Crosstalk Skin Cells And Immune Cells In Inflammatory Skin Diseases
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| Author | : Jeong Eun Kim |
| Publisher | : Frontiers Media SA |
| Total Pages | : 196 |
| Release | : 2024-09-11 |
| Genre | : Medical |
| ISBN | : 2832552986 |
The skin is the human body's largest organ consisting of two layers: epidermis and dermis, and appendages: hair, and sweat glands. The skin not only wraps the body but also protects it from external stimuli and infection, perceives sensations such as pain and itch, and coordinates with various circulating immune cells for immune response/regulation. Recent studies have shown that inflammatory skin diseases, including psoriasis and atopic dermatitis, harbor systemic inflammation/immune abnormalities such as strong Th activation and expansion of specific immune cell subsets. Novel biologics and small molecule inhibitors targeting specific biomarkers and immune signals are much more effective and safer than conventional systemic therapies for these skin diseases.
| Author | : Gerold Schuler |
| Publisher | : CRC Press |
| Total Pages | : 336 |
| Release | : 1990-12-26 |
| Genre | : Medical |
| ISBN | : 9780849356469 |
Epidermal Langerhans Cells focuses on epidermal Langerhans cells (LCs) and the important role they play in the induction of contact hypersensitivity and graft rejection. This in-depth work discusses how these antigen-presenting cells are modulated by various physicochemical agents (such as UV light) and how they can be infected by the AIDS virus. It also reveals that cytokines mediate their development into potent T cell-stimulatory dendritic cells. This comprehensive review covers important experimental details and methods, and fascinating information on LCs. It also provides an overview of the immune system as it relates to the skin in health and disease. This up-to-date publication is an indispensable resource for all investigative and clinical dermatologists, as well as immunologists interested in antigen-presenting cells.
| Author | : E. Carstens |
| Publisher | : CRC Press |
| Total Pages | : 482 |
| Release | : 2014-02-25 |
| Genre | : Science |
| ISBN | : 1466505435 |
Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.
| Author | : Alf Hamann |
| Publisher | : John Wiley & Sons |
| Total Pages | : 557 |
| Release | : 2006-05-12 |
| Genre | : Medical |
| ISBN | : 3527607013 |
Written by known specialists in the field, this is a comprehensive and timely overview of a central and expanding topic. Simultaneously an introduction and a description of the latest concepts, findings and methods, the handbook provides basic knowledge on technical issues required for those intending to research in the field. It covers the functional role of involved molecules and the cellular mechanisms, and addresses selected examples for their possible application in therapy -- bridging the gap between trafficking mechanisms and novel therapeutic strategies. In addition, it includes selection of proven and timesaving methods for studying cell trafficking in vitro and in vivo. The accompanying CD-ROM makes leukocyte migration videos available to a broad audience for the first time.
| Author | : Nava Dayan |
| Publisher | : John Wiley & Sons |
| Total Pages | : 432 |
| Release | : 2020-09-01 |
| Genre | : Medical |
| ISBN | : 1119592232 |
The book provides a comprehensive detailed summary of current status on skin microbiome research in health and disease as well as key regulatory and legal aspects. In the past decade, interest and technology have greatly advanced to unravel the nature and effect of skin microbiome on our health. Diseases such as atopic dermatitis and acne are at the forefront of this research, but also other conditions such as skin cancer are under investigation. In addition, mapping of the skin microbiome has gone from basic to more detailed with attempts to correlate it to various ages, ethnicities and genders. In parallel to mapping it, a great deal of research is dedicated to understanding its functionality and communication (and hence effect) on human cells. The Skin Microbiome Handbook is a summary of current status of knowledge, research tools and approaches in skin microbiome, in health and disease. It contains the following categories: healthy skin microbiome and oral-skin interaction; skin microbiome observational research; skin microbiome in disequilibrium and disease; skin's innate immunity; testing and study design; regulatory and legal aspects for skin microbiome related products. The 18 chapters of the book are written by carefully selected leaders in the academia and industry exhibiting extensive experience and understanding in the areas of interest.
