Dental Pulp Stem Cells
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| Author | : Sibel Yildirim |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 89 |
| Release | : 2012-10-15 |
| Genre | : Science |
| ISBN | : 146145686X |
Stem cell technology is moving forward at a tremendous rate. Recent discoveries have surprised even the most expert researchers. While every piece of new data broadens the current knowledge and contributes to this moving forward, the new data also serve as paradigm shifters of fundamental knowledge of cell biology. While the question ‘What is a Stem Cell’ may now seem to basic to even discuss, there are still some discrepancies, however, between groups in terms of their functional roles. Teeth develop from the ectoderm of the first branchial arch and the ectomesenchyme of the neural crest. Deciduous teeth start to form between the sixth and eighth weeks, and permanent teeth begin to form in the twentieth weeks. Several studies have demonstrated that the pulp from both adult teeth and deciduous teeth contains dental pulp stem cells. Several factors have made them very attractive as a model system for many researchers; they are multipotent, ethically and non-controversially available in large numbers, immuno-compatible, developmentally primitive, easy to isolate and have high expansion potential in vitro. However, many controversies still exist in the field. There are several unanswered questions in the biology of dental pulp and odontoblasts. This new volume in the SpringerBriefs in Stem Cells series presents an evaluation of stem cells from human dental pulp as a reliable stem cell source for cell-based therapy to stimulate tissue regeneration.
| Author | : Barbara Zavan |
| Publisher | : Humana Press |
| Total Pages | : 288 |
| Release | : 2016-07-25 |
| Genre | : Science |
| ISBN | : 3319332996 |
This book focuses on the basic aspects of dental stem cells (DSCs) as well as their clinical applications in tissue engineering and regenerative medicine. It opens with a discussion of classification, protocols, and properties of DSCs and proceeds to explore DSCs within the contexts of cryopreservation; epigenetics; pulp, periodontal, tooth, bone, and corneal stroma regeneration; neuronal properties, mesenchymal stem cells and biomaterials; and as sources of hepatocytes for liver disease treatment. The fifteen expertly authored chapters comprehensively examine possible applications of DSCs and provide invaluable insights into mechanisms of growth and differentiation. Dental Stem Cells: Regenerative Potential draws from a wealth of international perspectives and is an essential addition to the developing literature on dental stem cells. This installment of Springer’s Stem Cell Biology and Regenerative Medicine series is indispensable for biomedical researchers interested in bioengineering, dentistry, tissue engineering, regenerative medicine, cell biology and oncology.
| Author | : Michel Goldberg |
| Publisher | : Springer |
| Total Pages | : 281 |
| Release | : 2014-07-30 |
| Genre | : Medical |
| ISBN | : 3642551602 |
This book provides a detailed update on our knowledge of dental pulp and regenerative approaches to therapy. It is divided into three parts. The pulp components are first described, covering pulp cells, extracellular matrix, vascularization and innervation as well as pulp development and aging. The second part is devoted to pulp pathology and includes descriptions of the differences between reactionary and reparative dentin, the genetic alterations leading to dentinogenesis imperfecta and dentin dysplasia, the pulp reaction to dental materials, adverse impacts of bisphenol A and the effects of fluorosis, dioxin and other toxic agents. The final part of the book focuses on pulp repair and regeneration. It includes descriptions of various in vitro and in vivo (animal) experimental approaches, definition of the pulp stem cells with special focus on the stem cell niches, discussion of the regeneration of a living pulp and information on new strategies that induce pulp mineralization.
| Author | : Dimitrios Tziafas |
| Publisher | : |
| Total Pages | : 108 |
| Release | : 1997 |
| Genre | : Dental pulp |
| ISBN | : |
| Author | : Mona Marei |
| Publisher | : Springer Nature |
| Total Pages | : 164 |
| Release | : 2022-06-01 |
| Genre | : Science |
| ISBN | : 3031025814 |
Dental caries, periodontitis, tooth loss, and bone resorption are considered prevalent health problems that have direct affect on the quality of life. While, advances in stem cell biology and biotechnology have sparked hope for devastating maladies, such as diabetes, cardiovascular diseases, etc., it also provides a strategy of regenerative therapy for dental tissues. From the prospective of tissue engineering, it is of utmost importance to understand and emulate the complex cell interactions that make up a tissue or organ. Unlike other tissues in the body, dental tissues are unique in their development, function, and even in their maintenance throughout life. The harmonized stimulations of biology and mechanical regulators to promote cellular activities have matured our understanding of the value of regenerative therapy of dental tissue versus the reparative treatment. In this book, we review the current knowledge available to regenerate alveolar bone, periodontal structure, and pulp/dentin complex. The book provides researchers with detailed information about development and functional characteristics of the dental unit with detailed protocols covering a comprehensive range of various approaches to engineer dental tissues: to use isolated cells or cell substitutes as cellular replacement, to use acellular biomaterials capable of inducing tissue regeneration, and/or to use a combination of cells, biomaterial and growth factors. We are well aware, with the concept changes in the field toward in-vitro biomimetics of in-vivo tissue development. The theoretical frame work integrating these concepts of developmental biology and developmental engineering is yet to be emphasized and implemented. Until this happens, we consider this book of regenerative dentistry as a call for scientists to achieve, researchers to innovate, practitioners to apply, and students to learn the art and science of regenerative therapy in dentistry. Table of Contents: Introduction to Regenerative Dentistry / Tissue Engineering Alveolar Bone / Tissue Engineering of the Periodontal Tissues / Dynamics for Pulp-Dentin Tissue Engineering in Operative Dentistry
| Author | : B.K.B. Berkovitz |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 868 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 3642834965 |
The editors and the publisher are pleased to present another volume in this series of monographs. The topic of teeth was last reviewed within the framework of this Handbook more than fifty years ago, in 1936, by Josef Lehner and HanDs Plenk of Vienna, who wrote a comprehensive treatise on the subject in volume V 3. / The introduction of new methods (e.g., transmission and scan ning electron microscopy, histochemistry, radioautography, element analysis) and progress in dental research have made an update necessary. In present times, characterized by scientific specialization and very rapid progress, it is virtually impossible to find a single individual prepared to review a field of research as large as that of teeth. Consequently. several authors were asked to contribute to the present volume. Originally. the intention was to cover the field in one volume. When it became clear that the material had become too extensive for a single volume, and when some authors were forced by external factors to withdraw from the project, it was decided to publish two volumes. In 1986, the volume Periodontium, written by Hubert E. Schroeder of Zurich. appeared in this series (volume VIS, 418 pages).
