Personalized Medicine in Oncology

Personalized Medicine in Oncology
Author: Ari VanderWalde
Publisher:
Total Pages: 174
Release: 2022
Genre:
ISBN: 9783036528205

Nowhere is the explosion in comprehensive genomic testing more evident than in oncology. Multiple consensus guidelines now recommend molecular testing as the standard of care for most metastatic tumors. To aid in the advancement of this rapidly changing field, we intend this Special Issue of JPM to focus on technical developments in the genomic profiling of cancer, detail promising somatic alterations that either are, or have a high likelihood of being, relevant in the near future, and to address issues related to the pricing and value of these tests.The last few years have seen the cost of molecular testing decrease by orders of magnitude. In 2018, we saw the first “site-agnostic” drug approvals in cancer (for microsatellite unstable cancer (PD-1 inhibitors) and NTRK-fusions (TRK inhibitors)). Research on targetable mutations, determination of genetic “signatures” that can use multiple individual genes/pathways, development of targeted therapy, and insight into the value of new technology remains at the cutting edge of research in this field. We are soliciting papers that present new technologies to assess predictive biomarkers in cancer, original research (pre-clinical or clinical) that demonstrates promise for particular targeted therapies in cancer, and articles that explore the clinical and financial impacts of this paradigmatic shift in cancer diagnostics and treatment.

Toward Precision Medicine

Toward Precision Medicine
Author: National Research Council
Publisher: National Academies Press
Total Pages: 142
Release: 2012-01-16
Genre: Medical
ISBN: 0309222222

Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.

Precision Medicine in Gastrointestinal Cancers

Precision Medicine in Gastrointestinal Cancers
Author: Afsaneh Barzi
Publisher: Frontiers Media SA
Total Pages: 293
Release: 2023-09-01
Genre: Medical
ISBN: 283253290X

Precision medicine is the main emphasis in healthcare after recognizing the importance to integrate the clinical data with the molecular data of a specific disease. The term was first introduced in 2015 in which the Precision Medicine Initiative was initiated with the final aim to provide targeted therapy with high efficacy and less toxicity. Precision medicine plays an increasingly important in gastrointestinal cancers. Gastrointestinal cancers are divided into the upper (esophagus, stomach) and lower part (hepatobiliary and colon) of the gastrointestinal system. We would like to explore the latest era of integrative therapeutic target in gastrointestinal cancers taking into consideration of various aetiologies including genetic and exposome (dietary factors, microbial, hormonal, environmental insults) and their interactions with the host microenvironment.

Tumor Organoids

Tumor Organoids
Author: Shay Soker
Publisher: Humana Press
Total Pages: 225
Release: 2017-10-20
Genre: Medical
ISBN: 3319605119

Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

Translational Research and Onco-Omics Applications in the Era of Cancer Personal Genomics

Translational Research and Onco-Omics Applications in the Era of Cancer Personal Genomics
Author: Erika Ruiz-Garcia
Publisher: Springer Nature
Total Pages: 171
Release: 2019-11-11
Genre: Science
ISBN: 3030241009

Being a complex disease that affects millions of people world over, cancer research has assumed great significance. Translational cancer research transforms scientific discoveries in the laboratory into clinical application to reduce incidence of cancer, morbidity and mortality. On the other hand, personalized medicine in cancer is the concept that selection of a treatment should be tailored according to the individual patient’s specific genomic characteristics, including mutations, chromosomal aberrations, protein interactions, and SNPs, and even more, taking into account the inmume system, the metabolism and maybe in the next future also the microbiome.

Precision Medicine in Oncology

Precision Medicine in Oncology
Author: Bulent Aydogan
Publisher: John Wiley & Sons
Total Pages: 288
Release: 2020-11-02
Genre: Medical
ISBN: 1119432448

A FRESH EXAMINATION OF PRECISION MEDICINE'S INCREASINGLY PROMINENT ROLE IN THE FIELD OF ONCOLOGY Precision medicine takes into account each patient's specific characteristics and requirements to arrive at treatment plans that are optimized towards the best possible outcome. As the field of oncology continues to advance, this tailored approach is becoming more and more prevalent, channelling data on genomics, proteomics, metabolomics and other areas into new and innovative methods of practice. Precision Medicine in Oncology draws together the essential research driving the field forward, providing oncology clinicians and trainees alike with an illuminating overview of the technology and thinking behind the breakthroughs currently being made. Topics covered include: Biologically-guided radiation therapy Informatics for precision medicine Molecular imaging Biomarkers for treatment assessment Big data Nanoplatforms Casting a spotlight on this emerging knowledge base and its impact upon the management of tumors, Precision Medicine in Oncology opens up new possibilities and ways of working – not only for oncologists, but also for molecular biologists, radiologists, medical geneticists, and others.

Surgical Oncology

Surgical Oncology
Author: David L Bartlett
Publisher: JP Medical Ltd
Total Pages: 628
Release: 2011-03-31
Genre: Medical
ISBN: 9350250519

Written by world renowned experts in surgical oncology, this book examines various types of cancer and their treatment options based on 'Level of Evidence' tables. The text provides an up-to-date review of the knowledge required by surgical oncologists, from basic biology, to the application of regional chemotherapy, minimally invasive surgery and palliative care.

Financing Health Services in Developing Countries

Financing Health Services in Developing Countries
Author: John S. Akin
Publisher: World Bank Publications
Total Pages: 104
Release: 1987-01-01
Genre: Business & Economics
ISBN: 9780821309001

This report discusses several different approaches that support reforming health care services in developing countries. For some time now, health care services have been supported by government funds. As demands for improving health care services continue to increase additional demands will be placed on governments to respond. This, however, will not be easy. Slow economic growth and record budget deficits in the 1980's have forced reductions in public spending. Alternative approaches to finance health care services are needed. Such possible changes could involve: decentralization of federal government involvement; the promotion of nongovernment involvement; the imposition of user fees; and, establishing health insurance. Finally, the role of the Bank in pursuing new financing strategies is discussed.

Gastrointestinal Cancers:

Gastrointestinal Cancers:
Author: Prateek Sharma
Publisher: JP Medical Ltd
Total Pages: 179
Release: 2012-12-30
Genre: Medical
ISBN: 9350258935

This book is a concise guide to gastrointestinal cancers, focussing specifically on endoscopic imaging and treatment. Each chapter discusses the different approaches for endoscopic diagnosis, looking at the etiology, epidemiology, endoscopic techniques and role of endoscopic interventions for all major types of gastrointestinal cancer. Written by a renowned author and editor team from the UK, Europe, USA and Asia this manual includes nearly 200 colour images and illustrations. Also included are two video DVDs of thirteen different endoscopic procedures. Key Features Concise guide to endoscopic imaging, diagnosis and treatment of major gastrointestinal cancers Renowned author and editor team from the UK, Europe, USA and Asia Nearly 200 colour images and illustrations Includes video DVDs of various endoscopic procedures