| Author | : Manuela E. Gomes |
| Publisher | : Academic Press |
| Total Pages | : 471 |
| Release | : 2015-08-08 |
| Genre | : Science |
| ISBN | : 0128016000 |
Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes is the first book to highlight the multi-disciplinary nature of this specialized field and the importance of collaboration between medical and engineering laboratories in the development of tissue-oriented products for tissue engineering and regenerative medicine (TERM) strategies. Beginning with a foundation in developmental biology, the book explores physiology, pathology, and surgical reconstruction, providing guidance on biological approaches that enhances tendon regeneration practices. Contributions from scientists, clinicians, and engineers who are the leading figures in their respective fields present recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field. - Provides an overview of tendon biology, disease, and tissue engineering approaches - Presents modern, alternative approaches to developing functional tissue solutions discussed - Includes valuable information for those interested in tissue engineering, tissue regeneration, tissue physiology, and regenerative medicine - Explores physiology, pathology, and surgical reconstruction, building a natural progression that enhances tendon regeneration practices - Covers recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field
| Author | : Kasia Kozlowska |
| Publisher | : Springer Nature |
| Total Pages | : 397 |
| Release | : 2020-09-30 |
| Genre | : Psychology |
| ISBN | : 303046184X |
This open access book sets out the stress-system model for functional somatic symptoms in children and adolescents. The book begins by exploring the initial encounter between the paediatrician, child, and family, moves through the assessment process, including the formulation and the treatment contract, and then describes the various forms of treatment that are designed to settle the child’s dysregulated stress system. This approach both provides a new understanding of how such symptoms emerge – typically, through a history of recurrent or chronic stress, either physical or psychological – and points the way to effective assessment, management, and treatment that put the child (and family) back on the road to health and well-being.
| Author | : Gwendolyn Barcel´o-Coblijn |
| Publisher | : MDPI |
| Total Pages | : 206 |
| Release | : 2019-11-06 |
| Genre | : Medical |
| ISBN | : 3039216465 |
[Increasing evidence suggests that microbiota and especially the gut microbiota (the microbes inhabiting the gut including bacteria, archaea, viruses, and fungi) plays a key role in human physiology and pathology. Recent findings indicate how dysbiosis—an imbalance in the composition and organization of microbial populations—could severely impact the development of different medical conditions (from metabolic to mood disorders), providing new insights into the comprehension of diverse diseases, such as IBD, obesity, asthma, autism, stroke, diabetes, and cancer. Given that microbial cells in the gut outnumber host cells, microbiota influences human physiology both functionally and structurally. Microbial metabolites bridge various—even distant—areas of the organism by way of the immune and hormone system. For instance, it is now clear that the mutual interaction between the gastrointestinal tract and the brain (gut–brain axis), often involves gut microbiota, indicating that the crosstalk between the organism and its microbial residents represents a fundamental aspect of both the establishment and maintenance of healthy conditions. Moreover, it is crucial to recognize that beyond the intestinal tract, microbiota populates other host organs and tissues (e.g., skin and oral mucosa). We have edited this eBook with the aim of publishing manuscripts focusing on the impact of microbiota in the development of different diseases and their associated treatments.]
| Author | : Jean-Marc Cavaillon |
| Publisher | : John Wiley & Sons |
| Total Pages | : 1818 |
| Release | : 2018-02-20 |
| Genre | : Medical |
| ISBN | : 3527338993 |
Dieses Fachbuch erläutert die molekularen Grundlagen von Entzündungen, spannt den Bogen zu Infektionskrankheiten und den Zusammenhang zwischen Entzündungen und chronischen Erkrankungen, behandelt abschließend den Heilungsprozess und zeigt Therapiemöglichkeiten.
| Author | : Todd Leff |
| Publisher | : John Wiley & Sons |
| Total Pages | : 530 |
| Release | : 2010-03-19 |
| Genre | : Science |
| ISBN | : 9783527629534 |
This timely and most comprehensive reference available on the topic covers all the different aspects vital in the fight against the global obesity epidemic. Following a look at adipose tissue development and morphology, the authors go on to examine its metabolic and endocrine functions and its role in disease. The final section deals with comparative and evolutionary aspects of the tissue. The result is an essential resource for cell and molecular biologists, physiologists, biochemists, pharmacologists, and those working in the pharmaceutical industry.
