From Ecology to Cancer Biology and Back Again
| Author | : Frederick R. Adler |
| Publisher | : Frontiers Media SA |
| Total Pages | : 259 |
| Release | : 2022-03-08 |
| Genre | : Science |
| ISBN | : 2889746151 |
From Ecology To Cancer Biology And Back Again
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The Cheating Cell
| Author | : Athena Aktipis |
| Publisher | : Princeton University Press |
| Total Pages | : 256 |
| Release | : 2020-03-24 |
| Genre | : Medical |
| ISBN | : 0691163847 |
A fundamental and groundbreaking reassessment of how we view and manage cancer When we think of the forces driving cancer, we don’t necessarily think of evolution. But evolution and cancer are closely linked because the historical processes that created life also created cancer. The Cheating Cell delves into this extraordinary relationship, and shows that by understanding cancer’s evolutionary origins, researchers can come up with more effective, revolutionary treatments. Athena Aktipis goes back billions of years to explore when unicellular forms became multicellular organisms. Within these bodies of cooperating cells, cheating ones arose, overusing resources and replicating out of control, giving rise to cancer. Aktipis illustrates how evolution has paved the way for cancer’s ubiquity, and why it will exist as long as multicellular life does. Even so, she argues, this doesn’t mean we should give up on treating cancer—in fact, evolutionary approaches offer new and promising options for the disease’s prevention and treatments that aim at long-term management rather than simple eradication. Looking across species—from sponges and cacti to dogs and elephants—we are discovering new mechanisms of tumor suppression and the many ways that multicellular life-forms have evolved to keep cancer under control. By accepting that cancer is a part of our biological past, present, and future—and that we cannot win a war against evolution—treatments can become smarter, more strategic, and more humane. Unifying the latest research from biology, ecology, medicine, and social science, The Cheating Cell challenges us to rethink cancer’s fundamental nature and our relationship to it.
The Emperor of All Maladies
| Author | : Siddhartha Mukherjee |
| Publisher | : Simon and Schuster |
| Total Pages | : 624 |
| Release | : 2011-08-09 |
| Genre | : Health & Fitness |
| ISBN | : 1439170916 |
Winner of the Pulitzer Prize and a documentary from Ken Burns on PBS, this New York Times bestseller is “an extraordinary achievement” (The New Yorker)—a magnificent, profoundly humane “biography” of cancer—from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence. Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.
Ecology and Evolution of Cancer
| Author | : Beata Ujvari |
| Publisher | : Academic Press |
| Total Pages | : 292 |
| Release | : 2017-02-08 |
| Genre | : Medical |
| ISBN | : 0128043806 |
Ecology and Evolution of Cancer is a timely work outlining ideas that not only represent a substantial and original contribution to the fields of evolution, ecology, and cancer, but also goes beyond by connecting the interfaces of these disciplines. This work engages the expertise of a multidisciplinary research team to collate and review the latest knowledge and developments in this exciting research field. The evolutionary perspective of cancer has gained significant international recognition and interest, which is fully understandable given that somatic cellular selection and evolution are elegant explanations for carcinogenesis. Cancer is now generally accepted to be an evolutionary and ecological process with complex interactions between tumor cells and their environment sharing many similarities with organismal evolution. As a critical contribution to this field of research the book is important and relevant for the applications of evolutionary biology to understand the origin of cancers, to control neoplastic progression, and to prevent therapeutic failures. - Covers all aspects of the evolution of cancer, appealing to researchers seeking to understand its origins and effects of treatments on its progression, as well as to lecturers in evolutionary medicine - Functions as both an introduction to cancer and evolution and a review of the current research on this burgeoning, exciting field, presented by an international group of leading editors and contributors - Improves understanding of the origin and the evolution of cancer, aiding efforts to determine how this disease interferes with biotic interactions that govern ecosystems - Highlights research that intends to apply evolutionary principles to help predict emergence and metastatic progression with the aim of improving therapies
Why Birds Matter
| Author | : Çagan H. Sekercioglu |
| Publisher | : University of Chicago Press |
| Total Pages | : 398 |
| Release | : 2016-08-24 |
| Genre | : Science |
| ISBN | : 022638277X |
For over one hundred years, ornithologists and amateur birders have jointly campaigned for the conservation of bird species, documenting not only birds’ beauty and extraordinary diversity, but also their importance to ecosystems worldwide. But while these avian enthusiasts have noted that birds eat fruit, carrion, and pests; spread seed and fertilizer; and pollinate plants, among other services, they have rarely asked what birds are worth in economic terms. In Why Birds Matter, an international collection of ornithologists, botanists, ecologists, conservation biologists, and environmental economists seeks to quantify avian ecosystem services—the myriad benefits that birds provide to humans. The first book to approach ecosystem services from an ornithological perspective, Why Birds Matter asks what economic value we can ascribe to those services, if any, and how this value should inform conservation. Chapters explore the role of birds in such important ecological dynamics as scavenging, nutrient cycling, food chains, and plant-animal interactions—all seen through the lens of human well-being—to show that quantifying avian ecosystem services is crucial when formulating contemporary conservation strategies. Both elucidating challenges and providing examples of specific ecosystem valuations and guidance for calculation, the contributors propose that in order to advance avian conservation, we need to appeal not only to hearts and minds, but also to wallets.
