readers with a definitive collection of topics containing essential information on the latest industry guidelines and overviews current and breakthrough topics in both functional and molecular pharmacology. An additional novelty of the book is that it constitutes academic, pharmaceutical and biotechnology perspectives for Safety Pharmacology issues. Each chapter is written by an expert in the area and includes not only a fundamental background regarding the topic but also detailed descriptions of currently accepted, validated models and methods as well as innovative methodologies used in drug discovery.

Behavioral Neurobiology of Psychedelic Drugs

Behavioral Neurobiology of Psychedelic Drugs
Author: Adam L. Halberstadt
Publisher: Springer
Total Pages: 434
Release: 2018-03-27
Genre: Medical
ISBN: 3662558807

This volume brings together the latest basic and clinical research examining the effects and underlying mechanisms of psychedelic drugs. Examples of drugs within this group include LSD, psilocybin, and mescaline. Despite their structural differences, these compounds produce remarkably similar experiences in humans and share a common mechanism of action. Commonalities among the substances in this family are addressed both at the clinical and phenomenological level and at the basic neurobiological mechanism level. To the extent possible, contributions relate the clinical and preclinical findings to one another across species. The volume addresses both the risks associated with the use of these drugs and the potential medical benefits that might be associated with these and related compounds.

Fundamentals of Electrochemical Deposition

Fundamentals of Electrochemical Deposition
Author: Milan Paunovic
Publisher: John Wiley & Sons
Total Pages: 388
Release: 2006-08-11
Genre: Science
ISBN: 047000939X

Excellent teaching and resource material . . . it is concise, coherently structured, and easy to read . . . highly recommended for students, engineers, and researchers in all related fields." -Corrosion on the First Edition of Fundamentals of Electrochemical Deposition From computer hardware to automobiles, medical diagnostics to aerospace, electrochemical deposition plays a crucial role in an array of key industries. Fundamentals of Electrochemical Deposition, Second Edition is a comprehensive introduction to one of today's most exciting and rapidly evolving fields of practical knowledge. The most authoritative introduction to the field so far, the book presents detailed coverage of the full range of electrochemical deposition processes and technologies, including: * Metal-solution interphase * Charge transfer across an interphase * Formation of an equilibrium electrode potential * Nucleation and growth of thin films * Kinetics and mechanisms of electrodeposition * Electroless deposition * In situ characterization of deposition processes * Structure and properties of deposits * Multilayered and composite thin films * Interdiffusion in thin film * Applications in the semiconductor industry and the field of medicine This new edition updates the prior edition to address the new developments in the science and its applications, with new chapters on innovative applications of electrochemical deposition in semiconductor technology, magnetism and microelectronics, and medical instrumentation. Added coverage includes such topics as binding energy, nanoclusters, atomic force, and scanning tunneling microscopy.Example problems at the end of chapters and other features clarify and improve understanding of the material. Written by an author team with extensive experience in both industry and academe, this reference and text provides a well-rounded introduction to the field for students, as well as a means for professional chemists, engineers, and technicians to expand and sharpen their skills in using the technology.

Cochlear Implants

Cochlear Implants
Author: Graeme Clark
Publisher: Springer Science & Business Media
Total Pages: 864
Release: 2006-04-18
Genre: Medical
ISBN: 0387215506

The cochlear implant is a device that bypasses a nonfunctional inner ear and stimulates the auditory nerve directly. Written by the "father" of the multi-electrode implant, this comprehensive text and reference gives an account of the principles underlying cochlear implants and their clinical application. For the clinician, the book will provide guidance in the treatment of patients; for the engineer and researcher it will provide the background for further research; and for the student, it will provide a through understanding of the subject.

Stem Cells & Regenerative Medicine

Stem Cells & Regenerative Medicine
Author: Krishnarao Appasani
Publisher: Springer Science & Business Media
Total Pages: 632
Release: 2010-11-01
Genre: Science
ISBN: 1607618605

Defined as, “The science about the development of an embryo from the fertilization of the ovum to the fetus stage,” embryology has been a mainstay at universities throughout the world for many years. Throughout the last century, embryology became overshadowed by experimental-based genetics and cell biology, transforming the field into developmental biology, which replaced embryology in Biology departments in many universities. Major contributions in this young century in the fields of molecular biology, biochemistry and genomics were integrated with both embryology and developmental biology to provide an understanding of the molecular portrait of a “development cell.” That new integrated approach is known as stem-cell biology; it is an understanding of the embryology and development together at the molecular level using engineering, imaging and cell culture principles, and it is at the heart of this seminal book. Stem Cells and Regenerative Medicine: From Molecular Embryology to Tissue Engineering is completely devoted to the basic developmental, cellular and molecular biological aspects of stem cells as well as their clinical applications in tissue engineering and regenerative medicine. It focuses on the basic biology of embryonic and cancer cells plus their key involvement in self-renewal, muscle repair, epigenetic processes, and therapeutic applications. In addition, it covers other key relevant topics such as nuclear reprogramming induced pluripotency and stem cell culture techniques using novel biomaterials. A thorough introduction to stem-cell biology, this reference is aimed at graduate students, post-docs, and professors as well as executives and scientists in biotech and pharmaceutical companies.

