Experimental Malignant Hyperthermia
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| Author | : Charles H. Williams |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 178 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 1461237386 |
Malignant hyperthermia is a genetic disease that causes an extremely high body temperature. The syndrome is triggered by depolarizing muscle relaxants and halogenated gaseous anesthetics, such as halothane. The purpose of the book is to present the latest experimental work and important conclusions to anesthesiologists, surgeons, certified registered nurse anesthesists, operating nurses, cardiovascular and temperature oriented physiologists, basic research scientists interested in heat production in muscle, animal scientists, primarily swine physiologists, and finally, muscle biology scientists. The results are based on sixteen years of experimental investigations with a malignant hyperthermia susceptible pig colony. Consequently, the data and conclusions are more concrete than the clinical data from human patients. The first five chapters present fresh material relating to the detailed biochemical mechanism of heat production during malignant hyperthermia. Subsequent chapters present recent data on malignant hyperthermia in horses and dogs; these additional animal models provide useful material for future studies of malignant hyperthermia pathophysiology. Later sections summarize the laboratory methods currently used for diagnosing malignant hyperthermia in human patients and present valuable data on malignant hyperthermia in the greater Kansas city area over a twenty year period.
| Author | : Charles H Williams |
| Publisher | : |
| Total Pages | : 184 |
| Release | : 1987-12-01 |
| Genre | : |
| ISBN | : 9781461237396 |
| Author | : Michio Morio |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 276 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 4431683461 |
In susceptible individuals, malignant hyperthermia (MH) can be triggered by various anesthetics during surgery. First described in 1960, research since then has concentrated on reducing the very high mortality rate associated with MH. Although significant progress in treatment has been made with the introduction of dantrolene sodium in 1979, many questions remain unanswered. Following on the results of more than 30 years of investigative efforts, the Third International Symposium on MH was held in Hiroshima, Japan, in 1994, immediately before the Seventh International Workshop on MH. Specialists in the field discussed the most up-to-date findings from the point of view of clinical classification, history, and incidence based on the evidence of epidemiology, diagnostic muscle testing, genetics, and biochemistry. These proceedings of the symposium present important keys to understanding the mechanism of MH and related syndromes at the genetic level and include procedures for the monitoring and care of patients. This volume will be invaluable not only for surgeons and anesthesiologists but also for physiologists and researchers.
| Author | : S. Tsuyoshi Ohnishi |
| Publisher | : CRC Press |
| Total Pages | : 348 |
| Release | : 2022-04-18 |
| Genre | : Medical |
| ISBN | : 0429611285 |
This book is dedicated to those who died of malignant hyperthermia and to their families. It contains cases studies that would be helpful for anesthesiologists, surgeons, physiologists, molecular biologists, biophysicists, biochemists, pathologists, students, and post doctoral fellows.
| Author | : David E. Longnecker |
| Publisher | : McGraw Hill Professional |
| Total Pages | : 1772 |
| Release | : 2012-05-23 |
| Genre | : Medical |
| ISBN | : 0071785132 |
Accompanying DVD-ROM contains ... "an image gallery and video clips of key procedures."--P. [4] of cover.
| Author | : Andras Szasz |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 575 |
| Release | : 2010-11-23 |
| Genre | : Medical |
| ISBN | : 9048194989 |
Oncothermia is the next generation medical innovation that delivers selective, controlled and deep energy for cancer treatment. The basic principles for oncothermia stem from oncological hyperthermia, the oldest approach to treating cancer. Nevertheless, hyperthermia has been wrought with significant controversy, mostly stemming from shortcomings of controlled energy delivery. Oncothermia has been able to overcome these insufficiencies and prove to be a controlled, safe and efficacious treatment option. This book is the first attempt to elucidate the theory and practice of oncothermia, based on rigorous mathematical and biophysical analysis, not centered on the temperature increase. It is supported by numerous in-vitro and in-vivo findings and twenty years of clinical experience. This book will help scientists, researchers and medical practitioners in understanding the scientific and conceptual underpinnings of oncothermia and will add another valuable tool in the fight against cancer. Professor Andras Szasz is the inventor of oncothermia and the Head of St Istvan University's Biotechnics Department in Hungary. He has published over 300 papers and lectured at various universities around the world. Dr. Oliver Szasz is the managing director of Oncotherm, the global manufacturer and distributor of medical devices for cancer treatment used in Europe & Asia since the late 1980s. Dr. Nora Szasz is currently a management consultant in healthcare for McKinsey & Co.
