This book introduces the applications of Industry 4.0 in machine tools through an overview of the latest available digital technologies. It focuses on digital twining, communication between industrial controls, motion, and input/output devices, along with sustainability in SMEs. Machine Tools: An Industry 4.0 Perspective focuses on the digital twining of machine tools, which improves the life of the machines and provides a method of operating a factory during times of complete lockdown resulting from various conditions. It presents an overview of the communication between industrial controls, motion, and input/output devices through standardized digital interfaces such as SERCOS and USB. The book goes on to discuss industrial cybersecurity systems applicable to discrete manufacturing, which includes cyberattacks and human errors, and address the security aspects related to software, hardware, and data. The book also explores the application of big data for different stages of production and illustrates the uses such as predictive maintenance, product quality, product life cycle management (PLM), and more. This book is an ideal reference for undergraduate, graduate, and postgraduate students of industrial, mechanical, and mechatronics engineering, along with professionals, and general readers.