Computational Intelligence Systems and Applications

Computational Intelligence Systems and Applications
Author: Marian B. Gorzalczany
Publisher: Springer Science & Business Media
Total Pages: 384
Release: 2001-12-14
Genre: Computers
ISBN: 9783790814392

Traditional Artificial Intelligence (AI) systems adopted symbolic processing as their main paradigm. Symbolic AI systems have proved effective in handling problems characterized by exact and complete knowledge representation. Unfortunately, these systems have very little power in dealing with imprecise, uncertain and incomplete data and information which significantly contribute to the description of many real world problems, both physical systems and processes as well as mechanisms of decision making. Moreover, there are many situations where the expert domain knowledge (the basis for many symbolic AI systems) is not sufficient for the design of intelligent systems, due to incompleteness of the existing knowledge, problems caused by different biases of human experts, difficulties in forming rules, etc. In general, problem knowledge for solving a given problem can consist of an explicit knowledge (e.g., heuristic rules provided by a domain an implicit, hidden knowledge "buried" in past-experience expert) and numerical data. A study of huge amounts of these data (collected in databases) and the synthesizing of the knowledge "encoded" in them (also referred to as knowledge discovery in data or data mining), can significantly improve the performance of the intelligent systems designed.

Trusted Criminals

Trusted Criminals
Author: David O. Friedrichs
Publisher: Wadsworth Publishing Company
Total Pages: 484
Release: 2007
Genre: Education
ISBN:

TRUSTED CRIMINALS: WHITE COLLAR CRIME IN CONTEMPORARY SOCIETY is a comprehensive guide that covers topics ranging from the problems involved in studying white collar crimes to the principal focus of the crimes to the character of the legal and criminal justice response to the crime.

Aesthetic Applications of Intense Pulsed Light

Aesthetic Applications of Intense Pulsed Light
Author: Lucian Fodor
Publisher: Springer Science & Business Media
Total Pages: 148
Release: 2010-10-14
Genre: Medical
ISBN: 1849964564

The book is structured into eight chapters: 1. Skin anatomy. This chapter is intended to describe the pertinent anatomy related to IPL applications. In addition to the described main structural elements of the skin, the chapter has important points about skin aging and histological aspects which gives the reader a better understanding of the etiology of skin lesions and the need for Intense Pulsed Light (IPL) treatment. 2. Light-tissue interaction. This chapter describes the interaction between IPL and different skin structures. Target skin structures (chromophores) are described in detail. The results of this interaction are detailed as being important to understanding the goals and principles of IPL treatment. 3. IPL safety and legal issues. This chapter describes the needs of the environment for a safe treatment. The necessary equipment and things to avoid pitfalls which may lead to lawsuits are detailed. Several aspects of IPL legal issues are also described: how to avoid medical liabilities and how to manage them are also included in this chapter. 4. Patient selection. This chapter describes the pearls and pitfalls in selecting patients for IPL treatment. This is not an easy task and proper patient selection is extremely important to have satisfied patients. Problematic patient types are also described here. 5. Skin rejuvenation. This chapter starts with a description of skin aging. Intrinsic and extrinsic mechanisms are detailed. The most common skin lesions related to aging that can benefit from IPL treatment for rejuvenation are detailed. The chapter continues with treatment protocols which describe strategies for achieving optimal results. A review of the literature is included, presenting the treatment parameters of different studies and their results. 6. Hair removal. This chapter starts with a description of the hair follicle cycle, hair types and important structures for treatment. Treatment strategies are emphasized and detailed, starting from choosing the right parameters to post-treatment recommendations. A literature review is presented regarding treatment parameters and results according to different authors. 7. Vascular lesions treatment. This chapter describes the types of vascular lesions that can benefit from IPL treatment. The treatment protocol is emphasized and all the steps for performing this application are described in detail. A literature review is presented and different results are compared regarding treatment parameters. 8. Complications. It is inevitable that any medical treatment can end with complications. The possible complications of the most common IPL applications (skin rejuvenation, hair removal, pigmented and vascular lesion treatment) are detailed. The way to avoid them and how to handle them is also described. At the end of each chapter, there is a section on the practical points highlighting the most important points of the chapter. An extensive literature review of this technology is presented alongside numerous illustrations, tables and color pictures. The book will benefit any doctor or healthcare professional who uses IPL for cosmetic purposes, such as plastic surgeons, dermatologists, ophthalmologists, maxillofacial surgeons and otolaryngologists dealing with aesthetics of the face, as well as residents interested in learning the subject.

Beyond Brain Death

Beyond Brain Death
Author: M. Potts
Publisher: Springer Science & Business Media
Total Pages: 408
Release: 2006-04-11
Genre: Philosophy
ISBN: 0306468824

Beyond Brain Death offers a provocative challenge to one of the most widely accepted conclusions of contemporary bioethics: the position that brain death marks the death of the human person. Eleven chapters by physicians, philosophers, and theologians present the case against brain-based criteria for human death. Each author believes that this position calls into question the moral acceptability of the transplantation of unpaired vital organs from brain-dead patients who have continuing function of the circulatory system. One strength of the book is its international approach to the question: contributors are from the United States, the United Kingdom, Liechtenstein, and Japan. This book will appeal to a wide audience, including physicians and other health care professionals, philosophers, theologians, medical sociologists, and social workers.