Drug Targets In Kinetoplastid Parasites
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| Author | : Hemanta K. Majumder |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 174 |
| Release | : 2008-09-15 |
| Genre | : Medical |
| ISBN | : 0387775706 |
The dreaded protozoal diseases caused by a number of Kinetoplastid parasites threaten mankind, as therapeutic tools for the treatment of most parasitic diseases are extremely limited. Development of commercially available vaccines is still far from reality, though research and trial programs continue. This book covers current research into drug therapeutics for the conditions caused by the parasites, which if viewed globally, pose an increasing threat to human health and welfare.
| Author | : Luis Rivas |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 422 |
| Release | : 2017-10-26 |
| Genre | : Science |
| ISBN | : 1788012585 |
For human health, leishmaniasis is among the most important protozoan diseases, superseded only by malaria. Globally, 10 to 12 million people are infected with 1.5 million new cases every year. The development of cheaper new drugs is urgently needed for this neglected disease that is developing resistance to current treatments. Chemotherapy remains the only treatment option for the bulk of patients. However, this is largely unaffordable for most. In the past three years numerous advances in drug discovery have been made for treating this disease by exploiting diverging metabolic pathways between the Leishmania enzymes and their hosts, using nanotechnology to target the immune cell phagolysosomes where Leishmania resides. Drug Discovery for Leishmaniasis aims to provide a perspective of the current treatments and their challenges, blended with the emerging strategies and methodologies that will drive new target appraisals and drug developments, as well as addressing the molecular basis of resistance in Leishmania. Recent studies have shown that leishmaniasis affects some of the poorest people in the world, with 95% of fatal cases occurring in only 6 countries. With the WHO goal of eliminating this public health problem in the South-east Asia Region by 2020, this book will be important for anyone who is interested in neglected tropical diseases.
| Author | : Hemanta K. Majumder |
| Publisher | : Springer |
| Total Pages | : 0 |
| Release | : 2011-01-24 |
| Genre | : Medical |
| ISBN | : 9781441926562 |
The dreaded protozoal diseases caused by a number of Kinetoplastid parasites threaten mankind, as therapeutic tools for the treatment of most parasitic diseases are extremely limited. Development of commercially available vaccines is still far from reality, though research and trial programs continue. This book covers current research into drug therapeutics for the conditions caused by the parasites, which if viewed globally, pose an increasing threat to human health and welfare.
| Author | : Hemanta K. Majumder |
| Publisher | : |
| Total Pages | : 246 |
| Release | : 2018 |
| Genre | : Medical |
| ISBN | : 9781910190715 |
Written by a team of authors active in the field of Leishmania and Trypanosoma research, this volume reviews the current research in kinetoplastid parasites. This timely and up-to-date volume is essential reading for anyone working on kinetoplastid parasites. All parasitology laboratories should have a copy of this important reference volume.
| Author | : Jenny Telleria |
| Publisher | : Elsevier |
| Total Pages | : 871 |
| Release | : 2010-09-03 |
| Genre | : Medical |
| ISBN | : 0123848776 |
Chagas disease causes severe socioeconomic impact and a high medical cost in Latin America. WHO and the World Bank consider Chagas disease as the fourth most transmittable disease to have a major impact on public health in Latin America: 120 million persons are potentially exposed, 16 to 18 million of whom are presently infected, causing 45,000 to 50,000 deaths per year. It has been calculated that approximately 2.4 million potential working years are lost because of incapacity and mortality due to the disease, for an annual cost estimated at 20 billion Euros. American Trypanosomiasis provides a comprehensive overview of Chagas disease and discusses the latest discoveries concerning the three elements that compose the transmission chain of the disease: - The host: human and mammalian reservoirs - The insect vectors: domestic and sylvatic vectors - The causative parasite: Trypanosoma cruzi - Informs and updates on all the latest developments in the field - Contributions from leading authorities and industry experts
| Author | : Sharron H. Francis |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 531 |
| Release | : 2011-06-21 |
| Genre | : Medical |
| ISBN | : 364217969X |
Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.
| Author | : Alicia Ponte-Sucre |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 458 |
| Release | : 2012-09-04 |
| Genre | : Medical |
| ISBN | : 3709111250 |
One of the main problems concerning therapeutic tools for the treatment of parasitic diseases, including leishmaniasis, is that some field parasites are naturally resistant to the classical drugs; additionally, current therapies may select parasites prone to be resistant to the applied drugs. These features are (at least partially) responsible for the disappointing persistence of the disease and resultant deaths worldwide. This book provides a comprehensive view of the pathology of the disease itself, and of parasitic drug resistance, its molecular basis, consequences and possible treatments. Scientists both from academic fields and from the industry involved in biomedical research and drug design, will find in this book a valuable and fundamental guide that conveys the knowledge needed to understand and to improve the success in combating this disease worldwide.
| Author | : Christian Doerig |
| Publisher | : John Wiley & Sons |
| Total Pages | : 433 |
| Release | : 2013-10-11 |
| Genre | : Medical |
| ISBN | : 352767537X |
This is the first book to collect and summarize in one publication the efforts to use kinases or phosphatases for drug development against parasite infections. The editors and contributors comprise the Who is Who in the field, and they are comprehensive in covering every aspect of the topic, from basic research findings to translational approaches in drug development The result will be welcomed by everyone in academia and industry participating in the global effort to finally combat the major diseases caused by eukaryotic parasites. This is volume one of a two-volume treatise, the second being exclusively dedicated to efforts to combat malaria using the same approach.
| Author | : Michel Tibayrenc |
| Publisher | : Elsevier |
| Total Pages | : 1002 |
| Release | : 2024-07-19 |
| Genre | : Medical |
| ISBN | : 0443288194 |
Genetics and Evolution of Infectious Diseases, Third Edition discusses the evolving field of infectious diseases and their continued impact on the health of populations, especially in resource-limited areas of the world where they must confront the dual burden of death and disability due to infectious and chronic illnesses. Although substantial gains have been made in public health interventions for the treatment, prevention, and control of infectious diseases, in recent decades the world has witnessed the emergence of the human immunodeficiency virus (HIV) and the COVID-19 pandemic, increasing antimicrobial resistance, and the emergence of many new bacterial, fungal, parasitic, and viral pathogens. Fully updated and revised, this new edition presents the consequences of such diseases, the evolution of infectious diseases, the genetics of host-pathogen relationship, and the control and prevention strategies that are, or can be, developed. This book offers valuable information to biomedical researchers, clinicians, public health practitioners, decisions-makers, and students and postgraduates studying infectious diseases, microbiology, medicine, and public health that is relevant to the control and prevention of neglected and emerging worldwide diseases. - Takes an integrated approach to infectious diseases - Provides the latest developments in the field of infectious diseases - Focuses on the contribution of evolutionary and genomic studies for the study and control of transmissible diseases - Includes updated and revised contributions from leading authorities, along with six new chapters
| Author | : John M. Archibald |
| Publisher | : Springer |
| Total Pages | : 0 |
| Release | : 2017-08-16 |
| Genre | : Science |
| ISBN | : 9783319281476 |
Published in a modern, user-friendly format this fully revised and updated edition of The Handbook of Protoctista (1990) is the resource for those interested in the biology, diversity and evolution of eukaryotic microorganisms and their descendants, exclusive of animals, plants and fungi. With chapters written by leading researchers in the field, the content reflects the present state of knowledge of the cell and genome biology, evolutionary relationships and ecological/medical/economic importance each major group of protists, organized according to current protist systematics as informed by molecular phylogenetics and genomics.