Explaining Cancer
| Author | : Anya Plutynski |
| Publisher | : Oxford University Press |
| Total Pages | : 272 |
| Release | : 2018-07-18 |
| Genre | : Science |
| ISBN | : 0190904585 |
In Explaining Cancer, Anya Plutynski addresses a variety of philosophical questions that arise in the context of cancer science and medicine. She begins with the following concerns: · How do scientists classify cancer? Do these classifications reflect nature's "joints"? · How do cancer scientists identify and classify early stage cancers? · What does it mean to say that cancer is a "genetic" disease? What role do genes play in "mechanisms for" cancer? · What are the most important environmental causes of cancer, and how do epidemiologists investigate these causes? · How exactly has our evolutionary history made us vulnerable to cancer? Explaining Cancer uses these questions as an entrée into a family of philosophical debates. It uses case studies of scientific practice to reframe philosophical debates about natural classification in science and medicine, the problem of drawing the line between disease and health, mechanistic reasoning in science, pragmatics and evidence, the roles of models and modeling in science, and the nature of scientific explanation.
The Message of Ecology
| Author | : Charles J. Krebs |
| Publisher | : Indo American Books |
| Total Pages | : 210 |
| Release | : 2007 |
| Genre | : Science |
| ISBN | : 9788189617431 |
Ecology Is A Fascinating Subject. This Is A Book To Introduce You To It And The Problems Ecologists Try To Analyze. Above All It Is An Attempt To Present The Subject In A Direct, Simple Form Without Including The Detail That Is Necessary In A More Conventional Textbook And Without Burdening The Subject With Abstruse Definitions Or Voluminous Statistics. So Do Not View This Book As A Text But As Supplemental Reading Designed For An Introductory Biology Course Or For A First Course In Ecology.
Living Downstream
| Author | : Sandra Steingraber |
| Publisher | : Virago Press |
| Total Pages | : 357 |
| Release | : 1999 |
| Genre | : Cancer |
| ISBN | : 9781860495359 |
Published more than three decades after Rachel Carson's Silent Spring warned of the impact of chemicals on the environment, this book offers a critique of current thinking on cancer and its causes. It argues that the evidence has been wilfully ignored, and that the environment is still being poisoned. Throughout her study, the author weaves two stories - of Rachel Carson and her battle to be heard and of her own cancer of the bladder, which she traces back to agricultural and industrial contamination.
Dynamics Of Cancer: Mathematical Foundations Of Oncology
| Author | : Dominik Wodarz |
| Publisher | : World Scientific |
| Total Pages | : 533 |
| Release | : 2014-04-24 |
| Genre | : Mathematics |
| ISBN | : 9814566381 |
The book aims to provide an introduction to mathematical models that describe the dynamics of tumor growth and the evolution of tumor cells. It can be used as a textbook for advanced undergraduate or graduate courses, and also serves as a reference book for researchers. The book has a strong evolutionary component and reflects the viewpoint that cancer can be understood rationally through a combination of mathematical and biological tools. It can be used both by mathematicians and biologists. Mathematically, the book starts with relatively simple ordinary differential equation models, and subsequently explores more complex stochastic and spatial models. Biologically, the book starts with explorations of the basic dynamics of tumor growth, including competitive interactions among cells, and subsequently moves on to the evolutionary dynamics of cancer cells, including scenarios of cancer initiation, progression, and treatment. The book finishes with a discussion of advanced topics, which describe how some of the mathematical concepts can be used to gain insights into a variety of questions, such as epigenetics, telomeres, gene therapy, and social interactions of cancer cells.
Genome Chaos
| Author | : Henry H. Heng |
| Publisher | : Academic Press |
| Total Pages | : 564 |
| Release | : 2019-05-25 |
| Genre | : Medical |
| ISBN | : 0128136367 |
Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine transports readers from Mendelian Genetics to 4D-genomics, building a case for genes and genomes as distinct biological entities, and positing that the genome, rather than individual genes, defines system inheritance and represents a clear unit of selection for macro-evolution. In authoring this thought-provoking text, Dr. Heng invigorates fresh discussions in genome theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine. - Bridges basic research and clinical application and provides a foundation for re-examining the results of large-scale omics studies and advancing molecular medicine - Gathers the most pressing questions in genomic and cytogenomic research - Offers alternative explanations to timely puzzles in the field - Contains eight evidence-based chapters that discuss 4d-genomics, genes and genomes as distinct biological entities, genome chaos and macro-cellular evolution, evolutionary cytogenetics and cancer, chromosomal coding and fuzzy inheritance, and more
