Dna Repair In Cancer Therapy
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| Author | : Mark R. Kelley |
| Publisher | : Academic Press |
| Total Pages | : 466 |
| Release | : 2016-06-07 |
| Genre | : Science |
| ISBN | : 0128035994 |
DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment. Experts on DNA repair proteins from all areas of cancer biology research take readers from bench research to new therapeutic approaches. This book provides a detailed discussion of combination therapies, in other words, how the inhibition of repair pathways can be coupled with chemotherapy, radiation, or DNA damaging drugs. Newer areas in this edition include the role of DNA repair in chemotherapy induced peripheral neuropathy, radiation DNA damage, Fanconi anemia cross-link repair, translesion DNA polymerases, BRCA1-BRCA2 pathway for HR and synthetic lethality, and mechanisms of resistance to clinical PARP inhibitors. - Provides a comprehensive overview of the basic and translational research in DNA repair as a cancer therapeutic target - Includes timely updates from the earlier edition, including Fanconi Anemia cross-link repair, translesion DNA polymerases, chemotherapy induced peripheral neuropathy, and many other new areas within DNA repair and cancer therapy - Saves academic, medical, and pharma researchers time by allowing them to quickly access the very latest details on DNA repair and cancer therapy - Assists researchers and research clinicians in understanding the importance of the breakthroughs that are contributing to advances in disease-specific research
| Author | : Clark Chen |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 676 |
| Release | : 2013-05-22 |
| Genre | : Medical |
| ISBN | : 9535111140 |
This book is intended for students and scientists working in the field of DNA repair. Select topics are presented here to illustrate novel concepts in DNA repair, the cross-talks between DNA repair and other fundamental cellular processes, and clinical translational efforts based on paradigms established in DNA repair. The book should serve as a supplementary text in courses and seminars as well as a general reference for biologists with an interest in DNA repair.
| Author | : |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2002 |
| Genre | : Cells |
| ISBN | : 9780815332183 |
| Author | : Ashis K. Basu |
| Publisher | : MDPI |
| Total Pages | : 275 |
| Release | : 2018-08-27 |
| Genre | : Science |
| ISBN | : 3038971294 |
This book is a printed edition of the Special Issue " Chemically-Induced DNA Damage, Mutagenesis, and Cancer" that was published in IJMS
| Author | : Miriam Christine Poirier |
| Publisher | : World Scientific |
| Total Pages | : 391 |
| Release | : 2018-09-28 |
| Genre | : Medical |
| ISBN | : 981323721X |
As chemical exposures and cancer rates increase worldwide, there is a need for students, researchers, public health professionals, and physicians to understand the mechanisms connecting exposure with human cancer risk. This new book is an essential reference, as well as introduction to the field of chemical carcinogenesis, with particular focus on DNA damage as a critical link between exposure and disease, and emphasis on biomarkers associated with cancer risk in humans. In addition to DNA damage, related topics covered include metabolism of selected chemical carcinogens, exposure-induced epigenetic changes, cancer-associated mutations and reduction of DNA damage and cancer risk by chemoprevention. The book is designed to be a comprehensive guide to basic principles, a teaching tool for academics, and a map for the development of protective mechanisms to reduce human cancer risk.
| Author | : Csaba Szabo |
| Publisher | : CRC Press |
| Total Pages | : 354 |
| Release | : 2000-06-22 |
| Genre | : Medical |
| ISBN | : 1420038893 |
Poly (ADP-ribose) polymerase (PARP), also termed poly (ADP-ribose) synthetase (PARS) is a nuclear enzyme with a wide range of functions, including regulation of DNA repair, cell differentiation, and gene expression. More than a decade after the identification of PARP-like enzymatic activities in mammalian cells, a novel role was proposed for this e
| Author | : Michael Lübbert |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 332 |
| Release | : 2013-12-12 |
| Genre | : Medical |
| ISBN | : 3642384048 |
The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders is now being translated into treatment approaches that target the epigenetic defects pharmacologically. This book first presents the latest evidence regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA methylation abnormalities in hematopoietic disorders and of epigenetic disturbances in lung cancer and other solid tumors is then discussed. A major part of the book, however, relates specifically to the translation of basic research and drug development to clinical applications, and in this context both present and future clinical strategies are considered. Individual chapters are devoted to the use of DNA hypomethylating agents and chromatin-modifying agents, and the treatment of hematologic malignancies and solid tumors by means of epigenetic agents is discussed in detail.
| Author | : Srinivasan Madhusudan |
| Publisher | : CRC Press |
| Total Pages | : 720 |
| Release | : 2013-01-22 |
| Genre | : Medical |
| ISBN | : 1466577436 |
DNA repair is a rapidly advancing field in biology and these systems represent a major defense mechanism against environmental and intracellular damaging agents such as sunlight, ionizing radiation, and reactive oxygen species. With contributions from eminent researchers, this book explores the basics and current trends in this critical field. Topics include carcinogenesis as a predictive and/or prognostic biomarker for cancer therapy, nucleotide excision repair, and tumor genetics and personalized medicine. The contributions provide essential information to scientists, pharmaceutical investigators, and clinicians interested in cancer therapy.
| Author | : Malcolm Alison |
| Publisher | : Nature Publishing Group |
| Total Pages | : 928 |
| Release | : 2002 |
| Genre | : Medical |
| ISBN | : |
Provides a comprehensive overview of all major areas of cancer research and oncology. Bridging the gap between the molecular biology of cancer and clinical diagnosis and treatment, this online reference work provides a resource for medical and life sciences students, as well as all scientists, clinicians and researchers working in the cancer field and related biomedical areas.
| Author | : Theodor Boveri |
| Publisher | : |
| Total Pages | : 119 |
| Release | : 1929 |
| Genre | : Cancer |
| ISBN | : |
The translation helped bring her husband's chromosome theory of cancer to the attention of a wider audience and rediscover his work.
