Experimental Therapeutics

Experimental Therapeutics
Author: Martin Wilkins
Publisher: CRC Press
Total Pages: 248
Release: 2003-03-27
Genre: Medical
ISBN: 9781841842905

As a general rule, for every 10,000 molecules screened in a given program in the laboratory, only one will survive to launch. To minimize costs, companies need to catch potential failures, due either to lack of clinical effect or toxicity, in the early discovery phase, long before they reach patients. Experimental Therapeutics introduces the dynamic and competitive discipline of experimental medicine. Informative, concise, and easy-to-read, the book emphasizes what scientists involved in drug discovery need to know about the rapid advances made in molecular biology, genetics, and technology. Each chapter starts with a summary box, has several high yield boxes, tables, and figures and ends with a reference section that has key URLs and carefully selected references to scientific papers. The book is a useful primer for anyone working to advance the pharmacological management of disease.

Oxford Guide to Behavioural Experiments in Cognitive Therapy

Oxford Guide to Behavioural Experiments in Cognitive Therapy
Author: Khadj Rouf
Publisher: OUP Oxford
Total Pages: 496
Release: 2004-05-06
Genre: Psychology
ISBN: 019100491X

Behavioural experiments are one of the central and most powerful methods of intervention in cognitive therapy. Yet until now, there has been no volume specifically dedicated to guiding physicians who wish to design and implement behavioural experiments across a wide range of clinical problems. The Oxford Guide to Behavioural Experiments in Cognitive Therapy fills this gap. It is written by clinicians for clinicians. It is a practical, easy to read handbook, which is relevant for practising clinicians at every level, from trainees to cognitive therapy supervisors. Following a foreword by David Clark, the first two chapters provide a theoretical and practical background for the understanding and development of behavioural experiments. Thereafter, the remaining chapters of the book focus on particular problem areas. These include problems which have been the traditional focus of cognitive therapy (e.g. depression, anxiety disorders), as well as those which have only more recently become a subject of study (bipolar disorder, psychotic symptoms), and some which are still in their relative infancy (physical health problems, brain injury). The book also includes several chapters on transdiagnostic problems, such as avoidance of affect, low self-esteem, interpersonal issues, and self-injurious behaviour. A final chapter by Christine Padesky provides some signposts for future development. Containing examples of over 200 behavioural experiments, this book will be of enormous practical value for all those involved in cognitive behavioural therapy, as well as stimulating exploration and creativity in both its readers and their patients.

Serotonin-Dopamine Interaction: Experimental Evidence and Therapeutic Relevance

Serotonin-Dopamine Interaction: Experimental Evidence and Therapeutic Relevance
Author: Giuseppe Di Giovanni
Publisher: Elsevier
Total Pages: 682
Release: 2008-09-26
Genre: Science
ISBN: 0080932681

This book provides a unique and timely multidisciplinary synthesis of our current knowledge of the anatomy, pharmacology, physiology and behavioral data of the serotonin (5-HT)-dopamine (DA) interactions. Central serotonergic and dopaminergic systems play a critical role in the regulation of normal and abnormal behaviors. Moreover, recent evidence suggests that the dysfunction of the DA and 5-HT neurotransmitter systems contribute to various mental disorders including depression, schizophrenia, drug addiction and Parkinson's disease. This extremely important topic is of wide interest within the scientific community, with relevance not only to specialists but also to general practitioners and students. The book provides a valuable contribution to the debate on new pharmacological approaches for several psychopathological states, with contributions from expert neuroscientists and pharmacologists who comprehensively survey the most significant currently active areas of dopamine/serotonin interactions. - Provides an understanding of the interaction between Serotonin and Dopamine - Appeals equally to specialists, general practitioners, students and researchers - Contributes to the debate on new pharmacological approaches to several psychopathological states - Gives a comprehensive anatomical description plus the physiology and pharmacology of dopaminergic and serotonergic systems - Singles out neuropsychiatric and suggests new therapeutic approaches

Mitochondrial Biology and Experimental Therapeutics

Mitochondrial Biology and Experimental Therapeutics
Author: Paulo J. Oliveira
Publisher: Springer
Total Pages: 696
Release: 2018-03-21
Genre: Medical
ISBN: 3319733443

This book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mitochondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mitochondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mitochondrial physiology, but it also links the molecular interactions within these pathways to a variety of diseases. It is one of the first books to combine state-of-the-art reviews regarding basic mitochondrial biology, the role of mitochondrial alterations in different diseases, and the importance of that organelle as a target for pharmacological and non-pharmacological interventions to improve human health. The different chapters highlight the chemical-biological linkages of the mitochondria in context with drug development and clinical applications.

Pharmacology and Therapeutics

Pharmacology and Therapeutics
Author: Scott A. Waldman
Publisher: Saunders
Total Pages: 0
Release: 2009
Genre: Chemotherapy
ISBN: 9781416060987

Everything you need to know about all of today's drugs in a coherent, easy-to-use format - from the underlying science through innovation, translation, regulation, and clinical implementation. This multimedia resource fills a critical need for a more clinically focused, user-friendly pharmacology reference. Evidence-based therapeutic guidelines facilitate decision making; and coverage of pharmacogenetics and pharmacogenomics, regenerative pharmacology, stem cell therapies, and the emerging field of individualized medicine keeps you at the forefront of the latest developments.

Drugs on Trial

Drugs on Trial
Author: Andreas-Holger Maehle
Publisher: Rodopi
Total Pages: 388
Release: 1999
Genre: Chemotherapy
ISBN: 9789042007833

This book describes the main issues of eighteenth-century pharmacology and therapeutics and provides detailed case studies of three key areas: lithontriptics (remedies against urinary stones), opium, and Peruvian bark (quinine).

Gastrointestinal Mucosal Repair and Experimental Therapeutics

Gastrointestinal Mucosal Repair and Experimental Therapeutics
Author: Chi-Hin Cho
Publisher: Karger Medical and Scientific Publishers
Total Pages: 260
Release: 2002-01-01
Genre: Medical
ISBN: 3805573820

Over the last decade, considerable progress has been made in understanding cellular and molecular mechanisms involved in gastrointestinal mucosal injury and repair. These findings provide the basis to identify the etiology and pathogenesis of various gut mucosal injury-related diseases and to develop new therapeutic approaches. The publication at hand is divided into three sections: Epithelial restitution, mucosal repair and ulcer healing, and experimental therapeutics. The first part highlights the early rapid mucosal restitution, focussing on the roles of extracellular matrix, cytoskeleton, cytokines, Ca2+ signaling, polyamines, and the protein kinase C/DAG pathways. The next section deals with aspects of chronic mucosal healing, concentrating on the roles of primary response gene expression, angiogenesis and angiogenic growth factors, platelets, and the mechanisms of cell renewal after injury in special circumstances. The last part explores new therapeutic approaches, stressing potential clinical applications of nitric oxide-releasing agents, polysaccharides, nitric oxide synthase modulators, growth factors, prostaglandins, and cyclooxygenase inhibitors. Covering the current state-of-the-art findings relevant to gut mucosal injury and repair as well as providing the underlying conceptual basis and knowledge regarding experimental therapeutics for gastrointestinal mucosal injury-related diseases, this publication will be a timely guide for investigators working in the field.

The Progress of Experiment

The Progress of Experiment
Author: Harry M. Marks
Publisher: Cambridge University Press
Total Pages: 276
Release: 1997
Genre: Medical
ISBN: 9780521785617

Explores the origins of contemporary drug regulation and the modern clinical trial.