Etude De Linteraction Medicament Recepteur Par Spectrometrie De Masse
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Author | : Paul Hannewald |
Publisher | : |
Total Pages | : 0 |
Release | : 2008 |
Genre | : |
ISBN | : |
La découverte de nouveaux médicaments par le criblage biomoléculaire est au centre de la recherche pharmaceutique actuelle. La spectrométrie de masse, en tant que technique d'analyse fiable, reproductible, sensible, spécifique, compatible avec de nombreux types d'échantillons et permettant un débit d'analyse conséquent, trouve ainsi sa place dans les stratégies de recherche et développement de nouveaux médicaments. Le but de ce travail était de mettre en place et de valider une stratégie originale, impliquant la désorption/ionisation laser assistée par matrice couplée à la spectrométrie de masse (MALDI-MS) comme technique de détection, en vue du criblage de la liaison de composés à des cibles moléculaires applicable directement à des extraits de plantes. Le protocole que nous avons développé s'articule en trois étapes successives qui sont l'incubation des molécules à tester avec la cible moléculaire choisie (la tubuline ou la DHFR), l'élimination des composés non liés et enfin l'analyse par MALDI-TOFMS des composés liés. Notre démarche a fait l'objet d'une démarche de validation et les résultats pouvant être obtenus ont été discutés. Le débit pouvant être évalué à 60 échantillons en 1h50 à 3h30 soit de 18 à 32 échantillons à l'heure. Enfin, une démarche innovante nous a permis de prouver que notre approche pouvait être utile également en criblage secondaire. L'application de notre approche à des extraits bruts de plantes (Colchique d'Automne, Pervenche de Madagascar et Thé vert) à permis de mettre en évidence 20 molécules actives se liant à l'une ou l'autre des cibles moléculaires utilisées et d'évaluer l'affinité relative de l'une d'entre elles.
Author | : Ahmed Belasri |
Publisher | : Springer Nature |
Total Pages | : 659 |
Release | : 2020-06-10 |
Genre | : Technology & Engineering |
ISBN | : 9811554447 |
This book highlights peer reviewed articles from the 1st International Conference on Renewable Energy and Energy Conversion, ICREEC 2019, held at Oran in Algeria. It presents recent advances, brings together researchers and professionals in the area and presents a platform to exchange ideas and establish opportunities for a sustainable future. Topics covered in this proceedings, but not limited to, are photovoltaic systems, bioenergy, laser and plasma technology, fluid and flow for energy, software for energy and impact of energy on the environment.
Author | : Linda Diann Urden |
Publisher | : Saunders |
Total Pages | : 1242 |
Release | : 2010 |
Genre | : Medical |
ISBN | : |
Focusing on critical care nursing, this full-color text provides an examination of the important aspects of critical care nursing. It is organized in ten units around alterations in body systems.
Author | : John F. Watts |
Publisher | : John Wiley & Sons |
Total Pages | : 307 |
Release | : 2019-08-27 |
Genre | : Technology & Engineering |
ISBN | : 1119417643 |
Provides a concise yet comprehensive introduction to XPS and AES techniques in surface analysis This accessible second edition of the bestselling book, An Introduction to Surface Analysis by XPS and AES, 2nd Edition explores the basic principles and applications of X-ray Photoelectron Spectroscopy (XPS) and Auger Electron Spectroscopy (AES) techniques. It starts with an examination of the basic concepts of electron spectroscopy and electron spectrometer design, followed by a qualitative and quantitative interpretation of the electron spectrum. Chapters examine recent innovations in instrument design and key applications in metallurgy, biomaterials, and electronics. Practical and concise, it includes compositional depth profiling; multi-technique analysis; and everything about samples—including their handling, preparation, stability, and more. Topics discussed in more depth include peak fitting, energy loss background analysis, multi-technique analysis, and multi-technique profiling. The book finishes with chapters on applications of electron spectroscopy in materials science and the comparison of XPS and AES with other analytical techniques. Extensively revised and updated with new material on NAPXPS, twin anode monochromators, gas cluster ion sources, valence band spectra, hydrogen detection, and quantification Explores key spectroscopic techniques in surface analysis Provides descriptions of latest instruments and techniques Includes a detailed glossary of key surface analysis terms Features an extensive bibliography of key references and additional reading Uses a non-theoretical style to appeal to industrial surface analysis sectors An Introduction to Surface Analysis by XPS and AES, 2nd Edition is an excellent introductory text for undergraduates, first-year postgraduates, and industrial users of XPS and AES.
