Control of Peptide Conformation by Design, Synthesis and Conformational Analysis of Peptidomimetics of Prolyl-leucylglycinamide
| Author | : Paul W. Baures |
| Publisher | : |
| Total Pages | : 514 |
| Release | : 1995 |
| Genre | : Neurophysiology |
| ISBN | : |
Control Of Peptide Conformation By Design Synthesis And Conformational Analysis Of Peptidomimetics Of Prolyl Leucylglycinamide
Download Control Of Peptide Conformation By Design Synthesis And Conformational Analysis Of Peptidomimetics Of Prolyl Leucylglycinamide full books in PDF, epub, and Kindle. Read online free Control Of Peptide Conformation By Design Synthesis And Conformational Analysis Of Peptidomimetics Of Prolyl Leucylglycinamide ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Conformation in Biology and Drug Design
| Author | : Sidney Udenfriend |
| Publisher | : Elsevier |
| Total Pages | : 516 |
| Release | : 2014-05-10 |
| Genre | : Science |
| ISBN | : 1483218007 |
The Peptides: Analysis, Synthesis, Biology, Volume 7: Conformation in Biology and Drug Design focuses on the analysis of peptides, emphasizing the use of physical methods in peptide conformational analysis and the relationship of conformational properties of peptides to biological properties. This book consists of nine chapters. Chapter 1 provides a brief overview of the perspective on the application of physical methods to peptide conformational analysis. The use of circular dichroism (CD) spectroscopy to examine the conformational properties of peptides in solution is elaborated in Chapter 2, while the use of fluorescence spectroscopy to examine the special relationships of aromatic side-chain groups to one another is discussed in Chapter 3. In Chapter 4, the use of various theoretical methods to calculate the conformations of peptides is described. The methods used to stimulate peptide conformations and dynamics are outlined in Chapter 5. The last four chapters examine various aspects of the use of nuclear magnetic resonance (NMR) in peptide conformational analysis. This volume is suitable for biologists, specialists, and researchers interested in peptides and proteins.
Peptidomimetics in Organic and Medicinal Chemistry
| Author | : Antonio Guarna |
| Publisher | : John Wiley & Sons |
| Total Pages | : 334 |
| Release | : 2014-03-14 |
| Genre | : Science |
| ISBN | : 1118683145 |
A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.
Design, Synthesis and Analysis of Conformationally Restricted Peptidomimetics of L-prolyl-L-leucyl-glycinamide
| Author | : Margaret Claire Evans |
| Publisher | : |
| Total Pages | : 332 |
| Release | : 1999 |
| Genre | : Hypothalamic hormones |
| ISBN | : |
Design and Synthesis of Type-VI Β-turn Mimics of L-prolyl-L-xaa-L-prolinamide
| Author | : Ashish Pramod Vartak |
| Publisher | : |
| Total Pages | : 286 |
| Release | : 2006 |
| Genre | : Peptides |
| ISBN | : |
Conformation in Biology and Drug Design
| Author | : Victor J. Hruby |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 1985 |
| Genre | : Conformational analysis |
| ISBN | : 9780123042071 |
The Peptides
| Author | : Sidney Udenfriend |
| Publisher | : |
| Total Pages | : 495 |
| Release | : 1985-11-01 |
| Genre | : Science |
| ISBN | : 9780123042071 |
Fluorine-containing Amino Acids
| Author | : Valery P. Kukhar |
| Publisher | : John Wiley & Sons |
| Total Pages | : 432 |
| Release | : 1995-04-06 |
| Genre | : Science |
| ISBN | : |
In recent years, organo-fluorine chemistry has made a marked impact on the design and synthesis of a large variety of biologically active molecules, such as steroids, carbohydrates, amines, amino acids, peptides and other natural products. Naturally occurring amino acids play a pivotal role in living systems, and therefore synthetic fluorine-containing amino acids have been of significant interest to researchers working towards the understanding and modification of physiological processes. Fluorine-containing Amino Acids: is the first volume devoted to the synthesis and properties of fluorine-containing amino acids pays special attention to the preparation of enantiomerically pure acids (which are essential to the modern pharmaceutical industry) deals with a rapidly expanding field of research has been written by experienced researchers who are responsible for many developments in the field highlights the interdisciplinary nature of this topic Fluorine-containing Amino Acids is the only dedicated reference in this subject and will be essential for researchers in synthetic organic, peptide, natural product, and medicinal chemistry and biochemistry.