| Author | : Imad About |
| Publisher | : Springer Nature |
| Total Pages | : 233 |
| Release | : 2021-10-20 |
| Genre | : Medical |
| ISBN | : 3030809323 |
This book is a comprehensive guide to BiodentineTM, an innovative biocompatible and bioactive material based on pure tricalcium silicate that can permanently replace dentin and can also serve as a temporary enamel substitute. Although BiodentineTM has been widely used across the world for the past decade, this is the first book to be devoted to its properties, interactions with the soft and hard tissues, and its multiple clinical applications. The coverage encompasses applications in primary and permanent teeth, in specialties as diverse as restorative dentistry, endodontics, paediatric dentistry, dental traumatology, and prosthetic dentistry. BiodentineTM application both in vital pulp therapy and endodontic procedures is illustrated and clinical step by step protocols are provided. The book provides a detailed update on BiodentineTM use to preserve the pulp vitality in direct/indirect pulp capping, pulpotomy and irreversible pulpitis treatment. It also details BiodentineTM use for non-vital teeth treatment in indications such as root/furcation perforation repair, apexification as well as in regenerative endodontic procedures. BiodentineTM: Properties and Clinical Applications will be a rich source of guidance and information for all dentists as well as dental students and academics.
| Author | : Rachel J. Waddington |
| Publisher | : John Wiley & Sons |
| Total Pages | : 418 |
| Release | : 2016-11-18 |
| Genre | : Medical |
| ISBN | : 1118741072 |
Tissue Engineering and Regeneration in Dentistry: Current Strategies presents a thorough update on the current advances, methods and understanding in tissue engineering in dentistry. It offers invaluable tools, case studies, and methodologies for undertaking research, including important biological and practical considerations to facilitate successful migration of research from the bench to the clinic. Offers detailed coverage of the basic underlying principles and scientific evidence, and includes protocols to highlight practical applications Written by an internationally renowned team of expert contributors A must-have read for researchers and specialist clinicians in tissue engineering, oral biology, dental materials science, periodontology and oral surgery
| Author | : Petros Papagerakis |
| Publisher | : Humana Press |
| Total Pages | : 565 |
| Release | : 2019-04-22 |
| Genre | : Science |
| ISBN | : 9781493990115 |
This volume provides methods and approaches to study genetic and environmental regulatory controls on odontogenesis. Chapters guide readers through protocols for isolation and characterization of both epithelial and mesenchymal dental cells, methods on isolation, phenotypic characterization, expansion, differentiation, immunofluorescence, in situ hybridization, immunohistochemistry, imaging protocols, rodent dental fluorosis model, 3D assessment of crown size, dental diseases models, next generation sequencing, genetic and epigenetic studies, genome-wide association studies as well as clinical protocols for measurement of early childhood caries and saliva, and supragingival fluids and biofilm collection and subsequent analyses. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Odontogenesis: Methods and Protocols aims to guide researchers towards elucidating the secrets and mysteries of a fascinating and unique organ, the tooth.
| Author | : Klaus W. Neuhaus |
| Publisher | : John Wiley & Sons |
| Total Pages | : 314 |
| Release | : 2019-09-10 |
| Genre | : Medical |
| ISBN | : 111937264X |
A unique, multidisciplinary manual for the treatment of pediatric dental emergencies for general practitioners and non-pediatric specialists Management of Dental Emergencies in Children and Adolescents presents the diagnostic skills, treatment options, and management strategies necessary to provide effective and appropriate dental care for children and adolescents. This authoritative manual helps dental practitioners manage potentially stressful situations with children and adolescents while improving their competence in a wide range of urgent pediatric situations. An emphasis on managing the therapeutic demands of both younger patients and their parents enables readers to have greater confidence in handling demanding emergency situations in daily practice. An expert team of contributors explain how to manage tooth substance loss, endodontic problems in deciduous teeth, the long‐term consequences of early tooth loss, the dental issues related to oral health, and more. Guiding practitioners through the unique challenges of pediatric dental emergencies, this book: Explains the differences in treating and managing dental emergencies in children compared to adults Covers all types of pediatric dental emergencies including open pulp in permanent and deciduous teeth, missing teeth, and non-infective dental conditions Offers clinical vignettes and photographs to highlight clinical relevance Includes chapters by experts in multiple disciplines such as endodontics, restorative dentistry, pediatric dentistry, prosthodontics, and orthodontics The first textbook to focus exclusively on young patients in need of acute dental care, Management of Dental Emergencies in Children and Adolescents is a much-needed resource for general and specialist dentists as well as trainee and specialist pediatric dentists.