Author | : Alan D. Lopez |
Publisher | : World Bank Publications |
Total Pages | : 511 |
Release | : 2006-04-02 |
Genre | : Medical |
ISBN | : 0821362631 |
Strategic health planning, the cornerstone of initiatives designed to achieve health improvement goals around the world, requires an understanding of the comparative burden of diseases and injuries, their corresponding risk factors and the likely effects of invervention options. The Global Burden of Disease framework, originally published in 1990, has been widely adopted as the preferred method for health accounting and has become the standard to guide the setting of health research priorities. This publication sets out an updated assessment of the situation, with an analysis of trends observed since 1990 and a chapter on the sensitivity of GBD estimates to various sources of uncertainty in methods and data.
Author | : International Livestock Research Institute |
Publisher | : ILRI (aka ILCA and ILRAD) |
Total Pages | : 268 |
Release | : 1995-01-01 |
Genre | : Animal industry |
ISBN | : 9789291460038 |
Policy concepts; Identification of policy issues; Production systems, supply and demand; Market, price and trade policies; Marketing and distribution systems; Budget and manpower planning; Land tenure police for the livestock sector; Policy analysis report writing and communication; Livestock production and marketing in alphabeta - a case study.
Author | : Ulrich Flogel |
Publisher | : CRC Press |
Total Pages | : 426 |
Release | : 2016-10-26 |
Genre | : Medical |
ISBN | : 1315340933 |
Over the past decade, fluorine (19F) magnetic resonance imaging (MRI) has garnered significant scientific interest in the biomedical research community owing to the unique properties of fluorinated materials and the 19F nucleus. Fluorine has an intrinsically sensitive nucleus for MRI. There is negligible endogenous 19F in the body and thus there is no background signal. Fluorine-containing compounds are ideal tracer labels for a wide variety of MRI applications. Moreover, the chemical shift and nuclear relaxation rate can be made responsive to physiology via creative molecular design. This book is an interdisciplinary compendium that details cutting-edge science and medical research in the emerging field of 19F MRI. Edited by Ulrich Flögel and Eric Ahrens, two prominent MRI researchers, this book will appeal to investigators involved in MRI, biomedicine, immunology, pharmacology, probe chemistry, and imaging physics.
Author | : Centre national de la recherche scientifique (France) Centre de documentation scientifique et technique |
Publisher | : |
Total Pages | : 694 |
Release | : 1977 |
Genre | : Pharmacology |
ISBN | : |
Author | : Alain Reinberg |
Publisher | : CRC Press |
Total Pages | : 268 |
Release | : 1990-07 |
Genre | : Design |
ISBN | : |
Periodical and predictable changes in biological susceptibility and response to a large variety of chemical agents, including drugs and food, have been documented since the early 1970s. This book provides a survey of clinically-documented research in chronopharmacology.
Author | : Mark S. Meskin |
Publisher | : CRC Press |
Total Pages | : 221 |
Release | : 2002-03-19 |
Genre | : Medical |
ISBN | : 1420031694 |
Are soy isoflavones neuroprotective? Just how different is one species of Echinacea from another? Which phytochemicals will be effective as therapeutic agents in vivo? Supported by solid scientific research, Phytochemicals in Nutrition and Health helps provide answers to these and other probing questions concerning the mechanisms of action associat