From Signal Transduction To Protein Toxins A Narrative Review About Milestones On The Research Route Of C Difficile Toxins
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| Author | : National Academies of Sciences, Engineering, and Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 427 |
| Release | : 2020-04-24 |
| Genre | : Medical |
| ISBN | : 0309672104 |
Among the many who serve in the United States Armed Forces and who are deployed to distant locations around the world, myriad health threats are encountered. In addition to those associated with the disruption of their home life and potential for combat, they may face distinctive disease threats that are specific to the locations to which they are deployed. U.S. forces have been deployed many times over the years to areas in which malaria is endemic, including in parts of Afghanistan and Iraq. Department of Defense (DoD) policy requires that antimalarial drugs be issued and regimens adhered to for deployments to malaria-endemic areas. Policies directing which should be used as first and as second-line agents have evolved over time based on new data regarding adverse events or precautions for specific underlying health conditions, areas of deployment, and other operational factors At the request of the Veterans Administration, Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis assesses the scientific evidence regarding the potential for long-term health effects resulting from the use of antimalarial drugs that were approved by FDA or used by U.S. service members for malaria prophylaxis, with a focus on mefloquine, tafenoquine, and other antimalarial drugs that have been used by DoD in the past 25 years. This report offers conclusions based on available evidence regarding associations of persistent or latent adverse events.
| Author | : Institute of Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 570 |
| Release | : 2011-12-30 |
| Genre | : Science |
| ISBN | : 0309219396 |
Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.
| Author | : Yehuda Gutman |
| Publisher | : CRC Press |
| Total Pages | : 520 |
| Release | : 1997-05-22 |
| Genre | : Science |
| ISBN | : 9789057020780 |
Of the multitude of toxins known and the enormous variety of effects they cause, of particular interest are those that influence signal transduction. Intercellular communication by chemical signals is essential for the functioning of multicellular organisms. Many toxins exert their biological effects by interfering with the signal transduction initiated by these chemicals (hormones, transmitters, growth factors, and other mediators). Up-to-date information is provided by outstanding experts, who discuss the molecular mechanisms involved in the action of many toxins, as well as the use of toxins as informative tools with which to study signal transduction and their potential therapeutic usage. This volume contains useful information for the experimentalist interested in toxins or in signal transduction, as well as for the reader interested in gaining a comprehensive overview of the field. The Cellular and Molecular Mechanisms of Toxin Action series will include monographs on signal transduction, secretory systems, cytoskeleton, selective neurotoxicity of natural, recombinant and chimeric toxins giving a broader emphasis on the mechanism of action, structure-function relationship, and use of toxins as research tools and their therapeutic applications.
| Author | : Alison Fiander |
| Publisher | : Cambridge University Press |
| Total Pages | : 557 |
| Release | : 2016-10-13 |
| Genre | : Education |
| ISBN | : 1107667135 |
A fully updated and illustrated handbook providing comprehensive coverage of all curriculum areas covered by the MRCOG Part 1 examination.
| Author | : Leslie Neal-Boylan |
| Publisher | : John Wiley & Sons |
| Total Pages | : 432 |
| Release | : 2011-11-28 |
| Genre | : Medical |
| ISBN | : 1118277856 |
Clinical Case Studies for the Family Nurse Practitioner is a key resource for advanced practice nurses and graduate students seeking to test their skills in assessing, diagnosing, and managing cases in family and primary care. Composed of more than 70 cases ranging from common to unique, the book compiles years of experience from experts in the field. It is organized chronologically, presenting cases from neonatal to geriatric care in a standard approach built on the SOAP format. This includes differential diagnosis and a series of critical thinking questions ideal for self-assessment or classroom use.