| Author | : Webb |
| Publisher | : Oxford University Press |
| Total Pages | : 1961 |
| Release | : 2020-01-10 |
| Genre | : Medical |
| ISBN | : 0198855435 |
Now in paperback, the second edition of the Oxford Textbook of Critical Care is a comprehensive multi-disciplinary text covering all aspects of adult intensive care management. Uniquely this text takes a problem-orientated approach providing a key resource for daily clinical issues in the intensive care unit. The text is organized into short topics allowing readers to rapidly access authoritative information on specific clinical problems. Each topic refers to basic physiological principles and provides up-to-date treatment advice supported by references to the most vital literature. Where international differences exist in clinical practice, authors cover alternative views. Key messages summarise each topic in order to aid quick review and decision making. Edited and written by an international group of recognized experts from many disciplines, the second edition of the Oxford Textbook of Critical Careprovides an up-to-date reference that is relevant for intensive care units and emergency departments globally. This volume is the definitive text for all health care providers, including physicians, nurses, respiratory therapists, and other allied health professionals who take care of critically ill patients.
| Author | : Brian Pollard |
| Publisher | : CRC Press |
| Total Pages | : 1766 |
| Release | : 2017-09-29 |
| Genre | : Medical |
| ISBN | : 1351674447 |
Written and edited by experts in the field, the Handbook of Clinical Anaesthesia provides all the essential practical knowledge required by anaesthetists on co-existing medical conditions, operative procedures, and techniques. The fourth edition retains the concise and comprehensive nature of the third, giving readers all they need to know about each part of the FRCA syllabus in short, digestible, practical entries. The first part covers Patient Conditions; the second Surgical Procedures; and the third Anaesthetic Factors. Each part is subdivided into chapter on each organ system, and each chapter is divided into bite-sized entries. These are in alphabetical order, and cover all common and rare conditions that anaesthetists will encounter within their practice. Avoiding prolonged discussion and multiple references, this is the ideal book to ‘dip into’ either for specific advice or general education, providing quick and reliable information. This is the most thorough handbook to cover the entire FRCA syllabus in a consistent and instructive manner. It continues to be accessible and relevant to all anaesthetists from middle grade trainee up to consultant/specialist.
| Author | : Fred F. Ferri |
| Publisher | : Elsevier Health Sciences |
| Total Pages | : 7615 |
| Release | : 2019-06-01 |
| Genre | : Medical |
| ISBN | : 0323679773 |
Significantly updated with the latest developments in diagnosis and treatment recommendations, Ferri's Clinical Advisor 2020 features the popular "5 books in 1" format to organize vast amounts of information in a clinically relevant, user-friendly manner. This efficient, intuitive format provides quick access to answers on 1,000 common medical conditions, including diseases and disorders, differential diagnoses, and laboratory tests – all reviewed by experts in key clinical fields. Updated algorithms, along with hundreds of new figures, tables, and boxes, ensure that you stay current with today's medical practice. - Contains significant updates throughout, covering all aspects of current diagnosis and treatment. - Features 27 all-new topics including chronic traumatic encephalopathy, medical marijuana, acute respiratory failure, gallbladder carcinoma, shift work disorder, radial tunnel syndrome, fertility preservation in women, fallopian tube cancer, primary chest wall cancer, large-bowel obstruction, inguinal hernia, and bundle branch block, among others. - Includes a new appendix covering Physician Quality Reporting System (PQRS) Measures. - Provides current ICD-10 insurance billing codes to help expedite insurance reimbursements. - Patient Teaching Guides for many of the diseases and disorders are included, most available in both English and Spanish versions, which can be downloaded and printed for patients.
| Author | : Devashish Shrivastava |
| Publisher | : John Wiley & Sons |
| Total Pages | : 897 |
| Release | : 2018-07-02 |
| Genre | : Science |
| ISBN | : 1119127300 |
An authoritative guide to theory and applications of heat transfer in humans Theory and Applications of Heat Transfer in Humans 2V Set offers a reference to the field of heating and cooling of tissue, and associated damage. The author—a noted expert in the field—presents, in this book, the fundamental physics and physiology related to the field, along with some of the recent applications, all in one place, in such a way as to enable and enrich both beginner and advanced readers. The book provides a basic framework that can be used to obtain ‘decent’ estimates of tissue temperatures for various applications involving tissue heating and/or cooling, and also presents ways to further develop more complex methods, if needed, to obtain more accurate results. The book is arranged in three sections: The first section, named ‘Physics’, presents fundamental mathematical frameworks that can be used as is or combined together forming more complex tools to determine tissue temperatures; the second section, named ‘Physiology’, presents ideas and data that provide the basis for the physiological assumptions needed to develop successful mathematical tools; and finally, the third section, named ‘Applications’, presents examples of how the marriage of the first two sections are used to solve problems of today and tomorrow. This important text is the vital resource that: Offers a reference book in the field of heating and cooling of tissue, and associated damage. Provides a comprehensive theoretical and experimental basis with biomedical applications Shows how to develop and implement both, simple and complex mathematical models to predict tissue temperatures Includes simple examples and results so readers can use those results directly or adapt them for their applications Designed for students, engineers, and other professionals, a comprehensive text to the field of heating and cooling of tissue that includes proven theories with applications. The author reveals how to develop simple and complex mathematical models, to predict tissue heating and/or cooling, and associated damage.
