A new translation of Denis Diderot's 1751 On the Interpretation of Nature from the original French manuscript into American English. This edition contains an afterword by the translator on Diderot's philosophic legacy, a timeline of his works and life, and a glossary of philosophic terminology utilized in his works. "Thoughts on the Interpretation of Nature" is a philosophical work by Denis Diderot in which he delves into the nature of scientific inquiry and the methods of interpreting the natural world. Diderot critically examines the prevailing scientific practices of his time and challenges the notion that a single, fixed interpretation of nature is attainable. He argues for a more comprehensive approach to scientific observation, emphasizing the importance of considering the interconnectedness and complexity of natural phenomena and pushing back on some of the Enlightenment's untethered rationalism. Diderot's scientific works had a significant impact on subsequent philosophical and scientific discussions in the French and German intellectual worlds. The work laid the groundwork for a more holistic understanding of the natural world and influenced the development of scientific methodologies. Diderot's ideas resonated with other philosophers and intellectuals of the Enlightenment period, who recognized the importance of embracing a multidimensional perspective in scientific inquiry. Denis Diderot is a critical figure of the Enlightenment who receives little attention from modern day philosophers. Diderot lived in the shadow of Rousseau and Volatire, whom he knew and worked with.