| Author | : Marie Boltz, PhD, RN, GNP-BC, FGSA, FAAN |
| Publisher | : Springer Publishing Company |
| Total Pages | : 751 |
| Release | : 2016-03-28 |
| Genre | : Medical |
| ISBN | : 0826171672 |
This new edition of one of the premier references for geriatric nurses in hospital, long-term, and community settings delivers current guidelines, real-life case studies, and evidence-based protocols developed by master educators and practitioners. With a focus on improving quality of care, cost-effectiveness, and outcome, the fifth edition is updated to provide the most current information about care of common clinical conditions and issues in older patients. Several new expert contributors present current guidelines about hip fractures, frailty, perioperative and postoperative care, palliative care, and senior-friendly emergency departments. Additionally, chapters have been reorganized to enhance logical flow of content and easy information retrieval. Protocols, systematically tested by more than 300 participating NICHE (Nurses Improving Care for Health system Elders) hospitals‚ are organized in a consistent format and include an overview, evidence-based assessment and intervention strategies, and an illustrative case study with discussion. Additionally, protocols are embedded within chapter text, providing the context and detailed evidence for each. Chapter objectives, annotated references,and evidence ratings for each protocol are provided along with resources for additional study. New to the Fifth Edition: Reorganized to enhance logical flow of information and ease of use Updated and revised Includes new contributions from expert educators and practitioners Provides new chapters on perioperative and postoperative care, general surgical care, care of hip fracture, palliative care, and the senior-friendly emergency department Key Features: Includes PowerPoints and a test bank for instructors Delivers evidence-based, current guidelines and protocols for care of common clinical conditions in the older person Illustrates the application of clinical protocols to real-life practice through case studies and discussion Edited by nationally known geriatric leaders who are endorsed by the Hartford Institute for Geriatric Nursing and NICHE Written for nursing students, nurse leaders, and practitioners at all levels, including those in specialty roles
| Author | : Uwe B. Sleytr |
| Publisher | : Springer |
| Total Pages | : 193 |
| Release | : 2011-12-16 |
| Genre | : Science |
| ISBN | : 9783642735394 |
Crystalline surface layers (S-layers) represent an almost universal feature of archaebacterial cell envelopes and can be found in gram-positive and gram-negative eubacterial species from nearly all phylogenetic branches. S-layers consist of a single protein- or glycoprotein species and thus can be considered as one of the most primitive membrane structures developed during evolution. Prokaryotes carrying S-layers are ubiquitously found in every part of the biosphere. This supports the concept of a general supramolecular "porous crystalline surface layer" fulfilling a broad spectrum of functions which are strongly dependent on the particular environmental and ecological conditions. Their structural simplicity makes S-layers a suitable model for analyzing structure-function relationships as well as dynamic aspects of membrane morphogenesis.
| Author | : B. Koletzko |
| Publisher | : Karger Medical and Scientific Publishers |
| Total Pages | : 349 |
| Release | : 2015-04-17 |
| Genre | : Medical |
| ISBN | : 3318026913 |
There is no other time in life when the provision of adequate and balanced nutrition is of greater importance than during infancy and childhood. During this dynamic phase characterized by rapid growth, development and developmental plasticity, a sufficient amount and appropriate composition of nutrients both in health and disease are of key importance for growth, functional outcomes such as cognition and immune response, and the metabolic programming of long-term health and well-being. This compact reference text provides concise information to readers who seek quick guidance on practical issues in the nutrition of infants, children and adolescents. After the success of the first edition, which sold more than 50'000 copies in several languages, the editors prepared this thoroughly revised and updated second edition which focuses again on nutritional challenges in both affluent and poor populations around the world. Serving as a practical reference guide, this book will contribute to further improving the quality of feeding of healthy infants and children, as well as enhancing the standards of nutritional care in sick children.
| Author | : David Byrom |
| Publisher | : Springer |
| Total Pages | : 356 |
| Release | : 1991-06-18 |
| Genre | : Science |
| ISBN | : 1349111678 |
Biomaterials are produced from biological material and are used for their physical characteristics. This book looks at the range of biomaterials and their applications which range from the use of polysaccharides as thickening agents to the use of proteins as fibres and adhesives.
| Author | : Vassil St. Georgiev |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 769 |
| Release | : 2009-07-06 |
| Genre | : Medical |
| ISBN | : 1603272976 |
National Institute of Allergy and Infectious Diseases, NIH: Volume 2: Impact on Global Health covers the scientific aspects of the entire portfolio of NIAID, including microbiology and infectious disease, HIV/AIDS, and immunology and vaccines. All major diseases and the relevant immunology and vaccine development are described in detail. In addition, all major NIAID programs, initiatives, and clinical trials are discussed and illustrate the global involvement of NIAID in biomedical research and its impact on public health worldwide. By providing this information, the global scientific community will be able to access and benefit from these programs and initiatives.
