Lipid Nanocarriers for Drug Targeting

Lipid Nanocarriers for Drug Targeting
Author: Alexandru Mihai Grumezescu
Publisher: William Andrew
Total Pages: 676
Release: 2018-04-16
Genre: Science
ISBN: 012813688X

Lipid Nanocarriers for Drug Targeting presents recent advances in the area of lipid nanocarriers. The book focuses on cationic lipid nanocarriers, solid lipid nanocarriers, liposomes, thermosensitive vesicles, and cubosomes, with applications in phototherapy, cosmetic and others. As the first book related to lipid nanocarriers and their direct implication in pharmaceutical nanotechnology, this important reference resource is ideal for biomaterials scientists and those working in the medical and pharmaceutical industries that want to learn more on how lipids can be used to create more effective drug delivery systems. - Highlights the most commonly used types of lipid nanocarriers and explains how they are applied in pharmacy - Shows how lipid nanocarriers are used in different types of treatment, including oral medicine, skin repair and cancer treatment - Assesses the pros and cons of using different lipid nanocarriers for different therapies

Colloids in Drug Delivery

Colloids in Drug Delivery
Author: Monzer Fanun
Publisher: CRC Press
Total Pages: 654
Release: 2016-04-19
Genre: Medical
ISBN: 1439818266

Colloidal drug delivery systems present a range of therapeutic benefits in the treatment of a number of challenging conditions, allowing researchers to cross barriers that have previously prevented efficient treatment while offering improved and more targeted absorption. Summarizing recent research in the field, Colloids in Drug Delivery assembles

Colloid and Interface Science in Pharmaceutical Research and Development

Colloid and Interface Science in Pharmaceutical Research and Development
Author: Hiroyuki Ohshima
Publisher: Elsevier
Total Pages: 533
Release: 2014-07-23
Genre: Technology & Engineering
ISBN: 0444626085

Colloid and Interface Science in Pharmaceutical Research and Development describes the role of colloid and surface chemistry in the pharmaceutical sciences. It gives a detailed account of colloid theory, and explains physicochemical properties of the colloidal-pharmaceutical systems, and the methods for their measurement. The book starts with fundamentals in Part I, covering fundamental aspects of colloid and interface sciences as applied to pharmaceutical sciences and thus should be suitable for teaching. Parts II and III treat applications and measurements, and they explains the application of these properties and their influence and use for the development of new drugs. - Provides a clear description of the fundamentals of colloid and interface science relevant to drug research and development - Explains the physicochemical/colloidal basis of pharmaceutical science - Lists modern experimental characterization techniques, provides analytical equations and explanations on analyzing the experimental data - Describes the most advanced techniques, AFM (Atomic Force Microscopy), SFA (Surface Force Apparatus) in detail

Smart Drug Delivery System

Smart Drug Delivery System
Author: Ali Demir Sezer
Publisher: BoD – Books on Demand
Total Pages: 400
Release: 2016-02-10
Genre: Medical
ISBN: 9535122479

This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different smart drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, diabetic, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

Nano-Biomaterials For Ophthalmic Drug Delivery

Nano-Biomaterials For Ophthalmic Drug Delivery
Author: Yashwant Pathak
Publisher: Springer
Total Pages: 631
Release: 2016-11-12
Genre: Medical
ISBN: 331929346X

This consolidated reference book addresses the various aspects of nano biomaterials used in ophthalmic drug delivery, including their characterization, interactions with ophthalmic system and applications in treatments of the ophthalmic diseases and disorders. In the last decade, a significant growth in polymer sciences, nanotechnology and biotechnology has resulted in the development of new nano- and bioengineered nano-bio-materials. These are extensively explored as drug delivery carriers as well as for implantable devices and scaffolds. At the interface between nanomaterials and biological systems, the organic and synthetic worlds merge into a new science concerned with the safe use of nanotechnology and nano material design for biological applications. For this field to evolve, there is a need to understand the dynamic forces and molecular components that shape these interactions. While it is impossible to describe with certainty all the bio physicochemical interactions at play at the interface, we are at a point where the pockets of assembled knowledge are providing a conceptual framework to guide this exploration, and review the impact on future product development. The book is intended as a valuable resource for academics and pharmaceutical scientists working in the field of polymers, polymers materials for drug delivery, drug delivery systems and ophthalmic drug delivery systems, in addition to medical and health care professionals in these areas.

