Epidermal Lipoxygenase Products
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Lipoxygenases and Their Products
| Author | : Stanley Crooke |
| Publisher | : Academic Press |
| Total Pages | : 313 |
| Release | : 2012-12-02 |
| Genre | : Science |
| ISBN | : 0323156533 |
Lipoxygenases and Their Products provides a cogent summary of the advances in understanding lipoxygenases and their products, emphasizing their pharmacology and pathophysiology; regulation and structure; physiological role; and receptors and receptor antagonists. This text also reviews the literature where specific receptor antagonists (as opposed to enzymatic inhibitors) have been used to characterize the pharmacologic action and the pathophysiologic roles of some of lipoxygenase products of arachidonic acid metabolism. This book is organized into 11 chapters and begins with an overview of the biochemical, pharmacological, and pathophysiological aspects of 5-lipoxygenase products of arachidonic acid metabolism in the respiratory, cardiovascular, renal, gastrointestinal, and central nervous systems. The discussion then shifts to human 5-lipoxygenase, emphasizing this enzyme purification, stimulatory factors, and membrane translocation. The reader is methodically introduced to 5-lipoxygenase activity in rats and pigs; the potential and therapeutic value of 5-lipoxygenase inhibitors; the distribution of 15-lipoxygenase in cells or tissues; and products formed through the 15-lipoxygenase pathway. This book also considers lipoxins and third-generation peptidoleukotriene receptor antagonists, and then concludes with a summary of the physiological and pathophysiological effects of leukotrienes and lipoxins in a variety of organs. This book is of interest to scientists interested in arachidonic acid and its metabolites, to scientists engaged in drug discovery-and-development activities in academia and the pharmaceutical industry, and to clinicians interested in diseases associated with leukotrienes and related products.
Eicosanoids and the Skin
| Author | : Thomas Ruzicka |
| Publisher | : CRC Press |
| Total Pages | : 230 |
| Release | : 1990-03-30 |
| Genre | : Medical |
| ISBN | : 9780849360329 |
This publication summarizes the increasing knowledge in eicosanoid research. It provides a detailed overview of this rapidly expanding field. The text contains sections on general aspects of arachidonic acid metabolism, the role of eicosanoids in skin diseases, and their biological and biochemical effects in skin. Also included is a section on inhibitors of arachidonic acid metabolism with particular reference to use in dermatology. New concepts covered are: possible physiological role of lipoxygenase products in cutaneous wound healing, restoration and maintenance of cutaneous integrity, and the recently recognized protective function of prostaglandins in skin. It is an invaluable resource for individuals involved with dermatology, pharmacology, inflammation, immunology, biochemistry, physiology, internal medicine and therapeutics.
New Trends in Allergy III
| Author | : Johannes Ring |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 577 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 3642467172 |
The international symposium "New Trends in Allergy", held in Munich from July 13 to 15, 1990, brought together for the third time since 1980 some of the most experienced researchers working in the field of allergy. This volume comprises the papers presented at this meeting. All over the world, and not merely in the industrialized countries, allergy is becoming a cause of evermore serious diseases. In recent years, research in the field of allergy has provided numerous impor tant and fascinating results extending our knowledge considerably. Despite the new insights into basic mechanisms of allergic reactions, improved diagnostic methods, and new therapeutic approaches, how ever, many questions remain to be answered, including: Are allergies really increasing in frequency? If so, what are the reasons? Especially, does environmental pollution playa role? Which factors influence IgE synthesis? Can the IgE immune response be switched off? Does the nervous system interact with allergic reactions? If so, what are the mechanisms? Are new approaches in allergy prophylaxis and allergy therapy effi cient? What measures have proven useful and deserve to be employed in daily practice? In this volume, these questions and other current topics are dealt with. As each issue is covered by authors competent in the respective fields, the result is an extensive and critical review of the state of the art. Going through these papers, one comes to the conviction that allergy research is a multifacetted, explosively expanding, most stimulating field of work.
