The pursuit of development has increasingly prioritized sustainability. Sustainable approaches to development and adopting people’s well-being as a main goal have substantial implications for the competitiveness of territories. When viewed through a nature lens, sustainability maintains a close connection with circular economy. If sustainability is the paradigm to which the world needs to commit, businesses, policy makers and people have to deal with the difficulties and uncertainties arising from those requirements and other severe phenomena, like international armed conflicts and pandemic crises. By using case studies, this book addresses territorial bottlenecks and grapples with social and developmental challenges. The book intends to function as a practical guide for policymakers and practitioners, providing them with the knowledge necessary to adopt and implement sustainable development strategies. It advocates the implementation of socially inclusive policies and the adoption of innovative governance models able to safeguard democratic principles while enhancing the efficacy of decision-making processes.