This book presents Integrated Thematic Instruction (ITI), a model for implementing a "brain-compatible" learning environment for students and teachers using a year-long theme to organize curriculum content and skills. The book's introduction identifies six "mismemes" (or mistaken ideas) that have hindered educational reform, and proposes seven "new memes" (or foundational premises) for education reform that are consistent with brain research and children's developmental characteristics. Also identified are eight brain-compatible implementation elements to create an environment that will enhance children's performance and provide the basis for successful learning experience. Chapter 1 then describes the three principles of the ITI model: that brain research must become the basis for decisions to improve education, that teaching is an art and science that must implement brain research in the classroom, and that curriculum development must occur at the classroom level based on the classroom teacher's understanding of the learners and community. Chapters 2 through 9 explain the eight brain-compatible implementation elements and how they can be applied to learning. The eight elements are: (1) absence of threat; (2) meaningful content; (3) choices; (4) adequate time; (5) enriched environment; (6) collaboration; (7) immediate feedback; and (8) mastery (application). Chapter 10 describes a brain-compatible curriculum, one that emphasizes pattern-seeking and program-building. Chapters 11 through 13 describe three steps in curriculum making: creating a year-long theme, determining the key concepts and skills to be mastered within year-long themes, and creating and using inquiries. Chapter 14 shows how the ITI model is not incompatible with teaching reading, writing, and mathematics skills. Finally, chapter 15 argues the need for personal transition if change is to be made. Five appendices present sample materials for building an ITI program. A glossary is included. Contains 35 references. (TM)