Amphioxus Immunity
| Author | : An-Long Xu |
| Publisher | : Elsevier |
| Total Pages | : 306 |
| Release | : 2015-12-31 |
| Genre | : Medical |
| ISBN | : 0128096470 |
Amphioxus Immunity: Tracing the Origin of Human Immunity covers a remarkable range of information about Amphioxus and its evolutionary context. This compilation of what is currently known about Amphioxus, with a sharp focus on its immune system, includes 13 topics, such as: - Amphioxus as a model for understanding the evolution of vertebrates - basic knowledge of immunology - immune organs and cells of amphioxus - a genomic and transcriptomic view of the Amphioxus immunity - pattern recognition system in Amphioxus - transcription factors in Amphioxus - the complement system of Amphioxus - the oxidative burst system in Amphioxus - immune effectors in Amphioxus - lipid signaling of immune response in Amphioxus - apoptosis in amphioxus; primitive adaptive immune system of Amphioxus - and future research directions This valuable reference book is loaded with information that will be useful for anyone who wishes to learn more about the origin of vertebrates and adaptive immunity. - Provides new evidence on the origin of the adaptive immune system, the evolution of innate immunity, and evolution-stage specific immune defense mechanisms - Not only presents the cells and molecules involved in the adaptive immune response in Amphioxus, but also characterizes the origination and evolution of the gene families and pathways involved in innate immunity - Includes much pioneering work, from the molecular, genomic, and cellular to the individual level
Systematic Approach to Evaluation of Mouse Mutations
| Author | : John P. Sundberg |
| Publisher | : CRC Press |
| Total Pages | : 216 |
| Release | : 2019-10-17 |
| Genre | : |
| ISBN | : 9780367399580 |
Experts from The Jackson Laboratory and around the world provide practical advice on everything from how to establish a colony to where to go for specific mutations. Systematic Approach to Evaluation of Mouse Mutations includes information on medical photography, grafting procedures, how to map the genes and evaluate the special biological characteristics of the mice.
Antioxidant and Redox Regulation of Genes
| Author | : Chandan K. Sen |
| Publisher | : Academic Press |
| Total Pages | : 591 |
| Release | : 1999-11-08 |
| Genre | : Science |
| ISBN | : 0080527299 |
This volume addresses oxidant-reduction or redox and antioxidant sensitive molecular mechanisms and how they are implicated in different disease processes. Possible strategies to pharmacologically and/or nutritionally manipulate such redox-sensitive molecular responses are emphasized. - Reactive species as intracellular messengers - Redox regulation of cellular responses - Clinical implications of redox signaling and antioxidant therapy
The Endothelium
| Author | : Michel Félétou |
| Publisher | : Morgan & Claypool Publishers |
| Total Pages | : 309 |
| Release | : 2011 |
| Genre | : Science |
| ISBN | : 1615041230 |
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
The Ichthyoses
| Author | : Heiko Traupe |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 270 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 3642736505 |
It is a great pleasure for me to see this work in print. As outlined by Dr. Traupe, at least 20 different types of ichthyosis have been identified to date. This book will effectively help to establish a correct diagnosis, as a basis for genetic counseling. Dr. Traupe proposes a new classification of the ichthyoses, based on reason able clinical criteria. He lets the reader share in his enormous knowledge and safely guides him through the difficult field of nomenclature. He describes the particular nature of these scaling disorders in a manner as simple as possible. During the last few years, research on ichthyosis has become a fascinating scientific challenge due to the introduction of novel investigative approaches. The main advantage of this book lies in the fact that the author successfully combines recent achievements made in lipid analysis, enzymology, electron microscopy, and molecular genetics. Heiko Traupe began his career in dermatology 11 years ago, as a resident in the Department of Dermatology in Munster. As we were both interested in the genetic aspects of skin diseases, this was the starting point of a most fruitful collaboration, which is still continuing. During our common work in Munster, Dr. Traupe was able, thanks to his unceasing clinical curiosity, to describe many novel aspects within the field of ichthyosis, and I took pride in coauthoring papers on new items such as cryptorchidism as a fea ture associated with X-linked recessive ichthyosis, autosomal dominant lamellar ichthyosis, and alopecia ichthyotica.
Lipoxygenases in Inflammation
| Author | : Dieter Steinhilber |
| Publisher | : Springer |
| Total Pages | : 252 |
| Release | : 2016-04-27 |
| Genre | : Medical |
| ISBN | : 3319277669 |
Oxidation of polyunsaturated fatty acids by lipoxygenases leads to a variety of fatty acid metabolites which play important roles in physiology but also in pathophysiology. Data accumulated during the last decade point to the fact that lipoxygenase metabolites are involved in host defence reactions, cardiovascular system and contribute to the development of inflammatory and allergic diseases, cardiovascular disease and cancer. This PIR volume summarizes the physiological and pathophysiological functions of lipoxygenases.