Colloidal Carriers for Controlled Drug Delivery and Targeting

Colloidal Carriers for Controlled Drug Delivery and Targeting
Author: Muller
Publisher: CRC Press
Total Pages: 379
Release: 1991-04-15
Genre: Medical
ISBN: 9780849377143

Colloidal carriers (particles, emulsions) for intravenous administration are a promising approach to achieve controlled release and site-specific delivery of drugs. The success of the systems will depend on their ability to maintain in blood circulation (controlled release system) or to reach target cells (e.g., bone marrow, blood cells). It is well known that the surface properties of i.v. injected particles are important factors determining the organ distribution and fate in vivo. Controlled surface modification could therefore be used to direct the carriers to the desired tissues. This book deals with the physico-chemical characterization of colloidal drug delivery systems and the influence of these parameters upon in vitro cell uptake and in vivo tissue distribution. Within the book, several different methods and their effect on surface characterization are discussed, and the in vivo tissue distribution of nanoparticles different in size and surface properties (coatings with Poloxamer/Polaximine/ethoxylated nonylphenols) and the carrier properties are examined in detail. The book does not deal with single aspects, but offers a comprehensive treatment of the subject. As a result, the book contributes to a better understanding of the factors influencing the organ distribution of i.v. drug carriers and provides useful information for the rational design of new carriers. It succeeds in clearing the way for future developments and the optimization of carriers for controlled drug delivery.

Targeted Drug Delivery : Concepts and Design

Targeted Drug Delivery : Concepts and Design
Author: Padma V. Devarajan
Publisher: Springer
Total Pages: 788
Release: 2014-12-08
Genre: Medical
ISBN: 3319113550

This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active targeting strategies, and various advanced drug delivery tools such as functionalized lipidic, polymeric and inorganic nanocarriers. Together, the twenty-three chapters cover a wide range of topics in the field, including tumor and hepatic targeting, polymer-drug conjugates, nanoemulsion, physical and biophysical characteristics of nanoparticles, and in vivo imaging techniques, among others. The book also examines advanced characterization techniques, regulatory hurdles and toxicity-related issues that are key features for successful commercialization of targeted drug delivery system products. Targeted Drug Delivery is a comprehensive reference guide for drug delivery researchers, both beginners and those already working in the field.

Nanoparticulates as Drug Carriers

Nanoparticulates as Drug Carriers
Author: V. P. Torchilin
Publisher: Imperial College Press
Total Pages: 758
Release: 2006
Genre: Technology & Engineering
ISBN: 186094907X

Written by key experts in the field of nanomedicine, this book provides a broad introduction to the important field of nanomedicine and application of nanotechnology for drug delivery. It covers up-to-date information regarding various nanoparticulate drug delivery systems, describes the various opportunities for the application of nanoparticular drug carriers in different areas of clinical medicine, and analyzes already available information on their clinical applications. This book can be used as an advanced textbook by graduate students and young scientists and clinicians at the early stages of their career. It is also suitable for non-experts from related areas of chemistry, biochemistry, molecular biology, biomedical engineering, physiology, experimental and clinical medicine, and pharmaceutical sciences, who are interested in general problems of drug delivery and drug targeting, as well as in more specialized topics of using nanoparticulate-mediated drug delivery approaches in the individual areas of clinical medicine. Prof Torchilin is an expert in Nanomedicine and a recipient of numerous awards including the Lenin Prize in Science & Technology of the former USSR, membership in the European Academy of Sciences, and AAPS Research Achievement Award in Pharmaceutics and Drug Delivery. He served as an Associate Professor of Radiology at Harvard Medical School before joining Northeastern University as the Chairman of the Department of Pharmaceutical Sciences. Sample Chapter(s). Chapter 1: Introduction. Nanocarriers for Drug Delivery: Needs and Requirements (442 KB). Contents: Nanoparticle Flow: Implications for Drug Delivery (A T Florence); Polymer Micelles as Drug Carriers (E V Batrakova et al.); Lipoproteins as Pharmaceutical Carriers (S Liu et al.); Dendrimers as Nanoparticular Drug Carriers (S Svenson & D A Tomalia); Cells and Cell Ghosts as Drug Carriers (J M Lanao & M L Sayalero); Magnetic Nanoparticles as Drug Carriers (U O Hnfeli & M Chastellain); Liposomal Drug Carriers in Cancer Therapy (A A Gabizon); Delivery of Nanoparticles to the Cardiovascular System (B-A Khaw); Nanoparticles for Targeting Lymphatics (W Phillips); Nanoparticular Carriers for Ocular Drug Delivery (A Sanchez & M J Alonso); and other papers. Readership: Graduate students, academics in nanomedicine, clinicians, pharmacologists, pharmacists, bioengineers, researchers in biotechnology and diagnostic imaging."